公开(公告)号：EP2688575B1

公开(公告)日：2016-03-23

申请号：EP12760816.4

申请日：2012-03-26

Applicant: University of South Florida

Inventor： ZAWOROTKO, Michael J. ,  SHYTLE, Roland D. ,  ONG, Tien Teng ,  KAVURU, Padmini ,  CANTWELL, Ryan N. ,  NGUYEN, Tranhha ,  SMITH, Adam John

IPC: A61K33/14 ,  A61K33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K45/06 ,  A61K33/00 ,  A61K47/18 ,  A61K47/22 ,  A61K9/14

CPC classification number: A61K47/183 ,  A61K9/145 ,  A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  A61K47/186 ,  A61K47/22 ,  A61K2300/00

公开(公告)号：EP2978434A1

公开(公告)日：2016-02-03

申请号：EP13879812.9

申请日：2013-05-30

Applicant: Pharmacaribe LLC

Inventor： WARNER, William Randolph ,  GUTMANN, Werner

IPC: A61K33/14 ,  A61K9/08 ,  A61P11/00

CPC classification number: A61K9/08 ,  A61K9/0073 ,  A61K33/14 ,  A61M16/14

Abstract: Compositions, formulations and methods bio-balance the pH of sterile, sodium chloride inhalation and pulmonary irrigation solutions, such that the solutions are bio-similar to the homeostatic pH state of the Human Airway Surface Liquid (ASL) at 7.4. These solutions are sterile, non-pyrogenic, additive and preservative free, and provided in sterile unit-of-use, blow-fill-seal vials. These solutions are intended for use in the induction of sputum production where sputum production is indicated, such as with Cystic Fibrosis patients and Bronchoalveolar lavage procedures. The solutions can be provided in concentrations from about 1.0 to about 10% sodium chloride in USP / Sterile water. The sodium chloride solutions are homogenous mixtures (complete solutions) that include sterile water, sodium chloride, and sodium bicarbonate as a buffer. The solutions are provided in saline concentrations from 0.045% to 10%, for example, concentrations of 0.9%, 3%, 3.5%, 6%, 7% with a pH of 7.4.

公开(公告)号：EP2926835A1

公开(公告)日：2015-10-07

申请号：EP12889157.9

申请日：2012-11-27

Applicant: Terumo Kabushiki Kaisha

Inventor： USAMI Hirokazu ,  KOYAMA Yoshihiko ,  NISHITANI Hiroshi ,  ARIIZUMI Tsuyoshi

IPC: A61K47/36 ,  A61K9/08 ,  A61K31/718 ,  A61K47/02 ,  A61K47/12 ,  A61M1/14 ,  A61M1/28

CPC classification number: A61K33/14 ,  A61J1/10 ,  A61J1/202 ,  A61J1/2093 ,  A61K31/718 ,  A61M1/287 ,  A61K2300/00

Abstract: The present invention is a sterile peritoneal dialysis fluid, including an acidic first liquid containing 60.0 to 94.0 g/L of icodextrin and 0 to 2.34 g/L of sodium chloride, and an alkaline second liquid containing an alkaline pH regulator, in which the first liquid after sterilization has a pH of 5.0 to 5.5, the second liquid after sterilization has a pH of 6.5 to 7.5, and a mixture of the first liquid and the second liquid after sterilization has a pH of 6.0 to 7.5. The present invention can provide a peritoneal dialysis fluid containing icodextrin, in which the stability of icodextrin during the heat sterilization and the subsequent storage can be improved to the maximum, and the pH of the peritoneal dialysis fluid is close to the physiological range.

Abstract translation: 本发明是一种无菌腹膜透析液，其包含含有60.0〜94.0g / L的高粘蛋白和0〜2.34g / L氯化钠的酸性第一液体，以及含有碱性pH调节剂的碱性第二液体，其中， 灭菌后的液体的pH为5.0〜5.5，灭菌后的第二液体的pH为6.5〜7.5，灭菌后的第一液体和第二液体的混合物的pH为6.0〜7.5。 本发明可以提供含有icodextrin的腹膜透析液，其中在加热灭菌和随后的储存期间，icodextrin的稳定性可以最大程度地提高，并且腹膜透析液的pH接近于生理范围。

公开(公告)号：EP1982694B1

公开(公告)日：2015-08-19

申请号：EP07425234.7

申请日：2007-04-20

Applicant: D.M.G. Italia Srl

Inventor： Mercuri, Luigi

IPC: A61K8/00 ,  A61K47/06 ,  A61K31/06 ,  A61K9/06 ,  A61K47/44

CPC classification number: A61K31/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K33/00 ,  A61K33/06 ,  A61K33/14 ,  A61K47/06 ,  A61K47/10 ,  A61K47/44

公开(公告)号：EP1948205B1

公开(公告)日：2015-06-24

申请号：EP06837587.2

申请日：2006-11-14

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： TOLWANI, Ashita ,  SPEER, Rajesh ,  STOFAN, Brenda

