公开(公告)号：EP2684609A1

公开(公告)日：2014-01-15

申请号：EP12175582.1

申请日：2012-07-09

申请人： Biocartis SA

发明人： Van Meerbergen, Bart ,  Penterman, Roel ,  Vergauwe, Nicolas

IPC分类号： B01L7/00 ,  B01L3/00

CPC分类号： B01L7/52 ,  B01L3/505 ,  B01L2200/0684 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2400/0481

摘要： System for performing biological analysis comprising:
- a cartridge (20) having a deformable chamber (24) suitable for containing a liquid to be analyzed;
- a heater (15) having a heating face arranged to heat the liquid contained in the deformable chamber (24);

characterized in that the heating face of the heater (15) is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber (24) in order to compensate an increase of pressure in the deformable chamber (24) during the heating of said liquid by said heater.

摘要翻译： 用于执行生物分析的系统，包括： - 具有适于容纳待分析液体的可变形室（24）的盒（20） - 加热器（15），其具有布置成加热容纳在可变形室（24）中的液体的加热面; 其特征在于，加热器（15）的加热面可以从第一位置移动到与第一位置不同的至少第二位置，以允许增加所述可变形室（24）的体积以补偿增加 在所述加热器加热所述液体期间在可变形室（24）中的压力。

公开(公告)号：EP2684605A1

公开(公告)日：2014-01-15

申请号：EP12175903.9

申请日：2012-07-11

申请人： Biocartis SA

发明人： Tornay, Raphaël ,  Demierre, Nicolas ,  Coulot, Laurent

IPC分类号： B01L3/00 ,  G01N33/50

CPC分类号： B01L3/502761 ,  B01L3/502715 ,  B01L3/50273 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2300/0858 ,  Y10T436/2575

摘要： The present invention relates to a method for injecting microparticles (6) into a microfluidic channel (13) by means of injecting means, said microfluidic channel opening out on a sidewall (15) of an inlet well (14), the method comprising the steps of:
a) positioning the injecting means tip above said sidewall and at a predetermined distance (d) therefrom, and
b) injecting the microparticles into said inlet well so that they come into contact with said sidewall during injection, the sidewall being tilted so that at least a portion of the microparticles included in the injected liquid sample slides on the sidewall and enters the microfluidic channel.

摘要翻译： 本发明涉及一种通过注入装置将微粒（6）注入微流体通道（13）的方法，所述微流体通道在入口井（14）的侧壁（15）上开口，该方法包括步骤 ：a）将注射装置尖端定位在所述侧壁上方并与其预定的距离（d），以及b）将微粒注入所述入口井，使得它们在注射期间与所述侧壁接触，所述侧壁倾斜，使得 被注入的液体样品中包含的微粒的至少一部分在侧壁上滑动并进入微流体通道。

公开(公告)号：EP2673086A1

公开(公告)日：2013-12-18

申请号：EP12703428.8

申请日：2012-02-06

申请人： Biocartis SA

发明人： DEMIERRE, Nicolas

IPC分类号： B01L3/00

CPC分类号： G01N21/6486 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00558 ,  B01J2219/0056 ,  B01J2219/00576 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0832 ,  G01N33/54313

摘要： The present invention relates to an encoded microcarrier (2) comprising a readable code attached to it for identification, said encoded microcarrier (2) comprising a body (3) having at least a detection surface (6) to detect a chemical and/or biological reaction, the microcarrier further comprising at least a spacing element (9) projecting from the body (3) and shaped to ensure that, when the encoded microcarrier (2) is laid on a flat plane with the detection surface (6) facing said flat plane, a gap exists between said flat plane and the detection surface (6). The invention also relates to an assay device designed to use a plurality of said encoded microcarriers (2) to perform assays. The invention relates finally to a method for monitoring a chemical or biological reaction.

公开(公告)号：EP2577252A2

公开(公告)日：2013-04-10

申请号：EP11723221.5

申请日：2011-05-27

申请人： Biocartis SA

发明人： PIERIK, Anke ,  OFFERMANS, Paul ,  MEIJERING, Bernadet ,  SILLEKENS, Peter ,  STAPERT, Henk

IPC分类号： G01N1/30 ,  C12Q1/68

CPC分类号： C09K15/28 ,  C09K15/20 ,  C12Q1/6806 ,  C12Q1/686 ,  Y10T428/13 ,  C12Q2527/125

摘要： The present invention relates to the field of improving and stabilizing concentrated solutions and in particular to improving and stabilizing concentrated solutions for the extraction of nucleic acids from sample material. Thus, the present invention, further, relates to the field of molecular biology. The present invention describes the use of betaines for stabilizing organic salts or chaotropic agents in solution which is particularly useful in cases where organic salts or chaotropic agents are present at high concentration such as for example chaotropic agents in buffers for the extraction of nucleic acids from sample material. The present invention describes the corresponding buffers and further relates to processes for the extraction of nucleic acids from sample material as well as processes for the analysis of sample material. Moreover, the present invention relates to kits and cartridges comprising at least one container with the corresponding buffer.

