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公开(公告)号：EP4276114A3
公开(公告)日：2024-02-21
申请号：EP23178961.1
申请日：2017-03-07
申请人： VIB VZW , Universiteit Gent
IPC分类号： A61K38/00 , A61K39/395 , A61K31/00 , C07K14/715 , C07K16/28 , C07K16/30
摘要： The present application relates, in part, to agents that bind CD20 and their use as therapeutic agents. The present application further relates to pharmaceutical compositions comprising the CD20 binding agents and their use in the treatment of various diseases.
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公开(公告)号：EP4276114A2
公开(公告)日：2023-11-15
申请号：EP23178961.1
申请日：2017-03-07
申请人： VIB VZW , Universiteit Gent
IPC分类号： C07K16/30
摘要： The present application relates, in part, to agents that bind CD20 and their use as therapeutic agents. The present application further relates to pharmaceutical compositions comprising the CD20 binding agents and their use in the treatment of various diseases.
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公开(公告)号：EP3411407A1
公开(公告)日：2018-12-12
申请号：EP17705564.7
申请日：2017-02-06
发明人： KLEY, Nikolai , TAVERNIER, Jan , VAN LINT, Sandra , CAUWELS, Anje
IPC分类号： C07K16/28
CPC分类号： C07K16/2851 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K2039/57 , C07K14/00 , C07K14/7156 , C07K16/00 , C07K16/249 , C07K16/2815 , C07K16/2818 , C07K16/2827 , C07K16/2887 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/66 , C07K2317/90 , C07K2319/00 , Y02A50/412
摘要： The present invention relates, in part, to agents that bind Clec9Aand their use as diagnostic and therapeutic agents.The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
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公开(公告)号：EP3411398A2
公开(公告)日：2018-12-12
申请号：EP17704697.6
申请日：2017-02-06
发明人： TAVERNIER, Jan , KLEY, Nikolai
CPC分类号： C07K16/2851 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K2039/57 , C07K14/00 , C07K14/7156 , C07K16/00 , C07K16/249 , C07K16/2815 , C07K16/2818 , C07K16/2827 , C07K16/2887 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/66 , C07K2317/90 , C07K2319/00 , Y02A50/412
摘要： The present invention relates, in part, to agents that bind Clec9Aand their use as diagnostic and therapeutic agents.The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
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35.发明公开VIRUS-LIKE PARTICLE (VLP) BASED SMALL MOLECULE-PROTEIN INTERACTION TRAP 审中-公开基于病毒样粒子（VLP）的小分子蛋白质相互作用蛋白分子
公开(公告)号：EP3274722A1
公开(公告)日：2018-01-31
申请号：EP16711005.5
申请日：2016-03-23
申请人： VIB VZW , Universiteit Gent
发明人： TAVERNIER, Jan , EYCKERMAN, Sven
IPC分类号： G01N33/68 , C12N7/00 , C07K14/005
CPC分类号： G01N33/5436 , C07K14/005 , C07K2319/43 , C07K2319/735 , C12N7/00 , C12N9/003 , C12N2740/16023 , C12N2740/16042 , C12N2740/16222 , G01N33/54313 , G01N33/54353 , G01N33/6803 , G01N33/6845 , G01N33/6848 , G01N2333/161 , G01N2333/90666
摘要： This disclosure relates to a virus-like particle in which a small molecule-protein complex is entrapped, ensuring the formation of the small molecule-protein complex under physiological conditions, while protecting the small molecule-protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation and identification of small molecule-protein complexes.
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公开(公告)号：EP4421094A3
公开(公告)日：2024-11-06
申请号：EP24168089.1
申请日：2017-02-06
发明人： TAVERNIER, Jan , KLEY, Nikolai
摘要： The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.
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公开(公告)号：EP4421094A2
公开(公告)日：2024-08-28
申请号：EP24168089.1
申请日：2017-02-06
发明人： TAVERNIER, Jan , KLEY, Nikolai
IPC分类号： C07K16/28
CPC分类号： A61K38/00 , A61K39/395 , C07K14/7156 , C07K16/00 , C07K16/249 , C07K16/2818 , C07K16/2827 , C07K16/2851 , C07K16/2887 , A61K2039/50520130101 , A61K2039/5720130101 , C07K2317/3120130101 , C07K2317/3320130101 , C07K2317/62220130101 , C07K2317/6620130101 , C07K2317/9020130101 , C07K2319/0020130101 , C07K16/2815 , A61P35/00 , A61P25/28
摘要： The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.
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公开(公告)号：EP4178609A1
公开(公告)日：2023-05-17
申请号：EP21838936.9
申请日：2021-07-07
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公开(公告)号：EP3998281A1
公开(公告)日：2022-05-18
申请号：EP21195070.4
申请日：2017-02-06
发明人： TAVERNIER, Jan , CAUWELS, Anje , KLEY, Nikolai , GERLO, Sarah
摘要： The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
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公开(公告)号：EP3371311A1
公开(公告)日：2018-09-12
申请号：EP16810454.5
申请日：2016-11-07
发明人： KLEY, Nikolai , TAVERNIER, Jan , HUYGHE, Leander , WUEEST, Thomas
IPC分类号： C12N15/62 , C07K14/525 , C07K14/505 , C07K14/52
CPC分类号： C07K14/525 , C07K14/505 , C07K14/52 , C07K2319/33 , C07K2319/75
摘要： The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
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