IPC: A61K33/00 ,  A61K31/194

CPC classification number: A61K31/19 ,  A61K33/00 ,  A61K33/14 ,  A61K2300/00

公开(公告)号：EP2398444A4

公开(公告)日：2015-06-17

申请号：EP10743996

申请日：2010-02-17

Applicant: SEA QIQ AS

Inventor： ERITZLAND RUNE ,  MOLNES HARALD

IPC: A61K8/00 ,  A61K8/19 ,  A61K33/08 ,  A61Q11/00 ,  A61Q19/00 ,  C01F5/14

CPC classification number: A61Q19/00 ,  A61K8/19 ,  A61K33/08 ,  A61K33/14 ,  A61K2800/592 ,  A61K2800/75 ,  A61K2300/00

公开(公告)号：EP2875818A1

公开(公告)日：2015-05-27

申请号：EP14306580.3

申请日：2014-10-08

Applicant: Air Liquide Santé (International)

Inventor： Ellenberg, Eytan

IPC: A61K33/00 ,  A61P25/06

CPC classification number: A61M16/101 ,  A61K31/19 ,  A61K33/14 ,  A61K45/06 ,  A61M16/0078 ,  A61M16/0622 ,  A61M16/205 ,  A61M2202/0208 ,  A61K2300/00

Abstract: L'invention concerne une composition gazeuse inhalable contenant de l'oxygène (O 2 ) en une proportion supérieure à 50% en volume, destinée à traiter, à minimiser ou à prévenir une crise de migraine chronique chez un malade, ladite composition étant produite sur site, c'est-à-dire au domicile du malade, par un dispositif de production d'oxygène conçu pour produire un flux de gaz contenant plus de 50% d'oxygène à partir d'air.

公开(公告)号：EP2152304A4

公开(公告)日：2015-03-25

申请号：EP08747554

申请日：2008-05-02

Applicant: UNIV MICHIGAN

Inventor： BAKER JAMES R JR ,  RATHINAVELU SIVAPRAKASH ,  MAKIDON PAUL E ,  LIPUMA JOHN J ,  NIGAVEKAR SHRADDHA

IPC: A61K39/12 ,  A23L29/00 ,  A61K9/00 ,  A61K9/107 ,  A61K31/198 ,  A61K31/22 ,  A61K31/337 ,  A61K31/573 ,  A61K31/7048 ,  A61K33/14 ,  A61K35/00 ,  A61K36/00 ,  A61K45/06

CPC classification number: A61K31/198 ,  A01N25/04 ,  A23L29/10 ,  A23L33/135 ,  A23V2002/00 ,  A61K6/0008 ,  A61K9/0078 ,  A61K9/1075 ,  A61K31/22 ,  A61K31/337 ,  A61K31/573 ,  A61K31/7048 ,  A61K33/14 ,  A61K45/06 ,  A61K47/32 ,  B82Y5/00 ,  A23V2200/25

Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

Abstract translation: 本发明涉及治疗肺部感染的方法和组合物。 特别地，本发明提供纳米乳液组合物及其使用方法来处理与生物膜相关的细菌（例如在肺部感染中发现）。 除了别的以外，本发明的组合物和方法可用于临床（例如治疗和预防性药物），工业和研究应用。

公开(公告)号：EP2819691A1

公开(公告)日：2015-01-07

申请号：EP13710621.7

申请日：2013-03-01

Applicant: Erasmus University Medical Center Rotterdam

Inventor： MAHMOUDI, Tokameh

IPC: A61K38/17 ,  A61K31/15 ,  A61K33/20 ,  G01N33/50 ,  A61P31/18

CPC classification number: A61K33/14 ,  A61K31/185 ,  A61K31/404 ,  A61K33/00 ,  A61K38/1709 ,  C12Q1/18 ,  G01N2333/16 ,  G01N2333/475 ,  G01N2333/70514 ,  A61K2300/00

Abstract: The present invention relates to a method for increasing retrovirus transcription in an infected eukaryotic cell, comprising increasing Wnt pathway signaling in said cell such that transcription of said retrovirus is increased. Also, the present invention relates to a method of treating a subject infected with a retrovirus, said method comprising administering to said subject an activator of the Wnt pathway in an amount that increased Wnt pathway signaling in resting memory CD4+ T cells of said subject such that the retroviral long terminal repeat (LTR) in said cells is activated or de-repressed.

公开(公告)号：EP2647397B1

公开(公告)日：2014-10-08

申请号：EP13001560.5

申请日：2013-03-26

Applicant: Völker, Manfred

Inventor： Völker, Manfred

IPC: A61M1/16 ,  A61M1/28 ,  A61K45/06 ,  A61J1/20 ,  A61K9/10 ,  A61K31/7004 ,  A61K33/14

CPC classification number: A61K31/19 ,  A61K31/7004 ,  A61K33/14 ,  A61K45/06 ,  A61M1/1654 ,  A61K2300/00