公开(公告)号：EP2170344A1

公开(公告)日：2010-04-07

申请号：EP08778016.9

申请日：2008-07-03

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557 ,  A61K45/06 ,  A61P29/00 ,  C07C405/00

CPC分类号： A61K31/485 ,  A61K31/5575 ,  A61K45/06 ,  A61K2300/00

摘要： Provided is a method for treating a condition or disease which is one of the indications for opioid use, which comprises administering a combination of: (a) a pharmaceutically effective amount of an opioid, and (b) a pharmaceutically effective amount of a prostaglandin (PG) compound represented by the formula (I): to a patient in need thereof.

公开(公告)号：EP2114411A2

公开(公告)日：2009-11-11

申请号：EP08721151.2

申请日：2008-02-26

申请人： Sucampo AG

发明人： UENO, Ryuji ,  KUNO, Sachiko ,  CUPPOLETTI, John

IPC分类号： A61K31/5575 ,  A61P25/00 ,  A61P21/00 ,  A61P9/04 ,  A61P27/02 ,  A61P13/12 ,  A61P11/00

CPC分类号： A61K31/5575

摘要： The present invention relates to a composition for protecting mitochondria from damage in a mammalian subject which comprises a specific prostaglandin compound. The present invention also relates to a pharmaceutical composition for treating mitochondrial dysfunction as well as a condition associated with mitochondrial dysfunction in a mammalian subject which comprises a prostaglandin compound.

公开(公告)号：EP1267883B1

公开(公告)日：2009-06-17

申请号：EP01917828.4

申请日：2001-04-05

申请人： Sucampo AG

发明人： UENO, Ryuji ,  SUEMATSU, Makoto

IPC分类号： A61K31/557 ,  A61K31/35 ,  A61K31/335 ,  A61P1/16 ,  A61P1/18

CPC分类号： A61K31/558 ,  A61K31/5575 ,  A61K31/5585

摘要： Disclosed is a bile secretion promoting composition comprising a 15-keto-prostaglandin compound as an active ingredient. The composition is useful for treatment of a subject having a condition or disease associated with bile secretion deficiency and also for treatment of a liver to be transplanted in a liver transplantation process.

公开(公告)号：EP1861169A2

公开(公告)日：2007-12-05

申请号：EP06730328.9

申请日：2006-03-22

申请人： Sucampo AG ,  NORTH CAROLINA STATE UNIVERSITY

发明人： UENO, Ryuji ,  KUNO, Sachiko ,  BLIKSLAGER, Anthony, T. ,  MOESER, Adam, J.

IPC分类号： A61P1/04 ,  A61P35/00 ,  A61K31/557 ,  C07C405/00

CPC分类号： C07C405/00 ,  A61K31/557

摘要： Provided is a method and composition for treating mucosal disorders using a specific prostaglandin compound. The prostaglandin compound induces a conformational change in the tight junction that results in recovery of mucosal barrier function. Accordingly, the prostaglandin compound used herein is useful for the treatment of mucosal disorders.

公开(公告)号：EP1853271A2

公开(公告)日：2007-11-14

申请号：EP06715488.0

申请日：2006-03-03

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61P9/02 ,  A61P9/10

CPC分类号： A61K31/5575 ,  A61K31/557

摘要： The present invention provides a method for treating peripheral vascular diseases in a mammalian subject, which comprises administering to the patient in need thereof an effective amount of 11-deoxy-prostaglandin compound.

公开(公告)号：EP1392318B1

公开(公告)日：2007-02-28

申请号：EP02720623.4

申请日：2002-04-26

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557 ,  A61P1/10

CPC分类号： A61K31/557 ,  A61K31/485 ,  A61K31/5575 ,  A61K2300/00

摘要： Provided is a composition for treatment of drug-induced constipation comprising a 15-keto-prostaglandin compound as an active ingredient. The composition of the present invention has a strong antagonistic action against drug-induced constipation without substantially losing the main effect of the drug.

公开(公告)号：EP1553953A1

公开(公告)日：2005-07-20

申请号：EP03758746.6

申请日：2003-10-22

申请人： Sucampo Ag (USA) Inc.

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K31/5377 ,  A61K47/26 ,  A61K9/00

CPC分类号： A61K31/5575 ,  A61K9/0048 ,  A61K31/5377 ,  A61K31/557 ,  A61K47/186 ,  A61K47/26 ,  Y10S514/903

摘要： Provided is an ophthalmic composition for treating ocular hypertension and glaucoma with reduced side effects such as keratoconjunctive disorders and macular edema. The composition comprises latanoprost as an active ingredient thereof and substantially no benzalkonium chloride. The composition of the invention especially useful for the treatment in a patient suffering from or is likely to suffer from keratoconjunctive disorders and/or macular edema.

公开(公告)号：EP1426361A1

公开(公告)日：2004-06-09

申请号：EP04005836.4

申请日：2000-10-13

申请人： Sucampo AG

发明人： Ueno, Ryuji ,  Habe, Tsuyoshi

IPC分类号： C07D221/04 ,  A61K31/352 ,  A61K47/12 ,  A61P11/08

CPC分类号： A61K9/4858 ,  A61K9/0048 ,  C07C69/738 ,  C07D311/94 ,  C07D333/78 ,  C07D335/04

摘要： Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.

摘要翻译： 公开了包含预期是药学活性的新型双环化合物和甘油酯的新型组合物。 通过将其溶解在甘油酯中可以显着提高双环化合物的稳定性。

公开(公告)号：EP1420793A1

公开(公告)日：2004-05-26

申请号：EP02760691.2

申请日：2002-08-22

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557

CPC分类号： A61K31/5575

摘要： Provided is a method for treating ocular hypertension and glaucoma, which comprises administrating an effective amount of 15-keto-prostaglandin compound having a ring structure at the end of the φ chain to the eyes of a mammalian subject in need of such treatment once a day. According to the method, single administration of the compound effectively lower the IOP of the subject throughout the day.

公开(公告)号：EP1390035A1

公开(公告)日：2004-02-25

申请号：EP02724768.3

申请日：2002-05-13

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61P27/06

CPC分类号： A61K31/5575 ,  A61K9/0048

摘要： A method for treating ocular hypertension and glaucoma, which comprises an administration of eye drops comprising a 15-keto-prostaglandin compound as an active ingredient to a subject in need of such treatment in a single administration volume of at least 20νmuL/eye is disclosed. According to the present method, the intraocular pressure reducing effect of the compound is surprisingly augmented.