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    TUBE FOR SEPARATING PORTIONS OF A SAMPLE
    2.
    发明公开
    TUBE FOR SEPARATING PORTIONS OF A SAMPLE 审中-实审

    公开(公告)号：EP4371666A3

    公开(公告)日：2024-08-07

    申请号：EP24167492.8

    申请日：2010-07-02

    申请人： Protedyne Corporation

    发明人： MASSARO, Peter

    IPC分类号： B01L3/14 ,  G01N33/50 ,  B01L3/00 ,  G01N33/49

    CPC分类号： B01L3/502 ,  B01L3/5082 ,  B01L2300/068120130101 ,  B01L2300/085820130101 ,  G01N33/491 ,  Y10T436/25375

    摘要： A method and tube for separating a sample. The tube is configured to separate agglomerated or clumped material or other sample components having over a particular size from other smaller size portions of the sample. For example, blood clots may be separated from serum of a blood sample. The tube includes a chamber with a closed bottom and a sidewall extending upwardly from the bottom, and a sample inlet branch coupled to the chamber. A slit is positioned between the chamber and the sample inlet branch so that after a sample is placed into the sample inlet branch, a portion of the sample having a size smaller than the slit (e.g., liquid material) passes through the slit and into the chamber, and material in the sample having a size larger than the slit remains in the sample inlet branch.

    PROCOAGULANT FACTORS SUITABLE FOR SUBSEQUENT AUTOLOGOUS USE
    6.
    发明公开
    PROCOAGULANT FACTORS SUITABLE FOR SUBSEQUENT AUTOLOGOUS USE 审中-公开

    公开(公告)号：EP3400437A1

    公开(公告)日：2018-11-14

    申请号：EP17700620.2

    申请日：2017-01-06

    申请人： Reapplix APS

    发明人： LUNDQUIST, Rasmus ,  HOLM, Niels, Erik

    IPC分类号： G01N33/49 ,  A61B5/15 ,  B01L3/00

    CPC分类号： G01N33/491 ,  A61B5/1438 ,  A61B5/15003 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/154 ,  B01L3/505 ,  B01L3/5082

    摘要： The present invention relates to a blood collection unit suitable for accelerated blood coagulation of whole blood for subsequent autologous or allogeneic use. The blood collection unit is characterised in that its inside surface comprises an activation site accelerating coagulation by having a high roughness. Further, the present invention relates to a blood collection unit characterised in that its inside surface comprises an activation site having a high roughness area, and in that the interior of said blood collection unit has been prepared with a pressure of no more than 255 mBar, and preferably a pressure of no more than 130 mBar. Thereby, a blood collection unit rapidly providing coagulated blood products is provided. Said blood products are separated effectively into blood serum and a blood clot absent of additives and contaminants which would make the blood unsuited for certain uses, such as blood testing/analysis, and LeucoPatch®.

    IMPROVED METHOD AND APPARATUS FOR SEPARATING AND HARVESTING CELLS FROM A WHOLE BLOOD SAMPLE
    8.
    发明授权
    IMPROVED METHOD AND APPARATUS FOR SEPARATING AND HARVESTING CELLS FROM A WHOLE BLOOD SAMPLE 有权

    公开(公告)号：EP2129767B1

    公开(公告)日：2018-09-26

    申请号：EP08868115.0

    申请日：2008-02-22

    申请人： Beckman Coulter, Inc.

    发明人： APARICIO, Carlos ,  RABELLINO, Enrique

    IPC分类号： B04B5/00 ,  G01N33/49

    CPC分类号： G01N33/491

    摘要： The present specification discloses an automated method and apparatus useful for separating and harvesting cells of interest, e.g., mononuclear cells, in a whole blood sample. The method of the invention uses the aspirating/dispensing probe of an automated sample preparation instrument to underlay a density gradient medium beneath a whole blood sample in a centrifugation tube, and the same probe is used to harvest cells of interest from a cell layer formed in the tube as a result of a centrifugation step. In harvesting cells, the probe is advanced inside the tube by a fixed, predetermined distance at which the probe tip (i.e., its aspiration port) is known to be located at, or within a predetermined distance below, the bottom of the cell layer. A predetermined volume of liquid is then aspirated through the probe tip, whereby most cells of interest (and more than 90% of those cells that can be harvested by a flawless manual method) are removed from the cell layer and collected for analysis. Preferably, the probe is caused to move laterally with respect to the tube during the aspiration of the cell layer, whereby cells offset from the center of the container are readily harvested.