公开(公告)号：EP1032443A1

公开(公告)日：2000-09-06

申请号：EP98951283.5

申请日：1998-10-26

申请人： NOVO NORDISK A/S

发明人： JENSEN, Jens, Moller ,  BUCH-RASMUSSEN, Thomas ,  POULSEN, Jens, Ulrik

IPC分类号： A61M5/178 ,  A61M5/315

CPC分类号： A61M5/31511 ,  A61M5/284 ,  A61M5/288 ,  A61M5/3129 ,  A61M5/31551 ,  A61M5/31561 ,  A61M5/31563 ,  A61M2005/3103

摘要： A cylinder ampoule (1) having a first end sealed by a closure through which an injection unit can communicate with a medicament in the ampoule and a second end closed by a piston (3) which can be forced into the ampoule (1) to press out a dose of a medicament stored in the ampoule between the closure and the piston (3) through said injection unit, which cylinder ampoule (1) has a not circular inner cross section and which piston (3) has a not circular cross section corresponding to the inner cross section of the ampoule (1). A piston rod (4) has a pressure foot (5) which has a cross section corresponding to the inner cross section of the ampoule (1) and is inrotateably connected to the piston rod (4).

摘要翻译： 1。一种圆筒安瓿（1），具有由封闭件密封的第一端，注射单元可通过该封闭件与安瓿中的药剂连通，第二端由可被迫进入安瓿（1）的活塞（3）封闭以按压 （1）具有非圆形的内横截面，并且该活塞（3）具有相应的非圆形横截面，所述注射单元通过所述注射单元从封闭件和活塞（3）之间的安瓿中取出储存在安瓿中的一定剂量的药物， 到安瓿（1）的内横截面。 活塞杆（4）具有压力支脚（5），其具有与安瓿（1）的内横截面相对应的横截面并且与活塞杆（4）可旋转地连接。

公开(公告)号：EP0996476A1

公开(公告)日：2000-05-03

申请号：EP98933562.5

申请日：1998-07-01

申请人： NOVO NORDISK A/S

发明人： POULSEN, Jens, Ulrik ,  JENSEN, Jens, Moller

IPC分类号： A61M5/24

CPC分类号： A61M5/3158 ,  A61M5/31525 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31561 ,  A61M5/3202 ,  A61M5/50 ,  A61M2205/582

摘要： By a cylinder ampoule (1), comprising a tubular vessel with a membrane (4) sealingly closing one end and a piston (9) closing the other end, liquid stored between said piston (9) and said membrane (4) can be pressed out through an injection needle (7) piercing the membrane (4) when the piston (9) is pressed into the ampoule (1). The tube is made from a plastically deformable material. A pressure foot (10) on which a piston rod (13) is acting abuts the piston (9), carries a spring plate (11) made from a harder material than is the ampoule (1), is mainly perpendicular to the ampoule (1) axis, and has at least one diameter which is larger than the inner diameter of the ampoule (1) so that edges of the plate (11) abutting the inner wall of the ampoule (1) are deflected away from the piston (9) to form an acute angle with said wall. The ampoule (1) has an extension (14) beyond the position of the piston (9) by a full ampoule (1) and forms a part of a pen shaped syringe further comprising a dose setting and injection means co-operating with the piston rod (13).

公开(公告)号：EP0927055A1

公开(公告)日：1999-07-07

申请号：EP97918919.0

申请日：1997-09-16

申请人： NOVO NORDISK A/S

发明人： BUCH-RASMUSSEN, Thomas ,  POULSEN, Jens, Ulrik ,  LJUNGGREEN, Henrik ,  JENSEN, Jens, Moller

IPC分类号： A61M5 ,  A61M39

CPC分类号： A61M5/31525 ,  A61M5/204 ,  A61M5/31555 ,  A61M5/31561 ,  A61M5/3158 ,  A61M5/31595

摘要： A drug delivery system, comprising a reservoir from which set doses are apportioned, a dose setting mechanism by which the relative position of two elements is changed by a distance proportional with a set dose, and a push button by activation of which an element is moved a distance corresponding to said distance proportional with the set dose, further comprises a working cylinder having an open end into which a plunger fits, and a closed end at which an inlet and an outlet port connect the space beneath the plunger with an inlet communicating with the reservoir and an outlet communicating with a drug delivery member, respectively. Valve means at the inlet and outlet controls the passages from the reservoir to the working cylinder and from the working cylinder to the drug delivery member, respectively. The cylinder with the plunger, and the injection member are independently exchangeable, disposable parts.

公开(公告)号：EP0910419A2

公开(公告)日：1999-04-28

申请号：EP97928121.0

申请日：1997-06-09

申请人： NOVO NORDISK A/S

发明人： POULSEN, Jens, Ulrik ,  LJUNGGREEN, Henrik ,  CHRISTENSEN, Lars, Hofmann

IPC分类号： A61M5

CPC分类号： A61M5/20 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/31525 ,  A61M5/31546 ,  A61M2005/31588 ,  A61M2205/581 ,  G06F19/00 ,  Y10S128/01

摘要： The present invention relates to a drug delivery device wherein a dose to be apportioned from a cartridge is set by changing the relative position of co-operating dose setting elements (3, 5) and is injected by pressing a button (5) until this button abuts a stop (6). By operation of count up (7) or count down (8) buttons the dose is set and read into an electronic circuit (9) comprising a microprocessor and the dose setting movement of the dose setting elements relative to each other is performed by a motor (11) controlled by the circuit in accordance with the read in dose. The set dose is shown on a display (10). The motor (11) is further controlled to perform certain movements of the piston rod (3) so as retraction of this rod when a cartridge (1) is going to be changed an advancing of the piston rod to abutment with the piston (2) after the cartridge has been changed and further to advance this piston to expel air from the cartridge.

摘要翻译： 在药物输送装置中，通过改变协同操作的剂量设定元件（3,5）的相对位置来设定从药筒分配的剂量，并且通过按压按钮（5）来注射剂量，直到该按钮抵靠止挡（6 ）。 通过向上计数（7）或向下计数（8）按钮的操作，将剂量设定并读入包括微处理器的电子电路（9），并且剂量设定元件相对于彼此的剂量设定移动由马达 （11）根据读入的剂量由电路控制。 设定的剂量显示在显示器（10）上。 进一步控制马达（11）以执行活塞杆（3）的某些运动，以便在将活塞杆（1）推进到与活塞（2）邻接时改变药筒（1）时缩回该杆， 在墨盒已经改变之后并进一步推进该活塞以从墨盒排出空气。