公开(公告)号：EP4317165A1

公开(公告)日：2024-02-07

申请号：EP22775737.4

申请日：2022-03-24

Applicant: OSAKA UNIVERSITY

Inventor： SHIRAKAMI, Yoshifumi ,  KANEDA, Kazuko ,  KADONAGA, Yuichiro ,  WATABE, Tadashi ,  TOYOSHIMA, Atsushi ,  FUKASE, Koichi ,  SHINOHARA, Atsushi ,  YAMANAKA, Toshio ,  KONDOH, Yutaka

IPC: C07F5/02 ,  A61P35/00 ,  C07B59/00 ,  C07C227/16 ,  C07C229/36 ,  A61K31/198

Abstract: The present invention provides a method for producing radiolabeled tyrosine derivatives with good purity and stability, by a safe method suitable for industrial production of pharmaceuticals.
The present invention relates to a method for producing Compound (5) and Radiolabeled Compound (6).

wherein each symbol is as defined in the description.

公开(公告)号：EP4310095A1

公开(公告)日：2024-01-24

申请号：EP22771444.1

申请日：2022-03-15

Applicant: OSAKA UNIVERSITY ,  KOTAI Biotechnologies, Inc.

Inventor： YAMASAKI, Sho ,  LU, Xiuyuan ,  HOSONO, Yuki ,  ISHIZUKA, Shigenari ,  YAMASHITA, Kazuo ,  SAX, Nicolas Claude Paul

IPC: C07K14/165 ,  A61K35/26 ,  A61K39/215 ,  A61P11/00 ,  A61P31/14 ,  C07K16/10 ,  C12N15/13 ,  C12N15/50

Abstract: Follicular helper T cells specific to SARS-CoV-2 virus are provided. The present disclosure is based on the finding of public TfhTCR specific to spike (S) protein common to various patients, and has identified for the first time a public TCR specific to the SARS-CoV-2 virus and its MHC and antigenic epitopes to promote efficient immune responses, particularly those of B cells that produce neutralizing antibodies. For example, the present disclosure provides a composition containing an epitope specific to SARS-CoV-2 virus for inducing a follicular T cell.

公开(公告)号：EP4303298A1

公开(公告)日：2024-01-10

申请号：EP21929220.8

申请日：2021-12-16

Applicant: Daicel Corporation ,  OSAKA UNIVERSITY

Inventor： SAKAGUCHI, Yuko ,  CHANG, Chin-Yang ,  MATSUBARA, Yayoi

IPC: C12N5/00 ,  C12M1/00 ,  C12N1/00

Abstract: An object of the present disclosure is at least to provide a cell fusion method having a high cell fusion rate. The object is solved by a cell fusion method including pressurizing, by a pressurization portion, a solution containing multiple cells of one or more types and at least one type of chemical cell fusion agent, the solution contained in a container portion.

公开(公告)号：EP4299766A2

公开(公告)日：2024-01-03

申请号：EP23187345.6

申请日：2017-09-26

Applicant: Osaka University

Inventor： KOBAYASHI, Takeshi ,  KANAI, Yuta

IPC: C12Q1/70

Abstract: Provided is a method for producing an artificial recombinant virus of the family Reoviridae, the method comprising the steps of:
(1) introducing a FAST protein expression vector and/or a capping enzyme expression vector into host cells;
(2) introducing a vector containing expression cassettes for individual RNA genome segments of a virus or introducing a set of single-stranded RNA transcripts from the expression cassettes into host cells; and
(3) culturing the host cells.
The method of the present invention allows more efficient production of an artificial recombinant virus of the family Reoviridae as compared with conventional methods and allows artificial recombinant rotavirus production without using a helper virus.

公开(公告)号：EP4295782A1

公开(公告)日：2023-12-27

申请号：EP21926715.0

申请日：2021-11-15

Applicant: Osaka University ,  Heartlab, Inc.

Inventor： MIYAGAWA, Shigeru ,  SAWA, Yoshiki ,  ASANOI, Hidetsugu ,  IKEGAWA, Sunao

IPC: A61B10/00 ,  A61B5/08 ,  A61B5/11 ,  A61B5/113

Abstract: The present invention relates to an evaluation device 4 for evaluating the severity of pneumonia in a target patient, comprising: an acquisition unit 42 for acquiring a respiratory waveform of the target patient; a calculation unit 43 for calculating a value of an index indicating instability of a respiratory cycle or a respiratory frequency from the respiratory waveform; and an evaluation unit 44 for evaluating the severity based on the calculated value.

