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公开(公告)号：EP3981782A1
公开(公告)日：2022-04-13
申请号：EP21194967.2
申请日：2016-05-20
发明人： GE, Shengxiang , LI, Tingdong , JIA, Lianzhi , LI, Yijian , XUE, Miaoge , ZENG, Yuanjun , ZHANG, Jun , XIA, Ningshao , PAN, Huirong
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
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公开(公告)号：EP3805253A1
公开(公告)日：2021-04-14
申请号：EP19815471.8
申请日：2019-06-04
发明人： LI, Shaowei , WANG, Daning , WANG, Zhiping , LIU, Xinlin , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/11 , A61K39/12 , A61P35/00
摘要： The invention relates to a mutated HPV39 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV39 and HPV68, or HPV39, HPV68 and HPV70), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.
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公开(公告)号：EP3385274A1
公开(公告)日：2018-10-10
申请号：EP16870021.9
申请日：2016-12-02
发明人： LI, Shaowei , WANG, Daning , LIU, Xinlin , LI, Zhihai , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12P21/02 , A61K39/12 , A61P17/12
CPC分类号： A61K39/12 , C07K14/025 , C12P21/02
摘要： Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.
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公开(公告)号：EP3342866A1
公开(公告)日：2018-07-04
申请号：EP16838561.5
申请日：2016-08-24
发明人： ZHANG, Tianying , YUAN, Quan , GUO, Xueran , ZHANG, Ying , ZHAO, Qinjian , ZHANG, Jun , XIA, Ningshao
CPC分类号： A61K39/29 , A61K39/385 , C07K19/00 , C12N7/04 , C12N15/62
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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35.发明公开POLYPEPTIDES AND ANTIBODIES FOR TREATING HBV INFECTION AND RELATED DISEASES 审中-公开用于治疗HBV感染和相关疾病的多肽和抗体
公开(公告)号：EP3308798A2
公开(公告)日：2018-04-18
申请号：EP17203789.7
申请日：2013-06-06
发明人： YUAN, Quan , ZHANG, Tianying , LUO, Wenxin , CHEN, Yixin , ZHANG, Jun , XIA, Ningshao
IPC分类号： A61K39/12
摘要： The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositons for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.
摘要翻译： 本发明涉及用于治疗乙型肝炎病毒感染的表位肽（或其突变体），包含此类表位肽（或其突变体）和载体蛋白的重组蛋白，以及此类表位肽（或其突变体）和重组蛋白的用途。 本发明还涉及抗此类表位肽的抗体，产生所述抗体的细胞系及其用途。 此外，本发明涉及用于治疗或缓解与乙型肝炎病毒感染相关的一种或多种症状的疫苗或药物组合物，其分别包含根据本发明的重组蛋白或抗体。
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36.发明公开IN VITRO PREPARATION METHOD OF ROTAVIRUS DOUBLE-LAYER VIRUS-LIKE PARTICLES 审中-公开VITRO-VERFAHREN ZUR HERSTELLUNG VON ROTAVIRUS-DOPPELSCHICHTIGENVIRUSÄHNLICHENPARTIKELN
公开(公告)号：EP2899267A1
公开(公告)日：2015-07-29
申请号：EP13838213.0
申请日：2013-06-24
发明人： GE, Shengxiang , LI, Tingdong , GUO, Qingshun , XU, Feihai , ZHANG, Jun , XIA, Ningshao
CPC分类号： C12N7/00 , A61K38/162 , A61K39/00 , C12N7/04 , C12N2720/12322 , C12N2720/12323 , C12N2720/12333 , C12N2720/12334 , C12N2720/12352
摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
摘要翻译： 本发明涉及体外制备轮状病毒双层病毒样颗粒的方法。 该方法包括以下步骤：从裂解上清液中纯化轮状病毒VP6蛋白，以及体外组装由VP2蛋白和VP6蛋白组成的双层病毒样颗粒，其中蛋白质和病毒样颗粒可用于预防或 减少轮状病毒感染引起的临床症状。
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37.发明公开TRUNCATED HUMAN PAPILLOMAVIRUS TYPE 58 L1 PROTEIN 有权TRUNKIERTE L1-PROTEINE DES HUMANEN PAPILLOMAVIRUS TYP 58
公开(公告)号：EP2594579A1
公开(公告)日：2013-05-22
申请号：EP11806304.9
申请日：2011-07-15
发明人： LI, Shaowei , WEI, Minxi , KONG, Xianglin , WANG, Yingbin , ZHANG, Jun , XIA, Ningshao
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.
摘要翻译： 提供人类乳头瘤病毒58型的N-末端截短的L1蛋白，其编码序列及其制备方法和包含该蛋白质的病毒样颗粒。 还提供了蛋白质和病毒样颗粒在制备药物组合物或疫苗中的用途。 药物组合物或疫苗用于预防HPV感染和HPV感染引起的疾病。
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公开(公告)号：EP4086275A1
公开(公告)日：2022-11-09
申请号：EP20910955.2
申请日：2020-11-09
发明人： GE, Shengxiang , YU, Siyuan , YANG, Han , PAN, Haifeng , REN, Shuling , LI, Tingdong , GUO, Qingshun , XIONG, Junhui , ZHANG, Jun , XIA, Ningshao
摘要： A multimerization delivery system that can be used to deliver a cargo molecule intracellularly. The multimerization delivery system can achieve high-efficiency endocytosis of a cargo molecule and high-efficiency release thereof from an endocytic vesicle, significantly improving the cytoplasmic delivery efficiency of the cargo molecule. Once the cargo molecule is available in the cytoplasm, the cargo molecule can play any role related thereto. The multimerization delivery system provides an effective means for affecting the biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.
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公开(公告)号：EP3783100A1
公开(公告)日：2021-02-24
申请号：EP19788373.9
申请日：2019-04-15
发明人： CHENG, Tong , WANG, Wei , YE, Xiangzhong , FU, Wenkun , PAN, Dequan , ZHANG, Jun , XIA, Ningshao
摘要： Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.
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公开(公告)号：EP2154148B1
公开(公告)日：2016-06-22
申请号：EP08757380.4
申请日：2008-05-29
发明人： ZHANG, Jun , WANG, Jin , YANG, Chunyan , GU, Ying , LI, Shaowei , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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