公开(公告)号：EP1362916A3

公开(公告)日：2004-02-18

申请号：EP03012254.3

申请日：1996-03-14

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Yu, Guo-Liang ,  Gentz, Reiner L. ,  Dillon, Patrick J.

IPC分类号： C07K14/525

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：EP1247862A2

公开(公告)日：2002-10-09

申请号：EP02001060.9

申请日：1997-08-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Duan, Roxanne D. ,  Ruben, Steven M. ,  Jimenez, Pablo ,  Rampy, Mark, A. ,  Mendrick, Donna ,  Zhang, Jun ,  Ni, Jian ,  Moore, Paul A. ,  Coleman, Timothy, A. ,  Gentz, Reiner L.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C07K14/50 ,  C07K16/22 ,  A61K38/18 ,  A61K48/00 ,  G01N33/566

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：EP1247530A2

公开(公告)日：2002-10-09

申请号：EP02001059.1

申请日：1997-08-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Duan, Roxanne D. ,  Ruben, Steven M. ,  Jimenez, Pablo ,  Rampy, Mark A. ,  Mendrick, Donna ,  Zhang, Jun ,  Ni, Jian ,  Moore, Paul A. ,  Coleman, Timothy A. ,  Gentz, Reiner L.

IPC分类号： A61K38/18

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 刺激角质化细胞增殖的新的分离多肽选自：（I）角质形成细胞生长因子-2（KGF-2）N-末端，C-末端或N-末端和C-末端缺失突变体，其分别包含208 氨基酸序列（A;在说明书中给出），除了至少缺失：（a）（A）的前38个但不多于第一个137个N-末端氨基酸残基; （b）最后的C末端氨基酸残基（Ser208），但不超过最后55个C末端氨基酸残基，其中KGF-2 C-末端缺失突变体的N-末端氨基酸残基为Met1，Thr36 或Cys37; （c）（a）和（b）的组合; 或（II）除了至少一个氨基酸取代之外，与（I）具有至少95％氨基酸同一性或与（I）相同的多肽。 还要求的是：（1）包含KGF-2的亲水区域的分离的多肽，其中所述肽的长度不超过150个氨基酸，并且包含残基41-71,91-109,135-164或181-199 （一个）; （2）编码上述多肽的分离的多核苷酸; （3）制备重组载体的方法，包括将（2）插入载体; （4）通过（3）的方法制备的重组载体; （5）一种制备重组宿主细胞的方法，包括将载体导入宿主细胞; 和（6）通过（5）的方法制备的重组宿主细胞。

公开(公告)号：EP1171579A1

公开(公告)日：2002-01-16

申请号：EP00914975.8

申请日：2000-03-16

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Gentz, Reiner L. ,  Yu, Guo-Liang ,  Fan, Ping

IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K16/24

CPC分类号： C07K14/70578 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

摘要翻译： 本发明涉及肿瘤坏死因子受体家族的新成员。 具体而言，提供了编码人TR9受体的分离的核酸分子。 还提供TR9多肽以及载体，宿主细胞和用于生产TR9多肽的重组方法。 本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。