公开(公告)号：EP2208075B1

公开(公告)日：2013-02-20

申请号：EP08845837.7

申请日：2008-10-22

申请人： Biocartis SA

发明人： PIERIK, Anke ,  DIJKSMAN, Johan, F.

IPC分类号： B01L99/00

CPC分类号： C12Q1/6888 ,  B01L7/52

公开(公告)号：EP2419743A1

公开(公告)日：2012-02-22

申请号：EP10713295.3

申请日：2010-04-09

申请人： Biocartis SA

发明人： KOLESNYCHENKO, Aleksey ,  DE VRIES, Jorrit, E. ,  VERSLEEGERS, Jozef, C., M. ,  DE JONG, Michiel ,  HADDEMAN, Theodoor, B., J. ,  STROUCKEN, Louis

IPC分类号： G01N35/02 ,  G01N21/25 ,  G01N21/64

摘要： An optical detection system for monitoring real-time PCR reactions in a plurality of sample chambers with a plurality of optical units is provided. Due to a relative movement, the optical units are relative to the sample chambers, color multiplexing and space multiplexing are combined for optically detecting pathogens in a sample during the process of the PCR and delivering a quantitative result.

公开(公告)号：EP2419220A1

公开(公告)日：2012-02-22

申请号：EP10713296.1

申请日：2010-04-09

申请人： Biocartis SA

发明人： DE GIER, Ronald ,  VERSLEEGERS, Jozef, C., M.

IPC分类号： B01L9/00

CPC分类号： B01L9/52 ,  B01L7/52 ,  B01L2200/141 ,  B01L2200/18 ,  B01L2300/041

摘要： An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.

摘要翻译： 提供了一种用于进行生物分析处理和分析的装置，生物分析反应装置及其盒。 所述筒包含壳体和用于存储生物样品的平台中的至少一个样品室，所述生物分析反应装置可以处理和分析。 平台可移动地连接到壳体，使得平台可在收起位置之间移动，收集位置中样本室被壳体保护，并且延伸位置，样本室在壳体的外部。 生物分析反应装置包括用于在收起位置和延伸位置之间移动平台的致动装置。

公开(公告)号：EP2409767A1

公开(公告)日：2012-01-25

申请号：EP11005261.0

申请日：2006-06-16

申请人： Biocartis SA

发明人： Van Haag, Chris ,  Jongerius, Michiel ,  Schaefer, Danny G.A. ,  Van den Bijgaart, Adrianus ,  De Gier, Ronald ,  De Jong, Michiel ,  Pross, Gerhard ,  Bacher, Johannes ,  Boos, Andreas ,  Luedke, Gerd ,  Seher, Jens-Peter

IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N21/76 ,  G01N35/00 ,  G01N33/487 ,  G01N21/64 ,  C12Q1/68

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/545 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/02 ,  B01L2300/087 ,  B01L2300/1805 ,  G01N21/6428 ,  G01N35/00069 ,  G01N2035/00158

摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.

摘要翻译： 公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。 墨盒包括通用部件和可以连接到通用部件的一个或多个单独的应用特定部件。 还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。 该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

公开(公告)号：EP2367633A1

公开(公告)日：2011-09-28

申请号：EP09795681.7

申请日：2009-12-23

申请人： Biocartis SA

发明人： DEMIERRE, Nicolas ,  NADER, Donzel ,  GIL, José ,  RENAUD, Philippe

IPC分类号： B01L3/00 ,  B01J19/00 ,  G01N33/543

CPC分类号： G01N33/54373 ,  B01J2219/005 ,  B01J2219/00556 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0487

摘要： The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the longitudinal movement of the microcarriers 2 is restricted and wherein the microcarriers 2 have a shape in relation to the geometry of the microchannel 1 such that at least two can stand side by side in the microchannel 1 without touching each other and without touching the perimeter of the microchannel 1 and are preferably observable in the reaction chamber. Moreover, the invention provides a method for performing multiplexed assay based on microcarriers 2 that improves mass transfer, simplifies the preparation and the execution of the assay and facilitates readout of biological reactions and identity of microcarriers 2.

公开(公告)号：EP2235207A1

公开(公告)日：2010-10-06

申请号：EP08861093.6

申请日：2008-12-16

申请人： Biocartis SA

发明人： VOSSENAAR, Erik, R. ,  KLUNDER, Derk, J., W. ,  STAPERT, Hendrik, R. ,  VAN HOUTEN, Henk ,  VAN GEMEN, Bob ,  VAN DIJK, Erik, M., H., P.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6818 ,  C12Q1/6851 ,  C12Q2525/301 ,  C12Q2565/1015 ,  C12Q2565/549 ,  C12Q2561/113

摘要： The present invention relates to a process for conducting real-time PCR, and to a device for conducting the method of the present invention. The invention is especially suited for the simultaneous identification and quantification of nucleic acids present in a sample, e.g. a biological sample. Further, this invention describes a method for simultaneous quantitative analysis of multiple nucleic acid sequences in a single compartment by using an integrated nucleic acid microarray combined with a highly surface-specific readout device. The invention relates to a device wherein a surface which is either part of the chamber surface or a surface that is created in the reaction chamber, such as bead surface, is coated with capture probes and in the same chamber, a PCR reaction takes place.