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公开(公告)号：EP3656854A1
公开(公告)日：2020-05-27
申请号：EP18835927.7
申请日：2018-07-18
发明人： CHENG, Tong , WANG, Wei , WAN, Junkai , FU, Wenkun , YE, Xiangzhong , ZHANG, Jun , XIA, Ningshao
摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.
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公开(公告)号：EP3617317A1
公开(公告)日：2020-03-04
申请号：EP18754095.0
申请日：2018-02-05
发明人： ZHANG, Tianying , YUAN, Quan , GUO, Xueran , WEI, Minxi , KANG, Xiaozhen , ZHANG, Jun , XIA, Ningshao
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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公开(公告)号：EP3594328A1
公开(公告)日：2020-01-15
申请号：EP18764074.3
申请日：2018-02-28
发明人： HUANG, Chenghao , LUO, Yong , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： C12N7/00 , C12N15/869 , C12N5/10 , A61K35/763 , A61P35/00
摘要： The invention relates to the field of virology and tumor therapy. In particular, the present invention provides a recombinant herpes simplex virus (HSV) capable of specifically replicating at a high level in a tumor cell and effectively killing the tumor cell, but replicating at low levels in normal cells, thereby the recombinant herpes simplex virus of the present invention not only has high lethality against tumor cells, but also has significantly decreased side effects (especially neurotoxicity). Further, the present invention relates to a viral vector constructed based on the recombinant herpes simplex virus, a pharmaceutical composition comprising the recombinant herpes simplex virus or the viral vector, and the use of the recombinant herpes simplex virus or the viral vector. The recombinant herpes simplex virus of the present invention can be used to infect and kill tumor cells, and can be used for gene drug delivery into tumor cells for gene therapy.
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公开(公告)号：EP4186505A1
公开(公告)日：2023-05-31
申请号：EP21821809.7
申请日：2021-06-01
发明人： ZHANG, Tianying , CAO, Jiali , SHI, Tianshu , MA, Jian , WANG, Shaojuan , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： A61K31/415 , A61P31/20
摘要： The present application relates to the field of antiviral treatment of hepatitis B, and specifically relates to the use of a compound represented by formula I in treatment against HBV virus.
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公开(公告)号：EP2860188B1
公开(公告)日：2020-10-21
申请号：EP13804161.1
申请日：2013-06-06
发明人： YUAN, Quan , ZHANG, Tianying , LUO, Wenxin , CHEN, Yixin , ZHANG, Jun , XIA, Ningshao
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公开(公告)号：EP3360896A1
公开(公告)日：2018-08-15
申请号：EP16853117.6
申请日：2016-10-09
发明人： LUO, Wenxin , ZHOU, Bing , ZHANG, Juan , YUAN, Quan , ZHANG, Tianying , ZHANG, Jun , XIA, Ningshao
CPC分类号： A61K39/395 , C07K16/10 , C12N5/10 , C12N15/63
摘要： The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.
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公开(公告)号：EP3783100A1
公开(公告)日：2021-02-24
申请号：EP19788373.9
申请日：2019-04-15
发明人： CHENG, Tong , WANG, Wei , YE, Xiangzhong , FU, Wenkun , PAN, Dequan , ZHANG, Jun , XIA, Ningshao
摘要： Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.
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公开(公告)号：EP4174181A1
公开(公告)日：2023-05-03
申请号：EP21829053.4
申请日：2021-06-24
发明人： YUAN, Quan , CAO, Jiali , ZHANG, Yali , WANG, Mingfeng , MA, Jian , ZHANG, Tianying , ZHANG, Jun , XIA, Ningshao
摘要： The present invention belongs to the field of virology, in particular to the field of hepatitis B virus treatment. Provided are a model and a method for screening HBV cccDNA inhibitors. According to the screening model and the method, the detection of a split luciferase is used as an alternative index of HBV cccDNA detection, and a cccDNA-targeted drug can be screened in high throughput.
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公开(公告)号：EP3308798B1
公开(公告)日：2020-09-09
申请号：EP17203789.7
申请日：2013-06-06
发明人： YUAN, Quan , ZHANG, Tianying , LUO, Wenxin , CHEN, Yixin , ZHANG, Jun , XIA, Ningshao
IPC分类号： A61K39/12
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10.发明公开MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USES THEREOF 有权AN DASHÄMAGGLUTININVOM AVIAN INFLUENZA VIRUS SUBTYPE H5 BINDENDE MONOKLONALEANTIKÖRPERUND ANWENDUNGEN DAVON
公开(公告)号：EP2174957A1
公开(公告)日：2010-04-14
申请号：EP08772961.2
申请日：2008-06-16
发明人： CHEN, Yixin , LUO, Wenxin , ZHANG, Jun , XIA, Ningshao , GUAN, Yi , CHEN, Honglin
IPC分类号： C07K16/18 , C07K16/46 , C12N5/12 , C12N15/13 , C12N15/63 , G01N33/53 , G01N33/569 , A61K39/395 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61P31/16 , C07K14/11
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： The present invention provides monoclonal antibodies that bind specifically to H5 subtype avian influenza virus hemagglutinin (HA) proteins, and can block the binding activity of at least 50% of the known monoclonal antibodies to the H5 subtype avian influenza virus hemagglutinin (HA) protein. The monoclonal antibodies can be used for the detection, diagnosis, prevention, and treatment of avian influenza viruses, especially the H5 subtype of avian influenza viruses. The present invention also provides the related hybridoma cell lines, isolated nucleic acid molecules and short peptides, as well as medical composition and medical diagnostic equipment and kit containing the monoclonal antibody.
摘要翻译： 本发明提供了与H5亚型禽流感病毒血凝素（HA）蛋白特异性结合的单克隆抗体，并且可以阻断至少50％的已知单克隆抗体与H5亚型禽流感病毒血凝素（HA）蛋白的结合活性。 单克隆抗体可用于检测，诊断，预防和治疗禽流感病毒，特别是禽流感病毒的H5亚型。 本发明还提供了相关的杂交瘤细胞系，分离的核酸分子和短肽，以及包含单克隆抗体的医药组合物和医学诊断设备和试剂盒。
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