公开(公告)号：EP2364155A4

公开(公告)日：2012-12-12

申请号：EP09826853

申请日：2009-11-13

申请人： EASTERN VIRGINIA MED SCHOOL ,  UNIV OLD DOMINION

发明人： HARGAVE BARBARA Y ,  BLACKMORE PETER F ,  BEEBE STEPHEN J ,  SCHOENBACH KARL H

IPC分类号： A61K35/14 ,  A61L15/40 ,  A61L26/00 ,  A61N1/32

CPC分类号： C12N13/00 ,  A61K35/19 ,  A61L15/40 ,  A61L26/0057 ,  A61N1/326

摘要： Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm.

摘要翻译： 方法采用nsPEF的形成活化的血小板凝胶和施加激活的凝胶伤口，寻求心肌梗死后心脏组织。 血小板由大约10千伏/厘米和350千伏/厘米之间大约10皮秒之间具有持续时间将至少一个nsPEF到1微秒和电场强度被激活。

公开(公告)号：EP2015671A4

公开(公告)日：2010-05-05

申请号：EP07756059

申请日：2007-04-25

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： DELAHANTY THOMAS C ,  LATTANZIO FRANK A

IPC分类号： A61B5/00 ,  A61D5/00 ,  A61F9/007 ,  A61M27/00 ,  B65D81/00

CPC分类号： A61M5/16804 ,  A61B3/16 ,  A61B5/076 ,  A61B5/4839 ,  A61B2560/045 ,  A61F9/00781 ,  A61M39/22 ,  A61M39/28

公开(公告)号：EP1487432A4

公开(公告)日：2008-06-25

申请号：EP03721455

申请日：2003-03-26

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： DONCEL GUSTAVO F

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K31/185 ,  A61K31/315 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61P15/18 ,  A61P31/04 ,  A61P31/12

CPC分类号： A61K31/185 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/006 ,  A61K31/315 ,  A61K2300/00

摘要： The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.

公开(公告)号：EP2482771A4

公开(公告)日：2015-06-24

申请号：EP10821397

申请日：2010-10-04

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： SAKHEL KHALED

IPC分类号： A61B17/42 ,  A61B17/00

CPC分类号： A61B17/12013 ,  A61B1/303 ,  A61B17/2833 ,  A61B17/4241 ,  A61B2017/00358 ,  A61B2017/2212 ,  A61B2017/2837 ,  A61B2017/4225

公开(公告)号：EP2606058A4

公开(公告)日：2014-01-15

申请号：EP11810386

申请日：2011-07-21

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： CUNNION KENJI ,  KRISHNA NEEL K

IPC分类号： C07K14/08 ,  A61K38/16

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/03 ,  A61K38/162 ,  A61K38/1725 ,  A61K45/06 ,  C07K14/005 ,  C07K14/08 ,  C12N2770/12022 ,  C12N2770/12033

摘要： The present invention provides a pharmaceutical composition comprising a therapeutically effective amount of a synthetic peptide comprising the amino acid sequence of SEQ ID NO: 9 for use in reducing activity of the classical pathway of the complement system in a human subject in need thereof.

公开(公告)号：EP1986631A4

公开(公告)日：2010-10-27

申请号：EP07750513

申请日：2007-02-14

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： SCHELLENBERG KARL A ,  LATTANZIO FRANK A ,  SHAEFFER JAMES

IPC分类号： A61K31/21 ,  A61L27/54 ,  C07C327/00

CPC分类号： C07C327/28 ,  A61K31/16

公开(公告)号：EP2020850A4

公开(公告)日：2010-10-13

申请号：EP07794433

申请日：2007-05-01

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： WILLIAMS PATRICIA B ,  MARTIN BILLY R ,  LATTANZIO FRANK A ,  SAMUDRE SANDEEP ,  RAZDAN RAJ K

IPC分类号： A01N43/02 ,  A01N43/00

CPC分类号： A61K9/0048 ,  C07D231/12 ,  C07D233/61 ,  C07D249/08 ,  C07D295/145 ,  C07D311/80 ,  C07D405/06

公开(公告)号：EP1994408A4

公开(公告)日：2009-05-06

申请号：EP07762820

申请日：2007-01-29

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： OEHNINGER SERGIO C ,  SEMMES O JOHN ,  CAZARES LISA H ,  BOCCA SILVINA

IPC分类号： G01N33/53 ,  C12N15/00 ,  G01N33/537 ,  G01N33/543

CPC分类号： G01N33/6851 ,  G01N33/5088 ,  G01N33/689

摘要： The present invention discloses biomarkers and biomarker combinations that have prognostic value as predictors of the developmental potential of individual IVF-derived human embryos. In particular, the biomarkers of this invention are useful to classify an embryo with implantation competence after uterine transfer or implantation incompetence. In addition, the biomarkers can be detected by non-invasive methods that do not harm the developing embryo. Also disclosed are kits for the prediction of developmental potential that detect the biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of developmental potential.

公开(公告)号：EP1735620A4

公开(公告)日：2008-04-09

申请号：EP05731474

申请日：2005-03-30

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： SEMMES OLIVER JOHN ,  CAZARES LISA H ,  ROM WILLIAM

IPC分类号： G01N33/544 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68

CPC分类号： G01N33/6851 ,  G01N33/57423 ,  G01N2800/52

摘要： Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed.

公开(公告)号：EP1434790A4

公开(公告)日：2004-11-24

申请号：EP02757677

申请日：2002-09-11

申请人： EASTERN VIRGINIA MED SCHOOL

发明人： BUESCHER E STEPHEN

IPC分类号： A61K35/20 ,  A61P3/14 ,  A61P29/00 ,  C07G99/00 ,  C07K14/47 ,  C07K1/14 ,  C07K1/34

CPC分类号： C07K14/47

摘要： A purified factor isolated from human milk is provided. The factor is capable of inhibiting calcium-influx activity in polymorphonuclear leukocytes. A method for purification of the factor is also provided.