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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    31.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2347260A2

    公开(公告)日：2011-07-27

    申请号：EP09822670.7

    申请日：2009-10-21

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin-1, soluble Angiopoietin-1 receptor, C-X-C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin- 1, C-C motif chemokine 22, C-C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用检测选自以下的一种或多种标记物的测定法：可溶性CD44抗原，促血管生成素-1，可溶性促血管生成素-1受体，CXC趋化因子基序5，可溶内皮糖蛋白，可溶性肿瘤相关钙信号转导子 1，促红细胞生成素，可溶性Fractalkine，血红素加氧酶1，可溶性白细胞介素-1受体II型，可溶性白细胞介素-6受体亚单位-α，淋巴肿瘤素，淋巴毒素-α，溶基质素-1，CC基序趋化因子22，CC基序趋化因子5和血小板反应蛋白 -1作为肾损伤的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    32.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2324355A1

    公开(公告)日：2011-05-25

    申请号：EP09810695.8

    申请日：2009-08-28

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha- 1 -antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用检测选自以下的一种或多种标记物的测定法：可溶性p-选择素，蛋白质NOV同系物，可溶性表皮生长因子受体，netrin-4，触珠蛋白，热休克蛋白β-1， - 1-抗胰蛋白酶，白细胞弹性蛋白酶，可溶性肿瘤坏死因子受体超家族成员6，可溶性肿瘤坏死因子配体超家族成员6，可溶性细胞间粘附分子2，活性半胱天冬酶-3和可溶性血小板内皮细胞粘附分子作为诊断和预后生物标志物 肾脏损伤。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    33.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开

    公开(公告)号：EP3974836A1

    公开(公告)日：2022-03-30

    申请号：EP21192675.3

    申请日：2009-10-21

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin

    IPC分类号： G01N33/68

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Tissue inhibitor of metalloproteinase 2, and optionally further one or more markers of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, S100-A12, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-1 receptor antagonist, Interleukin-1 beta, Interleukin-10, Interleukin-15, Interleukin-3, Myeloperoxidase, Nidogen-1, soluble Oxidized low-density lipoprotein receptor 1, Pappalysin-1, soluble P-selectin glycoprotein ligand 1, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinase 1, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule 1, and Vascular endothelial growth factor A as diagnostic and prognostic biomarkers in renal injuries.

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    34.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开

    公开(公告)号：EP3828544A1

    公开(公告)日：2021-06-02

    申请号：EP20201404.9

    申请日：2012-01-08

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

    IPC分类号： G01N33/53 ,  G01N33/68 ,  C12Q1/6883

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietin-related protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1(XVIII) chain as diagnostic and prognostic biomarkers in renal injuries.

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    40.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    方法和组合物诊断和预后肾损伤和肾功能衰竭的

    公开(公告)号：EP2788759A1

    公开(公告)日：2014-10-15

    申请号：EP12854991.2

    申请日：2012-12-07

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/53

    CPC分类号： G01N33/545 ,  G01N33/6893 ,  G01N2333/4745 ,  G01N2800/26 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Insulin-like growth factor-binding protein 7, Beta-2-glycoprotein 1, Metalloproteinase inhibitor 2, Alpha-1 Antitrypsin, Leukocyte elastase, Serum Amyloid P Component, C-X-C motif chemokine 6, Immunoglobulin A, Immunoglobulin G subclass I, C-C motif chemokine 24, Neutrophil collagenase, Cathepsin D, C-X-C motif chemokine 13, Involucrin, Interleukin-6 receptor subunit beta, Hepatocyte Growth Factor, CXCL-1, -2, -3, Immunoglobulin G subclass II, Metalloproteinase inhibitor 4, C-C motif chemokine 18, Matrilysin, C-X-C motif chemokine 11, and Antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.

    摘要翻译： 本发明涉及用于监测，诊断，预后和治疗方案的测定在脓毒症患者的方法和组合物。 特别地，本发明涉及使用分析并检测选自胰岛素样生长因子结合蛋白7中选择的一个或多个生物标记物，β-2-糖蛋白1，金属蛋白酶抑制剂2，α-1抗胰蛋白酶，白细胞弹性蛋白酶， 血清淀粉样蛋白P成分，CXC基序趋化因子6，免疫球蛋白A，免疫球蛋白G亚类I，CC基序趋化因子24，嗜中性胶原酶，组织蛋白酶D，CXC基序趋化因子13，外皮蛋白，白细胞介素6受体亚基β，肝细胞生长因子，CXCL-1 ，-2，-3，免疫球蛋白G亚类II，金属蛋白酶抑制剂4，CC趋化因子基序18，基质溶素，CXC基序趋化因子11，以及Antileukoproteinase如在脓毒症患者的肾损伤的诊断和预后的生物标志物测定。