公开(公告)号：EP2331969A2

公开(公告)日：2011-06-15

申请号：EP09819705.6

申请日：2009-10-05

申请人： Morehouse School of Medicine

发明人： NEWMAN, Gale, W. ,  POWELL, Mike ,  DOHERTY, Akins ,  OBIALO, Chamberlain ,  MITCHELL-ALI, Claudette ,  BASHIR, Khalid ,  KHAN, Mafuz

IPC分类号： G01N33/68 ,  G01N33/493

CPC分类号： G01N33/56988 ,  G01N1/40 ,  G01N33/493 ,  G01N33/6893 ,  G01N2333/161 ,  G01N2333/162 ,  G01N2333/163 ,  G01N2800/347 ,  G01N2800/56

摘要： A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HFV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated nephropathy is also disclosed.

公开(公告)号：EP2240604A2

公开(公告)日：2010-10-20

申请号：EP09701723.0

申请日：2009-01-16

申请人： North Carolina State University

发明人： AGRIS, Paul, F.

IPC分类号： C12Q1/68 ,  C07K7/00

CPC分类号： G01N33/56988 ,  G01N2333/161 ,  G01N2333/162 ,  G01N2500/02

摘要： Host RNA/viral protein interaction as a target of intervention in the replication of viruses, e.g., the human immunodeficiency virus (HIV) are described. The target being upstream of the final replication product, and being crucial to the viral replication, is less likely to be genetically altered to drug resistance. Peptides that intervene in this RNA/viral protein interaction are also described, as well as compositions containing the same and methods of use thereof.

公开(公告)号：EP1613262A2

公开(公告)日：2006-01-11

申请号：EP02765887.1

申请日：2002-07-26

申请人： The University of Utah Research Foundation

发明人： SUNDQUIST, Wesley, I. ,  WANG, Hui ,  HILL, Christopher, P. ,  STEMMLER, Timothy, L. ,  DAVIS, Darrell, R. ,  ALAM, Steve

IPC分类号： A61K6/00

CPC分类号： C07K14/005 ,  C12N2740/16222 ,  G01N33/56988 ,  G01N2333/161 ,  G01N2500/02 ,  G01N2500/04

摘要： Disclosed are methods and compositions for assays related to particle formation of the HIV virus.

公开(公告)号：EP1401490A4

公开(公告)日：2005-09-21

申请号：EP02731876

申请日：2002-05-21

申请人： UNIV NEW YORK STATE RES FOUND ,  COHEN STANLEY N

发明人： COHEN S N ,  CARTER CAROL ,  GOFF ARTHUR ,  EHRLICH LORNA

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61P31/12 ,  A61P31/18 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/16 ,  C07K14/47 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  A61K39/21 ,  A01N43/04 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/64

CPC分类号： G01N33/502 ,  A61K38/1709 ,  C07K14/005 ,  C07K14/4702 ,  C07K2319/00 ,  C12N2740/16222 ,  G01N33/5008 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/16 ,  G01N2333/161 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.

公开(公告)号：EP1401490A1

公开(公告)日：2004-03-31

申请号：EP02731876.5

申请日：2002-05-21

申请人： THE RESEARCH FOUNDATION OFSTATE UNIVERSITY OF NEW YORK ,  Cohen, Stanley N.

发明人： COHEN, S.N.,Dept of Genetics School of Medicine ,  CARTER, Carol ,  GOFF, Arthur ,  EHRLICH, Lorna

IPC分类号： A61K39/21 ,  A01N43/04 ,  G01N33/53 ,  C12Q1/68 ,  C12N15/00 ,  C12N15/64 ,  C12N5/00 ,  C12N15/63

CPC分类号： G01N33/502 ,  A61K38/1709 ,  C07K14/005 ,  C07K14/4702 ,  C07K2319/00 ,  C12N2740/16222 ,  G01N33/5008 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/16 ,  G01N2333/161 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.

