公开(公告)号：EP2431054A2

公开(公告)日：2012-03-21

申请号：EP10011219.2

申请日：2001-06-14

申请人： Human Genome Sciences, Inc.

发明人： Yu, Guo-Liang ,  Ni, Jian ,  Gentz, Reiner L. ,  Dillon, Patrick J.

IPC分类号： A61K47/00 ,  A61K47/48 ,  A61K49/00 ,  C07K14/52 ,  C07K14/705 ,  C07K16/28 ,  G01N33/564

CPC分类号： A61K49/0004 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，用于产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：EP1655382A3

公开(公告)日：2006-05-17

申请号：EP05027607.0

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Soppet, Daniel R. ,  Li, Yi ,  Dillon, Patrick J.

IPC分类号： C12Q1/70 ,  G01N33/53 ,  C12N15/00 ,  C12N1/20 ,  C12N1/14 ,  C12N5/00 ,  C07K1/00 ,  C12P21/08 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/57419 ,  A61K38/00 ,  C07K14/47 ,  C12N2799/026

摘要： Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

公开(公告)号：EP1362916A2

公开(公告)日：2003-11-19

申请号：EP03012254.3

申请日：1996-03-14

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Yu, Guo-Liang ,  Gentz, Reiner L. ,  Dillon, Patrick J.

IPC分类号： C12N15/28 ,  C12N15/62 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/525 ,  C07K16/24 ,  A61K31/713 ,  A61K38/19 ,  G01N33/53

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，用于产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：EP1362916A3

公开(公告)日：2004-02-18

申请号：EP03012254.3

申请日：1996-03-14

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Ni, Jian ,  Yu, Guo-Liang ,  Gentz, Reiner L. ,  Dillon, Patrick J.

IPC分类号： C07K14/525

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：EP0786519A2

公开(公告)日：1997-07-30

申请号：EP97100117.7

申请日：1997-01-07

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Kunsch, Charles A. ,  Choi, Gil H. ,  Barash, Steven C. ,  Dillon, Patrick J. ,  Fannon, Michael R. ,  Rosen, Craig A.

IPC分类号： C12N15/00

CPC分类号： C12N15/1093 ,  A61K39/00 ,  C07K14/31 ,  C12N15/52

摘要： The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

摘要翻译： 本发明提供金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明进一步提供存储在计算机可读介质上的多核苷酸和多肽序列信息以及便于其使用的基于计算机的系统和方法。

公开(公告)号：EP1655382A2

公开(公告)日：2006-05-10

申请号：EP05027607.0

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Soppet, Daniel R. ,  Li, Yi ,  Dillon, Patrick J.

IPC分类号： C12Q1/70 ,  G01N33/53 ,  C12N15/00 ,  C12N1/20 ,  C12N1/14 ,  C12N5/00 ,  C07K1/00 ,  C12P21/08 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/57419 ,  A61K38/00 ,  C07K14/47 ,  C12N2799/026

摘要： Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

摘要翻译： 公开了人结肠特异性基因多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸或多肽作为结肠癌的诊断标记物和用作确定结肠癌是否转移的药剂的方法。 还公开了可用于靶向癌细胞并用作结肠癌疫苗一部分的结肠特异性基因多肽特异性抗体。 还公开了筛选多肽的激动剂和拮抗剂的方法以及拮抗剂的治疗用途。

公开(公告)号：EP1428833A2

公开(公告)日：2004-06-16

申请号：EP04001119.9

申请日：1998-06-04

申请人： Human Genome Sciences, Inc.

发明人： Young, Paul ,  Greene, John M. ,  Ferrie, Ann M. ,  Ruben, Steven M. ,  Rosen, Craig A. ,  Hu, Jing-Shan ,  Olsen, Henrik S. ,  Ebner, Reinhard ,  Brewer, Laurie A. ,  More, Paul A. ,  Shi, Yanggu ,  Florence, Charles ,  Florence, Kimberly ,  LaFleur, David W. ,  Ni, Jian ,  Fan, Ping ,  Wei, Ying-Fei ,  Fischer, Carrie L. ,  Soppet, Daniel R. ,  Li, Yi ,  Zeng, Zhizhen ,  Kyaw, Hla ,  Yu, Guo-Liang ,  Feng, Ping ,  Dillon, Patrick J. ,  Endress, Gregory A. ,  Carter, Kenneth C.

IPC分类号： C07K14/435 ,  C12N1/20 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  G01N33/53 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regionsof the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：EP2431054A3

公开(公告)日：2013-03-06

申请号：EP10011219.2

申请日：2001-06-14

申请人： Human Genome Sciences, Inc.

发明人： Yu, Guo-Liang ,  Ni, Jian ,  Gentz, Reiner L. ,  Dillon, Patrick J.

IPC分类号： A61K47/00 ,  A61K47/48 ,  A61K49/00 ,  C07K14/52 ,  C07K14/705 ,  C07K16/28 ,  G01N33/564

CPC分类号： A61K49/0004 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：EP1323824A3

公开(公告)日：2004-01-21

申请号：EP03006708.6

申请日：1995-02-14

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Gruber, Joachim R. ,  Dillon, Patrick J.

IPC分类号： C12N15/12 ,  C07K14/475 ,  C12N5/10 ,  C07K16/22 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  A61K38/18 ,  A61K48/00 ,  A61P17/00

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026

摘要： A human polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating epithelial cell growth which may be used to stimulate wound healing, reduce scarring and prevent hair loss. Antagonists against such polypeptides and their use as a therapeutic to treat proliferative diseases such as cancer, psoriasis, Kaposi's sarcoma, keloids, retinopathy and restenosis are also disclosed. Diagnostic methods for detecting mutations in the KGF-2 coding sequence and alterations in the concentration of KGF-2 protein in a sample derived from a host are also disclosed.