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公开(公告)号：EP2812324A1
公开(公告)日：2014-12-17
申请号：EP13747266.8
申请日：2013-02-08
申请人： Sunovion Pharmaceuticals Inc. , Campbell, John Emmerson , Campbell, Una , Hanania, Taleen G. , Shao, Liming
IPC分类号： C07D405/04
CPC分类号： C07D409/04 , C07D405/04 , C07D409/14 , C07D491/048 , C07D495/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：EP2393357A4
公开(公告)日：2013-11-27
申请号：EP10739175
申请日：2010-02-05
发明人： SHAO LIMING , MA JIANGUO
CPC分类号： C07D207/06 , A61K31/40 , C07D207/08 , C07D207/12 , C07D405/04
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33.发明公开
公开(公告)号：EP2440563A1
公开(公告)日：2012-04-18
申请号：EP10724650.6
申请日：2010-06-09
IPC分类号： C07D491/10 , C07D491/20 , A61K31/438 , A61P3/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D491/10 , C07D491/20
摘要： Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.
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34.发明公开COMPOSITIONS COMPRISING TRANSNORSERTRALINE AND SEROTONIN RECEPTOR 1A AGONISTS/ ANTAGONISTS AND USES THEREOF 审中-公开组合物TRANSNORSERTRALIN-和血清素1A受体激动剂/拮抗剂及其用途
公开(公告)号：EP2429514A1
公开(公告)日：2012-03-21
申请号：EP10719204.9
申请日：2010-05-12
发明人： CAMPBELL, Una , DUNN, Judith
IPC分类号： A61K31/135 , A61K31/535 , A61K31/44 , A61K31/496 , A61K31/505 , A61P25/00
CPC分类号： A61K45/06 , A61K31/135 , A61K31/44 , A61K31/496 , A61K31/505 , A61K31/535 , A61K2300/00
摘要： Provided herein are methods of, and compositions for, treating, preventing and managing various neurological disorders. The methods comprise administering a transnorsertraline in combination with a serotonin receptor IA agonist, antagonist or modulator.
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35.发明公开
公开(公告)号：EP2396327A1
公开(公告)日：2011-12-21
申请号：EP10705454.6
申请日：2010-02-11
IPC分类号： C07D471/14 , C07D487/04 , A61K31/551 , A61P25/28
CPC分类号： C07D487/04 , C07D471/14
摘要： Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
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36.发明公开
公开(公告)号：EP3840754A2
公开(公告)日：2021-06-30
申请号：EP19851623.9
申请日：2019-08-23
发明人： BILBAULT, Thierry
IPC分类号： A61K31/473 , A61K31/485 , A61P15/10 , A61P25/16
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公开(公告)号：EP3735988A1
公开(公告)日：2020-11-11
申请号：EP20167201.1
申请日：2011-12-16
发明人： BRYSON, Nathan, John , GIOVINAZZO, Anthony, John , BARNHART, Scott, David , KOONS, Michael, Clinton
IPC分类号： A61K47/02 , A61K9/70 , A61K47/14 , A61K47/38 , A61K31/4045 , A61K31/485 , A61K31/473 , A61K31/381 , A61K31/428 , A61K31/4415 , A61K31/48 , A61K31/4985 , A61K31/506 , A61K45/06 , A61P25/16 , A61P43/00 , A61F13/00
摘要： The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
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公开(公告)号：EP3582815A1
公开(公告)日：2019-12-25
申请号：EP18712284.1
申请日：2018-02-16
发明人： HOPKINS, Seth , KOBLAN, Kenneth , LOEBEL, Antony , OGIRALA, Ajay
IPC分类号： A61K45/06 , A61K31/381 , A61K31/435 , A61K31/55 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , C07D277/60 , A61P25/18
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公开(公告)号：EP3577102A1
公开(公告)日：2019-12-11
申请号：EP18747673.4
申请日：2018-01-29
IPC分类号： C07C231/14 , C07C231/12 , C07C249/08
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公开(公告)号：EP3490607A1
公开(公告)日：2019-06-05
申请号：EP17835384.3
申请日：2017-07-28
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