公开(公告)号：EP2029600A1

公开(公告)日：2009-03-04

申请号：EP07729158.1

申请日：2007-05-15

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： DOLLINGER, Horst ,  MARTYRES, Domnic ,  GOEGGEL, Rolf ,  JUNG, Birgit ,  NICKOLAUS, Peter

IPC分类号： C07D475/08 ,  A61K31/495 ,  A61P11/00 ,  A61P17/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D475/08

摘要： The invention relates to novel pteridines of formula (1), suitable for the treatment of airway or gastrointestinal complaints or diseases, inflammatory diseases of the joints, the skin or eyes, diseases of the peripheral or central nervous systems or cancerous diseases and pharmaceutical compositions comprising said compounds.

公开(公告)号：EP1877376A1

公开(公告)日：2008-01-16

申请号：EP06725750.1

申请日：2006-04-13

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： WALTER, Rainer ,  ANDERSKEWITZ, Ralf ,  KLEY, Jörg ,  DOLLINGER, Horst ,  GOEGGEL, Rolf ,  JUNG, Birgit ,  MACK, Juergen ,  NICKOLAUS, Peter

IPC分类号： C07D209/34 ,  C07D307/83 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/343 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61P1/00

CPC分类号： C07D209/34 ,  C07D307/83 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The invention relates to novel compounds of formula (1), heteroderivatives thereof, and pharmacologically compatible salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, that are suitable for treating respiratory or gastrointestinal complaints or illnesses, inflammatory diseases of the joints, skin or eyes, diseases relating to the peripheral or central nervous system, or cancerous diseases. The invention also relates to pharmaceutical compositions containing said compounds.

公开(公告)号：EP0610487B1

公开(公告)日：1999-11-10

申请号：EP93919208.4

申请日：1993-08-28

申请人： Boehringer Ingelheim Pharma KG ,  Boehringer Ingelheim International GmbH

发明人： ESSER, Franz ,  SCHNORRENBERG, Gerd ,  DOLLINGER, Horst ,  JUNG, Birgit ,  BÜRGER, Erich

IPC分类号： C07K5/06 ,  C07K5/02

CPC分类号： C07K5/06139 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0207 ,  C07K5/021

公开(公告)号：EP0802922A1

公开(公告)日：1997-10-29

申请号：EP95909796.0

申请日：1995-03-02

申请人： BOEHRINGER INGELHEIM KG ,  BOEHRINGER INGELHEIM INTERNATIONAL GmbH

发明人： ESSER, Franz ,  SCHNORRENBERG, Gerd ,  DOLLINGER, Horst ,  JUNG, Birgit ,  BUERGER, Erich ,  SPECK, Georg

IPC分类号： A61K38 ,  A61P1 ,  A61P17 ,  A61P29 ,  C07D215 ,  C07D401 ,  C07D491 ,  C07K5

CPC分类号： C07D215/38 ,  A61K38/00 ,  C07D401/14 ,  C07D491/04 ,  C07K5/0202 ,  C07K5/06139 ,  C07K5/06165

摘要： The invention concerns novel amino acid derivatives of general formula (I) and their pharmaceutically acceptable salts, in which the R2 group is (II) and R1, A, G, Y, Z and m have the meanings given in the description, and their production and use. The novel compounds are valuable neurokinin (tachykinin) antagonists.