ALBUMIN NANOPARTICLES ENCAPSULATING GADOLINIUM AND METHOD OF SYNTHESIS THEREOF
    33.
    发明公开
    ALBUMIN NANOPARTICLES ENCAPSULATING GADOLINIUM AND METHOD OF SYNTHESIS THEREOF 审中-公开
    包埋钆的白蛋白纳米颗粒及其合成方法

    公开(公告)号:EP3233135A1

    公开(公告)日:2017-10-25

    申请号:EP15825836.8

    申请日:2015-12-14

    IPC分类号: A61K49/14 A61K49/18 B82Y15/00

    CPC分类号: A61K49/143 A61K49/1818

    摘要: The invention relates to cross-linked albumin nanoparticles loaded with gadolinium, for example with GdCl3 or Gd-DTPA, characterized in that they have a controlled size comprised between 50 nm and 80 nm, and that the gadolinium molecules are encapsulated by albumin, without the presence of covalent or electrostatic bonds. The gadolinium thus encapsulated has a relaxivity value greater than the reference molecules currently used for MRI diagnostics. The method of synthesis of the nanoparticles of the invention is also described.

    摘要翻译: 本发明涉及负载有钆的交联白蛋白纳米颗粒,例如GdCl 3或Gd-DTPA,其特征在于它们具有包括在50nm和80nm之间的受控尺寸,并且钆分子被白蛋白包封,没有 共价键或静电键的存在。 如此封装的钆具有比当前用于MRI诊断的参考分子更大的弛豫值。 还描述了合成本发明纳米颗粒的方法。