公开(公告)号：EP2726852A1

公开(公告)日：2014-05-07

申请号：EP12740219.6

申请日：2012-06-25

Applicant: Koninklijke Philips N.V.

Inventor： NEIJZEN, Jacobus Hermanus Maria ,  DITTMER, Wendy Uyen ,  OVSYANKO, Mikhail Mikhaylovich

IPC: G01N21/55 ,  G01N33/543 ,  G01N21/03 ,  G01N21/31

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1') is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2') are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2') are detected by a single image sensor (155).

公开(公告)号：EP1630545B1

公开(公告)日：2013-01-02

申请号：EP05356136.1

申请日：2005-08-12

Applicant: SYSTEM INSTRUMENTS CO., LTD.

Inventor： Takahashi, Hiromi

IPC: G01N21/55

CPC classification number: G01N21/552 ,  G01N2201/066 ,  G01N2201/08

公开(公告)号：EP1564541B1

公开(公告)日：2010-06-02

申请号：EP05010332.4

申请日：1999-11-19

Applicant: Waters Technologies Corporation

Inventor： Gilby, Anthony C.

IPC: G01N21/00 ,  G01N1/10 ,  G01J5/02 ,  G01N21/31 ,  G01N21/03

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/31 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2030/625 ,  G01N2030/746 ,  G01N2201/066

公开(公告)号：EP1630545A1

公开(公告)日：2006-03-01

申请号：EP05356136.1

申请日：2005-08-12

Applicant: SYSTEM INSTRUMENTS CO., LTD.

Inventor： Takahashi, Hiromi

IPC: G01N21/55

CPC classification number: G01N21/552 ,  G01N2201/066 ,  G01N2201/08

Abstract: The device for measuring an optical absorption characteristic of a sample according to the present invention comprising a light source, a optical wave-guide (1) having light input surface(s) (2a) and light output surface(s) (2b) that are opposite to each other, and a light reflecting surface (3) on which a sample (4) to be measured is disposed, through which the light passes and is reflected by a total reflection on the sample (4), one or more light transmitting means arranged between the light output surface (2b) of the optical wave-guide (1) and the light input surface (2a) of the optical wave-guide (1) so that the light is again entered into the optical wave-guide (1), and a processing device which receives the light re-exited from the optical wave-guide (1) through the output surface (2b) and detects the optical absorption characteristics of the sample (4) on the basis of the light received, whereby the light which passes through the optical wave-guide (1) is conducted to the optical wave-guide (1) again, the light is again entered the optical wave-guide (1), and the light is again reflected on the sample.

Abstract translation: 用于样品雅丁的光吸收特性的测量，本发明的包括光源，光学波导（1），其具有光输入表面（或多个）（2a）和光输出表面（S）（2b）中做了设备 是彼此相反的，并且反射表面的光（3），其上（4）将被测量的样品被设置，通过该光通过，并且通过对样品（4），一个或多个光的全反射 光输出表面之间设置传输装置（2b）的光波导（1）所以没有的光学波导（1）和该光输入表面（2a）的光再次输入到光波导 （1），以及一个接收处理装置的光重新退出通过输出表面从所述光波导（1）（2b）和检测的光的接收的基础上，在样品（4）的光学吸收特性 ，由此它通过光波导传送的光（1）被引导到所述光学 人波导（1）再次，该光再次进入光学波导（1），并且该光被再次反射在样品上。

公开(公告)号：EP1564541A2

公开(公告)日：2005-08-17

申请号：EP05010332.4

申请日：1999-11-19

Applicant: Waters Investments Limited

Inventor： Gilby, Anthony C.

IPC: G01N21/00 ,  G01N1/10 ,  G01J5/02 ,  G01N21/31 ,  G01N21/03

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/31 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2030/625 ,  G01N2030/746 ,  G01N2201/066

Abstract: A flow cell (16) for absorbance detection with at least two different optical pathlengths (30, 32). It increases the range of analyte concentrations which can be measured compared with a conventional single path flow cell. Light from two paths (30, 32) is combined onto the same photodetector (20). Calibration with known samples allows analyte concentrations to be measured. The dual or multi-pathlength flow cell may be used in equipment designed for single path flow cells.

Abstract translation: 一种用于利用至少两个不同光程长度（30,32）进行吸光度检测的流动池（16）。 与传统的单路径流动池相比，它可以增加可测量的分析物浓度范围。 来自两个路径（30,32）的光被组合到相同的光电检测器（20）上。 用已知样品进行校准可以测量分析物浓度。 双通道或多通道流动池可用于为单路径流动池设计的设备。

公开(公告)号：EP1141675B1

公开(公告)日：2005-07-27

申请号：EP99962798.7

申请日：1999-11-19

Applicant: Waters Investments Limited

Inventor： GILBY, Anthony, C.