公开(公告)号：EP1141719A1

公开(公告)日：2001-10-10

申请号：EP99964735.7

申请日：1999-12-29

申请人： INSTITUT PASTEUR DE LILLE ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  Gras-Masse, Hélène

发明人： TRANCHAND-BUNEL, Denis ,  AURIAULT, Claude

IPC分类号： G01N33/569

CPC分类号： C07K14/005 ,  C12N2740/16222 ,  G01N33/56988 ,  G01N2333/161

摘要： The invention concerns a reagent for detecting and monitoring viral infections, caused by the human immunodeficiency virus (HIV) and its uses for detecting human immunodeficiency. Said reaction comprises a mixture consisting of (1) an antigenic peptide coded by the HIV pol gene comprising 60 amino acids, preferably between 20 and 40 amino acids; and (2) a mixture (called mixotope) of convergent combinatorial peptides, derived form said antigenic peptides.

公开(公告)号：EP2776463B1

公开(公告)日：2017-09-20

申请号：EP12847241.2

申请日：2012-11-07

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  LAUB, Leo, B. ,  KWONG, Peter ,  NABEL, Gary ,  MASCOLA, John, R. ,  ZHANG, Baoshan ,  RUDICELL, Rebecca, S. ,  GEORGIEV, Ivelin ,  YANG, Yongping ,  ZHU, Jiang ,  OFEK, Gilad

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18 ,  C12N15/13

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K49/0004 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1045 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/56988 ,  G01N2333/161

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

摘要翻译： 公开了单克隆中和抗体，其特异性结合HIV-1 gp41膜近端外部区域（MPER）。 还公开了包含特异性结合gp41的公开抗体，编码这些抗体的核酸，包含核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或诊断AIDS。 另外，所公开的抗体的广泛中和宽度使得它们理想地用于治疗HIV感染的受试者。 因此，公开了治疗和/或预防HIV感染的方法。

公开(公告)号：EP2783219A1

公开(公告)日：2014-10-01

申请号：EP12795253.9

申请日：2012-11-19

申请人： Bristol-Myers Squibb Company

发明人： KRYSTAL, Mark R. ,  HANNA, George

IPC分类号： G01N33/569

CPC分类号： G01N33/56988 ,  G01N2333/161 ,  G01N2333/162 ,  G01N2333/70514 ,  G01N2800/52

摘要： The present invention provides novel compositions and methods that can be used for determining the susceptibility of a virus to an attachment inhibitor. The present invention also provides methods for predicting whether an infected individual will respond to treatment with an attachment inhibitor, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects.

公开(公告)号：EP1957975A2

公开(公告)日：2008-08-20

申请号：EP06848507.7

申请日：2006-12-08

申请人： IRM, LLC

发明人： NGUYEN, Deborah ,  KUHEN, Kelli ,  CALDWELL, Jeremy

IPC分类号： G01N33/50

CPC分类号： C12Q1/6897 ,  C12Q1/18 ,  G01N33/56988 ,  G01N2333/161 ,  G01N2500/00

摘要： This invention provides novel HIV-interacting host factors. The invention also provides methods of using the HIV-interacting host factors to screen for compounds that inhibit HIV infection. The methods comprise first screening test compounds for modulators of an HIV-interacting host factor disclosed herein, and then further screening the identified modulating compounds for ability to inhibit HIV infection. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with HIV infection.

公开(公告)号：EP1401490B1

公开(公告)日：2008-07-16

申请号：EP02731876.5

申请日：2002-05-21

申请人： The Research Foundation of the State University of New York ,  Cohen, Stanley N.

发明人： COHEN, Stanley N., Dept. of Genetics School of Medicine ,  CARTER, Carol ,  GOFF, Arthur ,  EHRLICH, Lorna

IPC分类号： G01N33/50 ,  G01N33/569 ,  G01N33/68 ,  C07K14/16 ,  C07K14/47

CPC分类号： G01N33/502 ,  A61K38/1709 ,  C07K14/005 ,  C07K14/4702 ,  C07K2319/00 ,  C12N2740/16222 ,  G01N33/5008 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/16 ,  G01N2333/161 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.