公开(公告)号：EP2984159B1

公开(公告)日：2019-06-12

申请号：EP14716354.7

申请日：2014-04-10

申请人： PURAC Biochem BV

发明人： VERKUIJL, Bastiaan Jeroen Victor ,  KOK, Symone

IPC分类号： C11C3/04 ,  A61K8/37 ,  A61Q17/00 ,  A61Q19/00 ,  A61K31/23

公开(公告)号：EP3429578A1

公开(公告)日：2019-01-23

申请号：EP17727369.5

申请日：2017-03-14

申请人： Team Foods Colombia S.a.

发明人： BETANCOURT-VILLAMIZAR, Eddy, C. ,  MURCILLO-ROJAS, Juan ,  BETANCOURT-CORTES, Ruben

IPC分类号： A61K31/22 ,  A61K31/23 ,  A61K31/355 ,  A61K31/365 ,  A61K31/4188 ,  A61K31/685 ,  A61K36/53 ,  A61K31/519 ,  A61K36/63

公开(公告)号：EP2729015B1

公开(公告)日：2019-01-02

申请号：EP12730585.2

申请日：2012-07-03

申请人： Purac Biochem bv

发明人： KOK, Symone ,  VOGIATZIS, Nikolaos

IPC分类号： A23K40/10 ,  A23K20/105 ,  A23K20/158 ,  A23K20/24 ,  A23K50/75 ,  A61K31/23

公开(公告)号：EP3395328A1

公开(公告)日：2018-10-31

申请号：EP18162319.0

申请日：2014-05-09

申请人： Topokine Therapeutics, Inc.

发明人： SINGER, Michael, S. ,  KALAYOGLU, Murat, V.

IPC分类号： A61K9/00 ,  A61K47/06 ,  A61K47/14 ,  A61K9/06 ,  A61K31/5575 ,  A61K31/23 ,  A61K47/10

CPC分类号： A61K47/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/23 ,  A61K31/5575 ,  A61K47/06 ,  A61K47/10 ,  A61K2300/00

摘要： Described herein are compositions comprising a prostaglandin FP receptor agonist (PFPRA) compound and a fatty acid ester ( e . g ., isopropyl myristate), optionally comprising an ointment base such as a hydrocarbon base ( e . g ., petroleum jelly) and/or an organic alcohol ( e . g ., propylene glycol), that, when topically applied to the skin, locally delivers a therapeutically effective amount of the PFPRA compound to subcutaneous fat under the skin, and methods of preparation. The therapeutic effect is, for example, reduction of the subcutaneous fat under the skin. Further provided are methods of reducing body fat in a subject comprising topically administering the composition to the subject.

公开(公告)号：EP3377057A1

公开(公告)日：2018-09-26

申请号：EP17736436.1

申请日：2017-01-06

申请人： Conagen Inc.

发明人： CHEN, Hui ,  YU, Xiaodan

IPC分类号： A61K31/21 ,  A61K31/23 ,  A61K31/231 ,  A61K31/25

CPC分类号： C07C67/56 ,  C07C67/54 ,  C07C67/58 ,  C12N9/1029 ,  C12N9/93 ,  C12N15/52 ,  C12P7/22 ,  C07C69/28 ,  C07C69/533

摘要： Provided herein are methods of making capsinoids including providing a capsiate synthase in a mixture or cellular system, feeding 8-methyl-6-nonenoyl-CoA, 6E-8-methylnonenoic acid or 8-methylnonanoic acid into the mixture or cellular system, feeding vanillyl alcohol into the mixture or cellular system, and collecting capsinoids from the mixture or cellular system.

公开(公告)号：EP2001293B1

公开(公告)日：2018-08-29

申请号：EP07797196.8

申请日：2007-04-03

申请人： Accera, Inc.

发明人： HENDERSON, Samuel T

IPC分类号： A61K31/19 ,  A61K31/22 ,  A61K31/23 ,  A61L31/06 ,  A61P25/28

CPC分类号： A61K31/22 ,  A23L2/52 ,  A23L33/10 ,  A61K9/0056 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/23

摘要： This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.

公开(公告)号：EP3270883A4

公开(公告)日：2018-07-25

申请号：EP16765854

申请日：2016-03-18

申请人： CALLION PHARMA LLC

发明人： PAPAS KONSTANTINO ANDREAS

IPC分类号： A61K31/07 ,  A61K31/015 ,  A61K31/122 ,  A61K31/203 ,  A61K31/23 ,  A61K31/355 ,  A61K31/592 ,  A61K31/593 ,  A61P43/00

CPC分类号： A61K31/593 ,  A61K9/08 ,  A61K9/48 ,  A61K31/015 ,  A61K31/07 ,  A61K31/122 ,  A61K31/203 ,  A61K31/23 ,  A61K31/355 ,  A61K31/592 ,  A61K2300/00

摘要： A scalable vitamin composition unit dosage adapted to treat a fat-soluble vitamin deficiency in a subject is provided herein, the unit dosage consisting essentially of vitamin D, vitamin E, vitamin K, and vitamin A, wherein the unit dosage is substantially free of additional vitamins and wherein the unit dosage is scalable based on the weight, age, and condition of a subject without inducing toxic effects. Also provided are methods of treating a fat-soluble vitamin deficiency in a subject in need thereof by administering to the subject an effective amount of a unit dosage as described herein.

公开(公告)号：EP2934152B1

公开(公告)日：2017-11-08

申请号：EP13864064.4

申请日：2013-09-30

申请人： Sepsicure L.L.C.

发明人： LEVINE, Daniel, M. ,  PARKER, Thomas, S. ,  GORDON, Bruce, R. ,  SAAL, Stuart, D.

IPC分类号： A01N57/26 ,  A61K31/23 ,  A61K31/575 ,  A61K31/685 ,  A61P31/00 ,  A61K9/107

CPC分类号： A61K31/575 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/23 ,  A61K31/685 ,  A61K2300/00

公开(公告)号：EP2752202B1

公开(公告)日：2017-10-04

申请号：EP12827786.0

申请日：2012-08-31

申请人： Fujifilm Corporation

发明人： HARAGUCHI, Nobuyuki ,  SAKAGUCHI, Hiroyuki

IPC分类号： A61K9/48 ,  A61K47/10 ,  A61K9/107 ,  A23L29/10 ,  A23L33/115 ,  A61K31/23 ,  A61K36/05 ,  A61K31/202

CPC分类号： A61K9/4833 ,  A23L29/10 ,  A23L33/115 ,  A61K9/1075 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/202 ,  A61K31/23 ,  A61K36/05

公开(公告)号：EP1869979B1

公开(公告)日：2017-09-20

申请号：EP07109965.9

申请日：2007-06-11

申请人： Alpha-Biocare GmbH

发明人： Mehlhorn, Heinz ,  Schmidt, Jürgen ,  Schmal, Günter

IPC分类号： A01N37/12 ,  A01N37/36 ,  A61K31/22 ,  A61K31/23

CPC分类号： A01N37/12 ,  A01N37/36