IPC: G01N21/00 ,  G01N1/10 ,  G01J5/02 ,  G01N21/31 ,  G01N21/03

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/31 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2030/625 ,  G01N2030/746 ,  G01N2201/066

公开(公告)号：EP0567230A3

公开(公告)日：1995-04-26

申请号：EP93302291.5

申请日：1993-03-25

Applicant: Becton Dickinson and Company

Inventor： Berndt, Klaus W.

IPC: C12M1/34 ,  G01N21/35

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N21/3504 ,  G01N2021/5969 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The C0 2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 µm, which is the C0 2 absorption characteristic wavelength. The determination of the absolute C0 2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

公开(公告)号：EP0145877A2

公开(公告)日：1985-06-26

申请号：EP84112134.6

申请日：1984-10-10

Applicant: Hartmann & Braun Aktiengesellschaft

Inventor： Schaefer, Werner, Dr. ,  Zöchbauer, Michael ,  Medebach, Helmut ,  Fabinski, Walter

IPC: G01N21/31 ,  G01N21/85

CPC classification number: G01N21/31 ,  G01J3/2803 ,  G01N21/15 ,  G01N21/255 ,  G01N21/314 ,  G01N21/8507 ,  G01N2021/154 ,  G01N2021/3181 ,  G01N2201/066 ,  G01N2201/08

Abstract: Fotometer zur kontinuierlichen Analyse eines Mediums (Gas oder Flüssigkeit) unter Verwendung von das Medium durchlaufendem Licht mit Wellenlängen, die von den einzelnen Komponenten des Mediums absorbiert werden, bei dem entweder der Lichtstrahlweg im zu analysierenden Medium periodisch auf zwei definierte Längen eingestellt wird, oder bei Ausbildung des Fotometers mit zwei festen Absorptionsstrecken unterschiedlicher Längen alternierend Licht zweier Strahlungsquellen unterschiedlicher Wellenlängen jeweils gleichzeitig über beide Absorptionsstrecken geleitet wird. Die zwei parallelen Lichtstrahlen können hierbei unter Einschaltung eines im zu analysierenden Medium angeordneten Prismas mit reflektierenden Kathoden erzeugt werden.

Abstract translation: 1.一种用于通过在经过供氧的氧化皮焊炬的扫描下移动被检查的表面来检测和记录热半成品铁或钢产品中的地下缺陷的方法，其特征在于，逐渐进行所述剥皮以使得所述金属表面被去除以暴露 底层金属，并且由相机检测到地下缺陷的视觉指示，并记录在远程位置，以便后续修复地下缺陷。

公开(公告)号：EP3394616A1

公开(公告)日：2018-10-31

申请号：EP16825752.5

申请日：2016-12-22

Applicant: Koninklijke Philips N.V.

Inventor： LARSEN, Niels, Agersnap

IPC: G01N33/49 ,  G01N21/59 ,  B01L3/00

CPC classification number: G01N33/49 ,  B01L3/502707 ,  B01L2200/148 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N21/0303 ,  G01N2021/0378 ,  G01N2021/0392 ,  G01N2201/066

Abstract: The invention relates to a method of determining a concentration of a substance in a cell suspension, said method comprising the following steps: - determining the concentration of the substance by: - using the results of absorption measurements performed at n local sample volumes contained at different average chamber heights of a chamber arrangement comprising the cell suspension and local substance concentration in said respective local sample volumes determined based on said respective absorption measurements; - using a substance concentration model comprising local substance concentration as a function of chamber height, and - determining the substance concentration as the infinite chamber height substance concentration using said substance concentration model and the determined local substance concentrations, wherein n is at least 2, such as at least 3, such as at least 4, wherein, optionally, the cell suspension is whole blood and the substance is Hb and wherein the method further comprises determining cRBC based on the determined Hb concentration and a determined Mean Corpuscular Hemoglobin (MCH). The invention also relates to a system for executing the method.

公开(公告)号：EP2770318B1

公开(公告)日：2018-03-21

申请号：EP13156233.2

申请日：2013-02-21

Applicant: Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

Inventor： Klinec, Darko

IPC: G01N21/25 ,  G01N21/31 ,  G01N21/51 ,  G01N35/02 ,  G01N35/10 ,  G01N33/49 ,  G01N15/06 ,  G01N21/13 ,  G01N35/04 ,  G01N15/04

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/13 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: Method for detecting clots (1) in a liquid (2), the liquid (2) being comprised in a sample container (3), the method comprising the steps: a) irradiating light having a first wavelength to the sample container (3) by means of a first light source (4) at a changeable vertical irradiating position (P_0 to P_n), such that the light irradiated by the first light source (4) passes through the sample container (3) along a first measurement path, b) measuring an intensity of light having the first wavelength passing along the first measurement path and exiting the sample container (3), and c) detecting clots (1) in response to the measured intensity.