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1.发明授权NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3) 有权哌啶取代的吲哚衍生物或其HETERO及其作为趋化因子受体（CCR-3）调节剂
公开(公告)号：EP1687294B1
公开(公告)日：2014-05-21
申请号：EP04818773.6
申请日：2004-11-11
发明人： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D401/04 , A61K31/454 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： C07D413/14 , A61K31/454 , A61K31/496 , C07D401/04 , C07D401/14 , C07D417/14 , C07D471/04 , C07D513/04
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公开(公告)号：EP1776356B1
公开(公告)日：2008-09-17
申请号：EP05778384.7
申请日：2005-07-30
IPC分类号： C07D401/06 , A61K31/445 , A61K31/4184 , A61P37/08
CPC分类号： C07D401/06
摘要： A compound of general formula (1a) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1877376A1
公开(公告)日：2008-01-16
申请号：EP06725750.1
申请日：2006-04-13
发明人： WALTER, Rainer , ANDERSKEWITZ, Ralf , KLEY, Jörg , DOLLINGER, Horst , GOEGGEL, Rolf , JUNG, Birgit , MACK, Juergen , NICKOLAUS, Peter
IPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , A61K31/343 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/425 , A61P1/00
CPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel compounds of formula (1), heteroderivatives thereof, and pharmacologically compatible salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, that are suitable for treating respiratory or gastrointestinal complaints or illnesses, inflammatory diseases of the joints, skin or eyes, diseases relating to the peripheral or central nervous system, or cancerous diseases. The invention also relates to pharmaceutical compositions containing said compounds.
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4.发明公开CYANOTHIOPHENE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开Cyanothiophenes其制备及其作为药物
公开(公告)号：EP1807411A1
公开(公告)日：2007-07-18
申请号：EP05797301.8
申请日：2005-10-18
发明人： ANDERSKEWITZ, Ralf , MORSCHHÄUSER, Gerd , STREICHER, Rüdiger , TRIESELMANN, Thomas , WALTER, Rainer
IPC分类号： C07D333/38 , A61K31/381 , A61P3/10
CPC分类号： C07D333/38 , C07D409/12
摘要： The invention relates to cyanothiophenes of general formula (I), in which the R's are defined in the claims, and relates to their tautomers, stereoisomers, mixtures and salts that have valuable pharmacological properties, in particular, a glucagon receptor-antagonistic action.
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公开(公告)号：EP1776356A1
公开(公告)日：2007-04-25
申请号：EP05778384.7
申请日：2005-07-30
IPC分类号： C07D401/06 , A61K31/445 , A61K31/4184 , A61P37/08
CPC分类号： C07D401/06
摘要： A compound of general formula (1a) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP2970252B1
公开(公告)日：2020-06-03
申请号：EP14713395.3
申请日：2014-03-12
发明人： ANDERSKEWITZ, Ralf , GRAUERT, Matthias , GRUNDL, Marc , OOST, Thorsten , PAUTSCH, Alexander , PETERS, Stefan
IPC分类号： C07D453/06 , A61K31/439 , A61P11/00 , A61P19/00 , A61P37/08
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公开(公告)号：EP3174879B1
公开(公告)日：2018-07-18
申请号：EP15739650.8
申请日：2015-07-28
发明人： GRAUERT, Matthias , ANDERSKEWITZ, Ralf , BIXENMANN, Achim , GRUNDL, Marc , HAEBEL, Peter Wilhelm , PAUTSCH, Alexander
IPC分类号： C07D471/08 , A61K31/439 , A61P11/00
CPC分类号： C07D405/12 , A61K31/403 , A61K31/407 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D405/14 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10
摘要： This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
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8.发明公开SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY 审中-公开取代的双环二氢嘧啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的应用
公开(公告)号：EP3174861A1
公开(公告)日：2017-06-07
申请号：EP15744229.4
申请日：2015-07-30
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , GNAMM, Christian , HOESCH, Holger , MORSCHHAEUSER, Gerd , PETERS, Stefan , RIES, Uwe Joerg
IPC分类号： C07D239/70 , A61K31/517 , A61P29/00
CPC分类号： C07D239/70 , C07D401/04
摘要： Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD. An exemplary compound is:
摘要翻译： 式1的取代的双环二氢嘧啶酮是嗜中性粒细胞弹性蛋白酶的抑制剂并且可用作用于治疗COPD等的药物。 示例性化合物是：
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9.发明授权SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C 有权取代的2-氮杂双环[2.2.1]庚烷-3-羧酸（氰基 - 甲基） - 酰胺类抑制剂
公开(公告)号：EP2970228B1
公开(公告)日：2017-05-10
申请号：EP14709317.3
申请日：2014-03-12
IPC分类号： C07D405/14 , A61K31/439 , C07D221/22 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/08 , A61P11/06 , A61P37/08 , A61P37/06 , A61P9/10
CPC分类号： C07D409/12 , A61K45/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP2528901B9
公开(公告)日：2017-01-25
申请号：EP11701796.2
申请日：2011-01-24
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D401/06 , C07D405/12 , C07D231/12 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： C07D231/12 , C07D401/06 , C07D405/12
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