公开(公告)号：EP3311158A2

公开(公告)日：2018-04-25

申请号：EP16812566.4

申请日：2016-06-17

申请人： Sera Prognostics, Inc.

发明人： BONIFACE, John, Jay ,  FLEISCHER, Tracey ,  GASSMAN, Andrew ,  FLICK, Jeff ,  BRADFORD, Chad ,  POLPITIYA, Ashoka ,  HICKOK, Durlin Edward ,  KEARNEY, Paul ,  CRITCHFIELD, Gregory Charles

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/158 ,  G01N33/689 ,  G01N2333/4713 ,  G01N2333/4745

摘要： The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.

公开(公告)号：EP3077819A4

公开(公告)日：2017-06-28

申请号：EP14868424

申请日：2014-12-03

申请人： ASTUTE MEDICAL INC ,  UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： MCPHERSON PAUL ,  KELLUM JOHN A

IPC分类号： G01N33/566 ,  A61P13/12

CPC分类号： A61K38/13 ,  A61K31/357 ,  A61K31/366 ,  A61K31/436 ,  A61K31/437 ,  A61K31/453 ,  A61K31/55 ,  A61K31/585 ,  A61K38/1754 ,  A61K38/55 ,  A61K45/06 ,  G01N33/6893 ,  G01N2333/4745 ,  G01N2333/8146 ,  G01N2800/347 ,  G01N2800/50

公开(公告)号：EP2788759A4

公开(公告)日：2015-11-04

申请号：EP12854991

申请日：2012-12-07

申请人： ASTUTE MEDICAL INC

发明人： ANDERBERG JOSEPH ,  GRAY JEFF ,  MCPHERSON PAUL ,  NAKAMURA KEVIN ,  KAMPF JAMES PATRICK

IPC分类号： G01N33/53

CPC分类号： G01N33/545 ,  G01N33/6893 ,  G01N2333/4745 ,  G01N2800/26 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Insulin-like growth factor-binding protein 7, Beta-2-glycoprotein 1, Metalloproteinase inhibitor 2, Alpha-1 Antitrypsin, Leukocyte elastase, Serum Amyloid P Component, C-X-C motif chemokine 6, Immunoglobulin A, Immunoglobulin G subclass I, C-C motif chemokine 24, Neutrophil collagenase, Cathepsin D, C-X-C motif chemokine 13, Involucrin, Interleukin-6 receptor subunit beta, Hepatocyte Growth Factor, CXCL-1, -2, -3, Immunoglobulin G subclass II, Metalloproteinase inhibitor 4, C-C motif chemokine 18, Matrilysin, C-X-C motif chemokine 11, and Antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.

公开(公告)号：EP2899545A1

公开(公告)日：2015-07-29

申请号：EP15151607.7

申请日：2011-06-23

申请人： Astute Medical, Inc.

发明人： Anderberg, Joseph ,  Gray, Jeff ,  McPherson, Paul ,  Nakamura, Kevin ,  Kampf, James Patrick

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6854 ,  G01N33/6863 ,  G01N33/74 ,  G01N2333/4725 ,  G01N2333/4745 ,  G01N2333/495 ,  G01N2333/521 ,  G01N2333/5431 ,  G01N2333/7155 ,  G01N2333/96472 ,  G01N2333/96494 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/56

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of C-C Motif chemokine 24, and optinally Cancer antigen CA 15-3, C-C Motif chemokine 18, , Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.

摘要翻译： 本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用被配置一个或多个测定中，以检测选自CC趋化因子的基序24选择的肾损伤标记物，和optinally癌抗原CA 15-3，CC趋化因子基序18，组织蛋白酶D，CXC 基序趋化因子13，CC基序趋化因子8，白介素-2受体α链，胰岛素样生长因子结合蛋白3，白细胞介素-11，基质金属蛋白酶8，转化生长因子α，IgG1的，和IgG2如在诊断和预后标志物 肾损伤。

公开(公告)号：EP2697654A1

公开(公告)日：2014-02-19

申请号：EP12770850.1

申请日：2012-04-13

申请人： Hytest Ltd.

