公开(公告)号：EP1560804B1

公开(公告)日：2009-04-29

申请号：EP03772310.3

申请日：2003-11-06

Applicant: Dipharma Francis S.r.l.

Inventor： FRANCESCUTTI, Nevio ,  SCUBLA, Tiziano ,  GORASSINI, Fausto ,  CASTALDI, Graziano

IPC: C07C201/02 ,  C07C203/04 ,  C01B21/46

CPC classification number: C01B21/46 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the preparation of compounds of formula: HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with 'stabilised' nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

公开(公告)号：EP1720822A1

公开(公告)日：2006-11-15

申请号：EP05715339.7

申请日：2005-02-15

Applicant: Dynamit Nobel GmbH Explosivstoff- und Systemtechnik

Inventor： ANTES, Jürgen ,  BOSKOVIC, Dusan ,  HAASE, Jürgen ,  LÖBBECKE, Stefan ,  RULOFF, Cornelius ,  TÜRCKE, Tobias

IPC: C07C201/02 ,  C07C203/06

CPC classification number: C07C201/02 ,  B01J19/0093 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00889 ,  C07C203/06

Abstract: The invention relates to a method for the production of liquid nitrate esters, e.g. nitro-glycerine, wherein an alcohol is esterified by means of nitrating acid and the reaction takes place in one or several microreactors.

公开(公告)号：EP1147074A1

公开(公告)日：2001-10-24

申请号：EP00904925.5

申请日：2000-01-18

Applicant: NICOX S.A.

Inventor： DEL SOLDATO, Piero ,  GARUFI, Michele

IPC: C07C203/04 ,  C07C201/02 ,  C07C69/90 ,  C07D209/28

CPC classification number: C07C69/86 ,  C07C201/02 ,  C07D209/28 ,  C07C203/04

Abstract: The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.

公开(公告)号：EP0129995A2

公开(公告)日：1985-01-02

申请号：EP84303752.4

申请日：1984-06-04

Applicant: AECI LIMITED

Inventor： Stiff, Anthony John

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: The invention concerns a process for the preparation of nitric acid esters of organic hydroxy compounds by reacting an organic hydroxy compound with nitric acid in the presence of sulphuric acid and in a solvent, followed by separating off the spent acid, substantially neutralizing the residual acidity of the organic solution, and removing solvent to leave the organic nitrate. From 95% to 220% of the stoichiometric requirement of nitric acid for complete nitration is used. The mole ratio of water to sulphuric acid at the end ofthe reaction is from 0,2:1 to 2,5:1. From 200 to 2000 ml of solvent per mole of hydroxy group is present. Yields of at least 92% are obtained. The invention is particularly suitable for the preparation of alkyl nitrates, alkylene or polyalkylene glycol, monoalkyl ether mononitrates, alkylene or polyalkylene glycol dinitrates, diol nitrates, nitrates containing homocyclic or heterocyclic rings, or nitrates derived from polyols.

Abstract translation: 本发明涉及一种通过有机羟基化合物与硝酸在硫酸存在下和溶剂中反应制备有机羟基化合物的硝酸酯的方法，然后将废酸分离出来，基本上中和残余酸度 有机溶液，并除去溶剂留下有机硝酸盐。 使用硝酸完全硝化的化学计量要求的95％至220％。 反应结束时水与硫酸的摩尔比为0.2:1〜2.5:1。 存在每摩尔羟基200至2000ml溶剂。 产率至少为92％。 本发明特别适用于制备烷基硝酸盐，亚烷基或聚亚烷基二醇，单烷基醚单硝酸盐，亚烷基二醇二烷基二醇二醇，二醇硝酸盐，含有环状或杂环的硝酸盐，或由多元醇衍生的硝酸盐。

公开(公告)号：EP4028384B1

公开(公告)日：2023-11-08

申请号：EP20761871.1

申请日：2020-09-02

Inventor： FRASSETTO, Timo ,  VOGT, Florian ,  YERANDE, Swapnil ,  ALZNAUER, Christiane ,  ILLIES, Sebastian ,  MUELHEIMS, Philip ,  SAELINGER, Daniel ,  THIELE, Robin ,  SUTORIS, Heinz Friedrich

IPC: C07C201/02 ,  C07C201/08 ,  C07C203/08 ,  C07C205/11

公开(公告)号：EP4103540B1

公开(公告)日：2023-11-01

申请号：EP21703224.2

申请日：2021-02-02

Inventor： FRASSETTO, Timo ,  VOGT, Florian ,  ALZNAUER, Christiane ,  ILLIES, Sebastian ,  MUELHEIMS, Philip ,  YERANDE, Swapnil ,  SAELINGER, Daniel ,  THIELE, Robin ,  SUTORIS, Heinz, Friedrich ,  HOFRICHTER, Marcel

IPC: C07C201/02 ,  C07C201/12 ,  C07C205/06 ,  C07C205/45 ,  C07C45/64

公开(公告)号：EP4139277A1

公开(公告)日：2023-03-01

申请号：EP21720267.0

申请日：2021-04-21

Applicant: DSM IP Assets B.V.

Inventor： RIEBEL, Peter Hans ,  WILDERMANN, Angela

IPC: C07C201/02 ,  C07C67/08 ,  C07C69/16 ,  C07C203/04

公开(公告)号：EP4103540A1

公开(公告)日：2022-12-21

申请号：EP21703224.2

申请日：2021-02-02

Applicant: BASF Agro B.V.

Inventor： FRASSETTO, Timo ,  VOGT, Florian ,  ALZNAUER, Christiane ,  ILLIES, Sebastian ,  MUELHEIMS, Philip ,  YERANDE, Swapnil ,  SAELINGER, Daniel ,  THIELE, Robin ,  SUTORIS, Heinz, Friedrich ,  HOFRICHTER, Marcel

IPC: C07C201/02 ,  C07C201/12 ,  C07C205/06 ,  C07C205/45 ,  C07C45/64

公开(公告)号：EP3849961A1

公开(公告)日：2021-07-21

申请号：EP19763009.8

申请日：2019-09-10

Applicant: DSM IP Assets B.V.

Inventor： EGGEL, Michael ,  KAPFERER, Peter ,  LUETHI, Erika

IPC: C07C201/02 ,  C07C203/04 ,  A61K31/04 ,  A61K31/045 ,  A23K20/105 ,  A23K50/10

公开(公告)号：EP3008036B1

公开(公告)日：2017-08-02

申请号：EP14733160.7

申请日：2014-06-25

Applicant: Josef Meissner GmbH & Co. KG

Inventor： PÖHLMANN, Jürgen ,  HERMANN, Heinrich ,  HÄNDEL, Mirko ,  GEBAUER, Jürgen

IPC: B01D11/04 ,  B01J19/18 ,  C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  B01D11/0473 ,  B01J19/1812 ,  C07C203/04