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公开(公告)号：EP3069728B1
公开(公告)日：2018-11-14
申请号：EP16165070.0
申请日：2009-09-28
发明人： Schoor, Oliver , Hilf, Norbert , Weinschenk, Toni , Trautwein, Claudia , Walter, Steffen , Singh, Harpreet
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 25 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：EP3380120A1
公开(公告)日：2018-10-03
申请号：EP16801468.6
申请日：2016-11-25
IPC分类号： A61K39/385 , A61K39/00
CPC分类号： A61K39/385 , A61K2039/55511 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/6093
摘要： The invention relates to the use of melanin, complexed with an antigen, as a immunostimulatory composition.
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公开(公告)号：EP3352783A1
公开(公告)日：2018-08-01
申请号：EP16838065.7
申请日：2016-09-26
申请人： MaxiVax SA
发明人： MACH, Nicolas
CPC分类号： A61K39/0011 , A61K9/0019 , A61K9/4891 , A61K39/39 , A61K45/06 , A61K2039/515 , A61K2039/5152 , A61K2039/54 , A61K2039/55522 , A61K2039/6093 , A61M5/178 , A61M2202/30 , C12N5/0693 , C12P21/005 , Y02A50/412
摘要： Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as GM-C SF (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or preventative vaccination against tumors or infectious agents.
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公开(公告)号：EP2262480B1
公开(公告)日：2018-02-14
申请号：EP09717401.5
申请日：2009-03-04
发明人： HUBBY, Bolyn , MURPHY, Andrew , KINDIG, Jeff , WHITE, Jesse , ROTH, Samantha , GALLOWAY, Ashley , COPP, Laura
IPC分类号： A61K39/385
CPC分类号： A61K39/39 , A61K39/385 , A61K47/646 , A61K47/6927 , A61K47/6931 , A61K47/6937 , A61K2039/55538 , A61K2039/6093 , A61K2039/627
摘要： A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulating an immune response in a subject including administering to the subject a plurality of particles, wherein each particle is coupled with an immuno stimulating agent and a protein. A vaccine particle composition including a plurality of particles configured to release a first protein at a first rate and a second protein at a second rate and configured to provide priming and boosting capability in a single dose.
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公开(公告)号：EP2440245B1
公开(公告)日：2017-12-06
申请号：EP10727594.3
申请日：2010-06-10
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
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公开(公告)号：EP3104882A4
公开(公告)日：2017-11-22
申请号：EP15749237
申请日：2015-02-17
申请人： CENTROSE LLC
发明人： PRUDENT JAMES R
CPC分类号： A61K47/48561 , A61K47/48384 , A61K47/48715 , A61K47/6803 , A61K47/6849 , A61K47/6889 , A61K2039/6093 , C07K16/2896 , C07K2319/01 , C07K2319/035
摘要： Extracellular drug conjugates (EDCs) targeting CD38 are useful in the treatment of diseases such as cancer and immune disorders, including asthma.
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公开(公告)号：EP3107568A4
公开(公告)日：2017-10-11
申请号：EP15752216
申请日：2015-02-20
申请人： VAXART INC
发明人： TUCKER SEAN , TRAGER GEORGE
IPC分类号： A61K39/00 , A61K31/7088 , A61K31/713
CPC分类号： A61K9/2846 , A61K31/7088 , A61K31/713 , A61K2039/6093 , C12N2760/16134
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8.发明授权
公开(公告)号：EP1420815B2
公开(公告)日：2017-08-09
申请号：EP02758181.8
申请日：2002-08-20
申请人： H. Lundbeck A/S
发明人： RASMUSSEN, Peter Birk Pharmexa A/S , JENSEN, Martin Roland Pharmexa A/S , NIELSEN, Klaus Gregorius Pharmexa A/S , KOEFOED, Peter Pharmexa A/S , DEGAN, Florence Dal Pharmexa A/S
IPC分类号： A61K39/00 , A61K39/385 , C07K14/47 , A61P25/28
CPC分类号： A61K39/0007 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A61K39/385 , A61K45/06 , A61K2039/53 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64 , C07K14/4711 , Y02A50/412
摘要： Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (A²). Immunization is preferably effected by administration of analogues of autologous APP or A², said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A² which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A² and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations
摘要翻译： 公开了用于对抗以淀粉样蛋白沉积为特征的疾病的新方法。 这些方法通常依赖于针对淀粉样前体蛋白（APP）或β淀粉样蛋白（A 2）的免疫接种。 免疫优选通过施用自体APP或A 2类似物来实现，所述类似物能够诱导针对自体致淀粉状蛋白产生多肽的抗体产生。 特别优选作为免疫原的是自体A 2，其通过引入一个或几个外来免疫显性和混杂T细胞表位而被修饰。 还公开了针对APP或A 2的核酸疫苗接种和使用活疫苗的疫苗接种以及用于疫苗接种的方法和手段。 这样的方法和手段包括制备类似物和药物制剂的方法，以及核酸片段，载体，转化的细胞，多肽和药物制剂
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公开(公告)号：EP2961423B1
公开(公告)日：2017-07-26
申请号：EP14706650.0
申请日：2014-02-26
CPC分类号： A61K47/545 , A61K9/0019 , A61K9/1075 , A61K39/0005 , A61K39/39 , A61K47/60 , A61K47/61 , A61K47/6905 , A61K47/6911 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55583 , A61K2039/57 , A61K2039/572 , A61K2039/6093 , A61K2039/627 , A61K2039/645 , C07K16/02 , C07K16/2863 , C07K2317/10 , C07K2317/21 , Y02A50/41 , Y02A50/412 , Y02A50/414
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公开(公告)号：EP2347774B1
公开(公告)日：2017-07-26
申请号：EP10194626.7
申请日：2006-12-13
发明人： Mooney, David , Ali, Omar, Abdel-Rahman , Barros e Silva, Eduardo Alexandre , Kong, Hyun, Joon , Hill, Elliott, Earl , Boontheeknul, Tanyarut
CPC分类号： A61K39/0011 , A61K9/0024 , A61K9/1647 , A61K38/1866 , A61K38/193 , A61K38/39 , A61K39/21 , A61K39/39 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55583 , A61K2039/6093 , A61L27/18 , A61L27/20 , A61L27/3633 , A61L27/38 , A61L27/3826 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/232 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/438 , A61L2300/604 , A61L2300/606 , A61L2400/18 , A61L2430/30 , A61L2430/34 , B33Y80/00 , C12N7/00 , C12N15/117 , C12N2310/17 , C12N2320/32 , C12N2740/16034 , Y02A50/411
摘要： A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
摘要翻译： 包括支架组合物和生物活性组合物的装置，其中生物活性组合物被引入或涂覆到支架组合物上，使得支架组合物和/或生物活性组合物控制静止细胞或其后代的出口。 这些装置介导从材料中主动募集，修饰和释放宿主细胞。
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