发明人： KATRUKHA, Alexey G. ,  POSTNIKOV, Alexander B. ,  SMOLYANOVA, Tatiana I. ,  KHARITONOV, Alexey V. ,  TAMM, Natalia N.

IPC分类号： G01N33/68 ,  A61K38/30 ,  A61P9/00

CPC分类号： G01N33/6893 ,  A61K38/1754 ,  G01N2333/4745 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/52 ,  G01N2800/60

摘要： The present invention describes the method for determining the risk of future major adverse cardiovascular events, which comprises detection proteolytic fragments of IGFBP-4 or IGFBP-5 (insulin-like growth factor binding protein 4 or insulin-like growth factor binding protein 5) in patients' blood. The present invention provides antibodies and immunoas-says, suitable for specific measurement of proteolytic fragments of IGFBPs. In current invention the IGFBP fragments are suggested to be utilized as blood biomarkers for the risk prediction of major adverse cardiovascular events (MACE).

公开(公告)号：EP1901074B1

公开(公告)日：2011-07-27

申请号：EP07122125.3

申请日：2005-05-18

申请人： Københavns Universitet ,  Statens Serum Institut ,  Harold Wood Hospital

发明人： Wewer, Ulla M. ,  Christiansen, Michael ,  Frölich, Camilla ,  Laigaard, Jennie ,  Nørgaard-Pedersen, Bent ,  Spencer, Kevin

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/689 ,  G01N2333/4745 ,  G01N2333/96486 ,  G01N2800/36 ,  G01N2800/368 ,  G01N2800/385 ,  G01N2800/387 ,  Y10T436/143333

公开(公告)号：EP1853323A4

公开(公告)日：2010-06-16

申请号：EP06727569

申请日：2006-02-10

申请人： BIOCURE PHARMA LLC

发明人： LEE DAE-YEOL ,  LEE YONG CHUL

IPC分类号： C07K14/47 ,  A61K38/16 ,  A61K48/00 ,  C12N15/63

CPC分类号： C07K14/4743 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/0368 ,  A61K38/1709 ,  A61K48/00 ,  A61K48/005 ,  C12N2710/10043 ,  G01N33/6893 ,  G01N2333/4745 ,  G01N2800/122

公开(公告)号：EP1590664A4

公开(公告)日：2007-05-23

申请号：EP03783356

申请日：2003-11-13

申请人： CIPHERGEN BIOSYSTEMS INC

发明人： BUHIMSCHI IRINA A ,  CHRISTNER ROBERT ,  BUHIMSCHI CATALIN S ,  WEINER CARL P

IPC分类号： G01N33/68 ,  G01N33/48

CPC分类号： G01N33/6893 ,  G01N33/689 ,  G01N2333/471 ,  G01N2333/4745 ,  G01N2333/5752 ,  G01N2333/5756 ,  G01N2333/70539 ,  G01N2333/78 ,  G01N2333/8139 ,  G01N2800/36 ,  G01N2800/368

摘要： Assessing fetal health and maturity, and the integrity and health of the amnion, is effected via protein profiling of vaginal fluid, thereby to identify various abnormal conditions during pregnancy. This approach also provides a means for gauging the duration and/or magnitude of intraamniotic/fetal inflammation that occurs during pregnancy.

公开(公告)号：EP1418433B1

公开(公告)日：2007-01-03

申请号：EP03023863.8

申请日：2003-10-21

申请人： Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH

发明人： Haage, Angelika, Dr.

IPC分类号： G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2333/4745

公开(公告)号：EP1692520A2

公开(公告)日：2006-08-23

申请号：EP04811912.7

申请日：2004-11-19

申请人： Satoris, Inc.

发明人： RAY, Sandip ,  WYSS-CORAY, Anton

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/4745 ,  G01N2800/2821

摘要： The inventors have discovered a collection of proteinaceous biomarkers ('AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.