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公开(公告)号：EP3301090B1
公开(公告)日：2020-06-24
申请号：EP17151804.6
申请日：2017-01-17
发明人： Bae, Jae-Sung , Jin, Hee Kyung , Park, Min Hee
IPC分类号： C07D249/04 , A61K31/4192 , A61P25/24 , A61P25/28
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32.发明公开
公开(公告)号：EP3567048A1
公开(公告)日：2019-11-13
申请号：EP18736762.8
申请日：2018-01-04
申请人： Kyungpook National University Industry-Academic Cooperation Foundation , Korea Institute of Science and Technology
发明人： KIM, So Youn , SEO, Jun Young , KIM, In San
摘要： The present invention relates to: a fusion peptide comprising a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide; and a use thereof and, more specifically, to: a fusion peptide in which a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide are sequentially linked; a composition for preventing or treating thrombotic disorders, containing the same as an active ingredient; a method for treating thrombotic disorders; and a therapeutic use. According to the present invention, CLT-sFt-µPn DCNC as a novel plasmin-based thrombolytic nanocage has: an effect of targeting a site at which thrombus is present; a low sensitivity to inhibitors present in the circulatory system; pharmacological activity strongly destroying both arterial and venous thrombi; and no side effects of bleeding, and thus can be very useful in developing an agent for preventing or treating thrombotic disorders.
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33.发明公开
公开(公告)号：EP3546592A1
公开(公告)日：2019-10-02
申请号：EP17874580.8
申请日：2017-10-20
申请人： Kyungpook National University Industry-Academic Cooperation Foundation , IUCF-HYU (Industry-University Cooperation Foundation Hanyang University) , Samsung Life Public Welfare Foundation
发明人： BAE, Jae-Sung , JIN, Hee Kyung , LEE, Ju Youn , KIM, Seung Hyun , KI, Chang-Seok
摘要： The present invention relates to a amyotrophic lateral sclerosis (ALS) diagnostic composition using acid sphingomyelinase (ASM), and a method for detecting diagnostic markers and, more specifically, to a method and a composition for detecting markers for ALS, the method comprising the steps of: (a) providing a sample of a subject; (b) measuring the ASM expression level or the enzyme activation level in the sample; (c) determining that a subject, of which the ASM expression level or the enzyme activation level is increased compared to that of a normal person, has ALS. According to the investigation of the present inventors, the activity of ASM, among lipids and enzymes related to the sphingolipid metabolism, is specifically increased in a sample of an ALS patient compared to that of a normal person. ASM can be used as a marker for diagnosing ALS, thereby enabling the development of a novel and effective diagnostic reagent.
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公开(公告)号：EP3528205A1
公开(公告)日：2019-08-21
申请号：EP17859967.6
申请日：2017-10-13
发明人： SEO, Su Young
摘要： Provided is a method for setting an edge blur according to a brightness value including a first step for providing a plurality of target sheets on each of which a reference pattern for detecting a reference line and a grid pattern for detecting an edge position are provided, and in which changes in brightness values included in the grid patterns are different from each other, a second step for capturing images of the target sheets to obtain target sheet images, a third step for analyzing a reference pattern for each corresponding target sheet to estimate the reference line, and analyzing the grid pattern to extract an edge profile provided in the grid pattern, a fourth step for calculating a gradient of a brightness difference between adjacent pixels on the basis of the edge profile, and acquiring a background edge blur parameter and a foreground edge blur parameter on the basis of the gradient according to brightness contrast present in the image, and a fifth step for generating background edge blur prediction information and foreground edge blur prediction information for each pixel value, which respectively correspond to brightness values on a basis of distributions of the background edge blur parameter and the foreground edge blur parameter.
According to the present invention, a resolution pattern of a camera is accurately understood according to a contrast by predicting two edge parameters according to a brightness value, and a more accurate edge position having sub-pixel level precision can be determined through an edge blur having the predicted edge parameters, and thus, there is an effect of accurately and swiftly recognizing the edge position in camera resolution analysis, geographic information construction, autonomous mobile robot, or the like.-
公开(公告)号：EP3151196B1
公开(公告)日：2019-08-14
申请号：EP15800560.3
申请日：2015-05-29
申请人： Koh Young Technology Inc. , Kyungpook National University Industry-Academic Cooperation Foundation
发明人： LEE, Hyun Ki , CHAE, You Seong , KIM, Min Young
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36.发明授权
公开(公告)号：EP3151195B1
公开(公告)日：2019-08-14
申请号：EP15799209.0
申请日：2015-05-29
申请人： Koh Young Technology Inc. , Kyungpook National University Industry-Academic Cooperation Foundation
发明人： LEE, Hyun Ki , CHAE, You Seong , KIM, Min Young
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公开(公告)号：EP2815712B1
公开(公告)日：2019-06-19
申请号：EP13749314.4
申请日：2013-02-06
发明人： PARK, Jae Chan , SUK, Kyoung Ho , HAN, Hyung Soo , RHEE, Dong Ick
IPC分类号： A61F7/12
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公开(公告)号：EP3086248B1
公开(公告)日：2019-04-10
申请号：EP16157693.9
申请日：2016-02-26
发明人： KIM, Ji Sik , SOHN, Kee Sun , LEE, Jin Woong
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公开(公告)号：EP3345929A1
公开(公告)日：2018-07-11
申请号：EP16842349.9
申请日：2016-09-02
申请人： Kyungpook National University Industry-Academic Cooperation Foundation , Korea Institute of Science and Technology
发明人： BAE, Jong-Sup , KIM, In-San , LEE, Won Hwa , SEO, Jun Young , KIM, So Youn
摘要： The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.
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40.发明公开SCINTILLATOR, PREPARING METHOD THEREOF, AND APPLICATION THEREOF 审中-公开SZINTILLATOR，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP3157016A1
公开(公告)日：2017-04-19
申请号：EP14891990.5
申请日：2014-09-02
发明人： KIM, Hong Joo , PARK, Hwanbae , KIM, Sunghwan , ROOH, Gul
CPC分类号： C09K11/7773 , C09K11/62 , G01T1/20 , G01T1/2023 , G01T7/00 , G21K4/00
摘要： The present invention relates to a scintillator, method for manufacturing the same and applications of scintillator. The scintillator has a chemical formula of Tl 2 ABC 6 :yCe, wherein A includes at least one alkali element; B includes at least one trivalent element; C includes at least one halogen element; and y is greater than 0 and equal to or smaller than 1.
摘要翻译： 本发明涉及一种闪烁体，其制造方法和闪烁体的应用。 闪烁体具有化学式为Tl 2 ABC 6：yCe，其中A包含至少一个碱元素; B包括至少一个三价元素; C包括至少一个卤素元素; y大于0且等于或小于1。
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