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109 条记录 (耗时 0.034 秒)

    PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION
    32.
    发明公开
    PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION 有权
    含吡啶或嘧啶衍生物对抑制细胞因子的产生和分泌的药物组合物

    公开(公告)号：EP1171127A2

    公开(公告)日：2002-01-16

    申请号：EP00926142.1

    申请日：2000-04-20

    申请人： Targacept, Inc.

    发明人： BENCHERIF, Merouane

    IPC分类号： A61K31/435 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61P37/06 ,  A61P29/02

    CPC分类号： C07D213/38 ,  A61K31/4406 ,  Y02A50/411

    摘要： Pharmaceutical compositions incorporate compounds that affect cytokine production and/or secretion. Such compounds include aryl substituted olefinic amine compounds, pyridyloxylalkylamines and phenoxyalkylamines, and aryl substituted amine compounds, such as 3-aminophenyl amine compounds. Such pharmaceutical compositions can be used for treating a wide variety of conditions, diseases and disorders, and particularly those associated with dysfunction of cytokine production and/or secretion. Of particular interest are pharmaceutical compositions useful for preventing and treating conditions, diseases and disorders associated with undesirably high levels of cytokine production and/or secretion. Such pharmaceutical compositions are useful for treating the effects of inflammatory bowel disease, inflammation, arthritis, cachexia in neoplastics diseases or associated with AIDS, and autoimmune diseases.

    (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide
    37.
    发明公开
    (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide 审中-公开
    （2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩-2-甲酰胺

    公开(公告)号：EP2484363A1

    公开(公告)日：2012-08-08

    申请号：EP12164661.6

    申请日：2008-08-01

    申请人： Targacept, Inc. ,  Medical College of Georgia Research Institute, Inc

    发明人： Mazurov,, Anatoly A

    IPC分类号： A61K31/4545 ,  A61P25/00 ,  A61P25/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  A61K45/06 ,  C07D453/02

    CPC分类号： C07D453/02 ,  A61K31/439

    摘要： The present invention related to the α7-selective ligand (2S,3R)-N-(2-((3-pyridinyl)methyl)-l-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, substantially free of (2R,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof, (2S,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide or a pharmaceutical acceptable salt thereof and (2R,3S)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene -2-carboxamide or a pharmaceutical acceptable salt thereof.

    摘要翻译： 本发明涉及±7-选择性配体（2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩 - （2S，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩-2 - 甲酰胺或其药学上可接受的盐，基本上不含（2R，3R）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩 -2-甲酰胺或其药学上可接受的盐，（2S，3S）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩 - -2-甲酰胺或其药学上可接受的盐和（2R，3S）-N-（2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-5-甲基噻吩-2 甲酰胺或其药学上可接受的盐。

    Polymorph forms of (2S) - (4E) -N-methyl-5- (3-isopropoxypyridin) yl]-4-penten-2-amine for the treatment of central nervous system disorders
    39.
    发明公开
    Polymorph forms of (2S) - (4E) -N-methyl-5- (3-isopropoxypyridin) yl]-4-penten-2-amine for the treatment of central nervous system disorders 有权
    （4E）-N-甲基-5 - - [（3-（5-异丙氧基吡啶）基] -4-戊烯-2-胺对羟基苯甲酸酯用于中枢神经系统疾病的治疗中的（2S）多晶型形式

    公开(公告)号：EP2418201A1

    公开(公告)日：2012-02-15

    申请号：EP11167528.6

    申请日：2007-05-08

    申请人： Targacept, Inc.

    发明人： Munoz, Julio A. ,  Dull, Gary Maurice

    IPC分类号： C07D213/63 ,  A61K31/44 ,  A61P25/28

    CPC分类号： C07D213/65

    摘要： Polymorph forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine p-hydroxybenzoate, and methods for their preparation, pharmaceutical composition containing said polymorph(s) and use, are disclosed. The polymorphs can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.

    摘要翻译： （2S）的多晶型物形式的 - （4E）-N-甲基-5- [3-（5-异丙氧基吡啶）基] -4-戊烯-2-胺对羟基苯甲酸盐，和它们的制备方法，药物组合物，包含所述多晶型 （一个或多个）和使用，是游离缺失盘。 多晶型物可给药于患者易患或从病症和障碍，：例如中枢神经系统疾病的患者，以治疗和/或预防检查病症。