利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

58 条记录 (耗时 0.021 秒)

    COMBINATION THERAPY FOR ISCHEMIA
    31.
    发明授权
    COMBINATION THERAPY FOR ISCHEMIA 有权

    公开(公告)号：EP2723363B1

    公开(公告)日：2018-08-29

    申请号：EP12802409.8

    申请日：2012-06-23

    申请人： NoNO Inc.

    发明人： TYMIANSKI, Michael

    IPC分类号： A61K38/17 ,  A61K38/49 ,  A61P25/00 ,  A61P9/10 ,  A61M31/00

    CPC分类号： A61K38/10 ,  A61K38/1787 ,  A61K38/49 ,  A61K2300/00

    摘要： The invention provides a combination treatment for ischemia conditions in or otherwise affecting the CNS, such as stroke. The treatment invoices administration of a PSD-95 inhibitor and performing reperfusion therapy (e.g. by administration of tPA). Administration a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of the reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy with time after onset of ischemia thus extending the window in which reperfusion therapy can be administered.

    CHLORIDE SALT OF TAT-NR2B9C
    32.
    发明公开
    CHLORIDE SALT OF TAT-NR2B9C 审中-公开
    CHLORIDSALZ VON TAT-NR2B9C

    公开(公告)号：EP3149048A1

    公开(公告)日：2017-04-05

    申请号：EP15799583.8

    申请日：2015-05-28

    申请人： Nono Inc.

    发明人： GARMAN, Jonathan David

    IPC分类号： C07K19/00 ,  A61K38/16 ,  A61K9/19 ,  A61P9/10 ,  C07K14/16 ,  C07K14/705 ,  C07K7/06 ,  C07K7/08

    CPC分类号： A61K38/162 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K38/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C07K7/06 ,  C07K7/08 ,  C07K14/005 ,  C07K14/16 ,  C07K14/163 ,  C07K14/705 ,  C07K19/00 ,  C12N2740/16322

    摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c, as chloride salts. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. The chloride salt of TAT-NR2B9c shows improved stability compared with the acetate salt form of prior formulations. Formulations of the chloride salt of TAT-NR2B9c are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.

    摘要翻译： 本发明提供活性剂，特别是作为氯化物盐的TAT-NR2B9c的冻干制剂。 TAT-NR2B9c已经显示出治疗中风，动脉瘤，蛛网膜下腔出血以及其他神经或神经功能障碍的前景。 与先前制剂的乙酸盐形式相比，TAT-NR2B9c的氯化物盐显示出改进的稳定性。 TAT-NR2B9c的氯化物盐的配方在环境温度下是稳定的，因此有助于维护在救护车上的这种制剂的供应，以便在疾病或意外现场进行管理或者转运到医院。

    LYOPHILIZED FORMULATION OF TAT-NR2B9C
    33.
    发明公开
    LYOPHILIZED FORMULATION OF TAT-NR2B9C 审中-公开
    TAT NR2B9C冻干制剂

    公开(公告)号：EP2925338A4

    公开(公告)日：2016-05-25

    申请号：EP13859059

    申请日：2013-11-25

    申请人： NONO INC

    发明人： GARMAN JONATHAN DAVID

    IPC分类号： A61K38/08 ,  A61K38/10

    CPC分类号： A61K38/10 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/177 ,  A61K47/183 ,  A61K47/26

    摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at room temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.