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公开(公告)号：EP2172212A2
公开(公告)日：2010-04-07
申请号：EP08017921.1
申请日：2008-10-13
发明人： Schoor, Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen , Singh, Harpreet
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/06 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 25 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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32.发明公开Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers 有权胶质母细胞瘤（GBM）的治疗的肿瘤相关肽及相关的抗癌疫苗和其它癌症的组合物
公开(公告)号：EP2172211A1
公开(公告)日：2010-04-07
申请号：EP08017305.7
申请日：2008-10-01
发明人： Schoor, Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen , Singh, Harpreet
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/06 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.
摘要翻译： 本发明涉及免疫治疗肽及其在免疫疗法中的使用，在癌症特别是免疫疗法。 本发明的圆盘更小的肿瘤相关T辅助细胞肽表位，单独或与其它肿瘤相关肽组合确实起到疫苗组合物，其刺激抗肿瘤免疫应答的作为活性药物成分。 特别地，本发明的肽的组合物可以在疫苗组合物可用于针对神经胶质瘤引发抗肿瘤免疫应答。
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公开(公告)号：EP3539979A2
公开(公告)日：2019-09-18
申请号：EP19166517.3
申请日：2014-11-03
发明人： Weinschenk, Toni , Fritsche, Jens , Walter, Steffen , Hilf, Norbert , Schoor, Oliver , Singh, Harpreet , Kuttruff-Coqui, Sabrina , Song, Colette
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：EP3069728B1
公开(公告)日：2018-11-14
申请号：EP16165070.0
申请日：2009-09-28
发明人： Schoor, Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen , Singh, Harpreet
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 25 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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35.发明公开
公开(公告)号：EP3363456A1
公开(公告)日：2018-08-22
申请号：EP18156634.0
申请日：2011-03-15
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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36.发明公开
公开(公告)号：EP3329933A1
公开(公告)日：2018-06-06
申请号：EP17203096.7
申请日：2011-03-15
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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37.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER 审中-公开新型免疫治疗包括胃肠和胃癌在内的多种肿瘤
公开(公告)号：EP3195873A1
公开(公告)日：2017-07-26
申请号：EP17157398.3
申请日：2011-03-15
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 具体而言，本发明涉及癌症的免疫治疗。 本发明还涉及单独或与其他肿瘤相关肽组合的肿瘤相关的细胞毒性T细胞（CTL）肽表位，所述肽用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分。 本发明涉及95种新的肽序列及其衍生自人肿瘤细胞的HLA I类分子的变体，其可用于引发抗肿瘤免疫应答的疫苗组合物中。
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38.发明授权Novel immunotherapy against several tumors including gastrointestinal and gastric cancer 有权针对几种肿瘤的新型免疫疗法，包括胃肠道癌和胃癌
公开(公告)号：EP2923708B1
公开(公告)日：2017-07-12
申请号：EP15154344.4
申请日：2011-03-15
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 具体而言，本发明涉及癌症的免疫治疗。 本发明还涉及单独或与其他肿瘤相关肽组合的肿瘤相关的细胞毒性T细胞（CTL）肽表位，所述肽用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分。 本发明涉及95种新的肽序列及其衍生自人肿瘤细胞的HLA I类分子的变体，其可用于引发抗肿瘤免疫应答的疫苗组合物中。
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39.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 审中-公开新型免疫疗法针对不同肿瘤，包括神经和脑肿瘤
公开(公告)号：EP3106175A1
公开(公告)日：2016-12-21
申请号：EP16179163.7
申请日：2009-09-28
发明人： Schoor, Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen , Singh, Harpreet
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：EP3042914A1
公开(公告)日：2016-07-13
申请号：EP15193843.8
申请日：2008-07-25
发明人： Singh, Harpreet , Schoor, Oliver , Trautwein, Claudia , Hilf, Norbert , Weinschenk, Toni , Walter, Steffen , Lewandrowski, Peter
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to amino acid sequences of peptides derived from tumour associated antigens that are able to bind to MHC complexes of either class, and elicit an immune response, as well as to uses of said peptides for the treatment of diseases.
摘要翻译： 本发明涉及能够结合任一类MHC复合物并引发免疫应答的衍生自肿瘤相关抗原的肽的氨基酸序列，以及所述肽用于治疗疾病的用途。
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