公开(公告)号：EP4235825A3

公开(公告)日：2023-10-25

申请号：EP23175060.5

申请日：2018-02-28

Applicant: National University Corporation Tokai National Higher Education and Research System ,  OSAKA UNIVERSITY ,  Nichia Corporation

Inventor： TORIMOTO, Tsukasa ,  KAMEYAMA, Tatsuya ,  KISHI, Marino ,  MIYAMAE, Chie ,  KUWABATA, Susumu ,  UEMATSU, Taro ,  OYAMATSU, Daisuke ,  NIKI, Kenta

IPC: C09K11/62 ,  B82Y30/00 ,  B82Y40/00 ,  C01G15/00 ,  C09K11/08 ,  H01L33/50

Abstract: Core-shell semiconductor nanoparticles, comprising:
a core containing Ag, In, Ga, and S;
a shell containing a Group 13 element and a Group 16 element,
wherein the core-shell semiconductor nanoparticles emit light having an emission peak with a wavelength in a range of from 500 nm to less than 590 nm, and a half bandwidth of 70 nm or less upon irradiation of light.

公开(公告)号：EP4245781A1

公开(公告)日：2023-09-20

申请号：EP21891814.2

申请日：2021-11-08

Applicant: Daikin Industries, Ltd. ,  OSAKA UNIVERSITY

Inventor： AKUTA, Ryou ,  HIGASHI, Masahiro ,  KAWABE, Takuma ,  ASOH, Taka-Aki ,  UYAMA, Hiroshi

IPC: C08F220/10 ,  C08F224/00 ,  C09K3/18

Abstract: The present invention provides a vinyl copolymer which has liquid repellency and biodegradability by means of a copolymer which has a repeating unit that is derived from a hydrophobic monomer having an ethylenically unsaturated double bond and a hydrocarbon group having from 3 to 40 carbon atoms, and a repeating unit that is derived from a cyclic vinylidene monomer, which is a compound represented by formula (wherein X represents an aliphatic group having from 1 to 10 carbon atoms; and Z represents at least one atom or group that is selected from the group consisting of a hydrogen atom, a hydrocarbon group having from 1 to 6 carbon atoms, and halogen atoms).

公开(公告)号：EP4238985A1

公开(公告)日：2023-09-06

申请号：EP21885941.1

申请日：2021-10-15

Applicant: OSAKA UNIVERSITY ,  TOPPAN INC. ,  Kyoto Prefectural Public University Corporation

Inventor： MATSUSAKI Michiya ,  LOUIS Fiona ,  KITANO Shiro ,  SOWA Yoshihiro

IPC: C07K14/745 ,  C07K14/78 ,  C12N5/071 ,  C12N5/077 ,  C12N1/04

Abstract: The present invention relates to a method for freezing a cell structure including freezing a cell structure including fragmented extracellular matrix components, cells and fibrin and having a three-dimensional tissue structure.

公开(公告)号：EP4205762A1

公开(公告)日：2023-07-05

申请号：EP21875809.2

申请日：2021-09-30

Applicant: OSAKA UNIVERSITY ,  Takara Bio Inc. ,  AnGes, Inc.

Inventor： NAKAGAMI, Hironori ,  MORISHITA, Ryuichi ,  HAYASHI, Hiroki ,  AMAISHI, Yasunori ,  OKAMOTO, Sachiko ,  MINENO, Junichi ,  IKAI, Hisato ,  MICHIBATA, Junko ,  KOMATSUNO, Takao

IPC: A61K39/215 ,  A61K39/39 ,  A61P31/14 ,  C12N15/50 ,  C12N15/63 ,  C12N15/86 ,  A61K35/76 ,  A61K31/711

Abstract: Provided is DNA that: encodes a coronavirus (SARS CoV-2) spike protein or a fragment thereof; and has been optimized to partially or fully exhibit a codon included in a DNA sequence.

公开(公告)号：EP4201899A1

公开(公告)日：2023-06-28

申请号：EP22215605.1

申请日：2022-12-21

Applicant: OSAKA UNIVERSITY ,  GC Corporation

Inventor： IMAZATO, Satoshi ,  KITAGAWA, Haruaki ,  AKIYAMA, Ayaka ,  KONO, Tomoki ,  KATO, Katsuhito

IPC: C03C4/00 ,  C03C12/00 ,  C03C3/062 ,  C03C3/066 ,  C03C3/068 ,  C03C3/12 ,  C03C3/16 ,  C03C3/17

Abstract: A glass powder composite includes a first glass powder, and a second glass powder having a different solubility from that of the first glass powder depending on pH, wherein both the first glass powder and the second glass powder have ion sustained-release properties.