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公开(公告)号：EP4086275A1
公开(公告)日：2022-11-09
申请号：EP20910955.2
申请日：2020-11-09
发明人： GE, Shengxiang , YU, Siyuan , YANG, Han , PAN, Haifeng , REN, Shuling , LI, Tingdong , GUO, Qingshun , XIONG, Junhui , ZHANG, Jun , XIA, Ningshao
摘要： A multimerization delivery system that can be used to deliver a cargo molecule intracellularly. The multimerization delivery system can achieve high-efficiency endocytosis of a cargo molecule and high-efficiency release thereof from an endocytic vesicle, significantly improving the cytoplasmic delivery efficiency of the cargo molecule. Once the cargo molecule is available in the cytoplasm, the cargo molecule can play any role related thereto. The multimerization delivery system provides an effective means for affecting the biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.
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公开(公告)号：EP4006057A1
公开(公告)日：2022-06-01
申请号：EP20837897.6
申请日：2020-07-10
发明人： GE, Shengxiang , YU, Siyuan , YANG, Han , PAN, Haifeng , REN, Shuling , LI, Tingdong , GUO, Qingshun , XIONG, Junhui , ZHANG, Jun , XIA, Ningshao
摘要： A fusion protein and a complex containing same, capable of being used for the intracellular delivery of cargo molecules. The fusion protein and complex can implement the efficient release of cargo molecules from endocytic vesicles, thereby significantly improving the cytoplasmic delivery efficiency of the cargo molecules. One cargo molecules can be obtained in cytoplasms, they can exert any function related thereto. The fusion protein and complex provide effective means for affecting biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.
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公开(公告)号：EP4092050A1
公开(公告)日：2022-11-23
申请号：EP21741247.7
申请日：2021-01-18
发明人： CHEN, Zimin , XIONG, Junhui , LIU, Jiaqi , WANG, Shaojuan , GE, Shengxiang , YUAN, Quan , SONG, Liuwei , SUN, Xudong
IPC分类号： C07K16/18
摘要： In the field of Hepatitis B virus (HBV) detection, disclosed are a method for detecting HBcAg by means of using a double antibody sandwich method, and an antibody and kit for detecting HBcAg; also included is a monoclonal antibody that can be used in the immunological detection of HBcAg in a tissue or cell sample.
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公开(公告)号：EP3812771A1
公开(公告)日：2021-04-28
申请号：EP19823488.2
申请日：2019-05-29
发明人： CHEN, Zimin , XIONG, Junhui , XU, Weiling , WENG, Zuxing , WANG, Long , ZHENG, Xiaohong , SUN, Xudong , GE, Shengxiang
IPC分类号： G01N33/68
摘要： The invention provides a kit for full-range detection of C-reactive protein based on chemiluminescence immunoassay and a method for full-range detection of C-reactive protein. The kit comprises an R1 reagent, an M reagent, an R2 reagent, a pre-excitation solution and an excitation solution. The R1 reagent, that is a sample treatment solution, is a 0.5M citric acid solution (pH 3.0-3.5, which is adjusted by disodium hydrogen phosphate dodecahydrate). The present invention also provides a kit for full-range detection of C-reactive protein, which comprises a flat-bottomed plate-type chemiluminescence plate coated with a first antibody, a sample treatment solution, a second antibody labeled with horseradish peroxidase (HRP) or alkaline phosphatase (AP), a color developing solution. The invention also provides a method for full-range detection of C-reactive protein using the kit. Both the first antibody and the second antibody are monoclonal antibodies that can specifically react with C-reactive protein.
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公开(公告)号：EP3885363A1
公开(公告)日：2021-09-29
申请号：EP19888178.1
申请日：2019-11-06
发明人： XIONG, Junhui , CHEN, Zimin , XU, Weiling , WANG, Long , KE, Qishen , LI, Lihua , SONG, Liuwei , SUN, Xudong , GE, Shengxiang
IPC分类号： C07K16/26 , C12N5/20 , G01N33/74 , G01N33/577
摘要： The present invention belongs to the field of biomedical laboratory science, and provides a specific antibody for AMH and uses thereof.
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