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公开(公告)号：EP4440626A1
公开(公告)日：2024-10-09
申请号：EP22902419.5
申请日：2022-12-02
IPC分类号： A61K48/00 , A61K35/761 , C12N9/02 , A61P21/00 , A61K35/76
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公开(公告)号：EP4440587A2
公开(公告)日：2024-10-09
申请号：EP22902161.3
申请日：2022-12-01
发明人： SWEM, Lee Robert , KUMAR, Pawan , TRIPATHI, Shital A. , BHALLA, Aditya , PARMAR, Anupreet , HAMILTON, Joshua J. , BRUMBAUGH, Ariel R. , RICCI, Dante P. , LAYMAN, Hans Richard William , CIGLAR, Ariana M. , BERLEMAN, James , WALTERS, Zachary , JACOBY, Kyle , YOUNGBLUT, Nicholas D. , GRAUER, Andreas , CONLEY, Emily Drabant , ROMASKO, Heather
CPC分类号： A61K38/51 , A61K38/45 , A61P13/04 , C12R2001/0020210501 , C07K14/195 , C12N9/13 , C12N9/88 , C12Y208/03016 , C12Y401/01008 , C12N15/52 , C12N1/20 , A61K35/74 , A61K45/06 , A61K31/713
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公开(公告)号：EP4438727A2
公开(公告)日：2024-10-02
申请号：EP24150862.1
申请日：2017-02-08
申请人： Synaffix B.V.
发明人： van Geel, Remon , Wijdeven, Maria Antonia , Hurkmans, Inge Catharina Josephina , van Delft, Floris Louis , van Berkel, Sander Sebastiaan
IPC分类号： C12N9/24
CPC分类号： C12Y302/01096 , C12N9/24 , C07K2319/0020130101 , C12N9/2497 , C12N15/52 , C12N15/62
摘要： The invention concerns fusion proteins, wherein two endoglycosidases are fused, possibly via a linker. The fusion enzymes according to the invention have structure (1): EndoX-(L)p-EndoY (1), wherein EndoX is an endoglycosidase, EndoY is an endoglycosidase distinct from EndoX, L is a linker and p is 0 or 1. Such fusion enzymes capable of trimming glycoproteins comprising at least two distinct glycoforms in a single step. The invention further concerns the use of the fusion enzyme according to the invention for trimming glycoproteins. In another aspect, the invention relates to the process of production of the fusion enzyme. In a further aspect, the inventions concerns a process for trimming glycoproteins, comprising trimming the glycoprotein with a fusion enzyme according to the invention, to obtain a trimmed glycoprotein.
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公开(公告)号：EP4430194A2
公开(公告)日：2024-09-18
申请号：EP22893860.1
申请日：2022-11-11
CPC分类号： C12Q1/6886 , C12Q2600/15620130101 , C12Q1/6897 , C12N9/78 , C12Y305/04004 , C12N15/52
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公开(公告)号：EP3589309B1
公开(公告)日：2024-09-18
申请号：EP18842766.0
申请日：2018-09-20
CPC分类号： C12N15/52 , C12Y304/22028 , A61K39/12 , C12N2770/3203420130101 , C12N2770/3202220130101 , C12N9/506
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公开(公告)号：EP4423259A1
公开(公告)日：2024-09-04
申请号：EP22888477.1
申请日：2022-10-26
申请人： Genomatica, Inc.
发明人： SHAH, Amit, Mahendra , ZHANG, Deqiang , WARNER, Joseph, Roy , GRIFFIN, Benjamin, Matthew , SHAH, Jinel , COLQUITT, Justin, Robert
CPC分类号： C12N9/0008 , C12N9/1096 , C12Y206/01 , C12N15/52 , C12N15/70 , C12P7/18 , C12P13/001 , C12P13/005
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公开(公告)号：EP4419690A2
公开(公告)日：2024-08-28
申请号：EP22884659.8
申请日：2022-10-18
发明人： WILSON, James, M. , SCHMID, Ralf
CPC分类号： C12N15/86 , C12N2750/1414320130101 , C12Y207/11022 , C12N9/12 , C12N15/52 , A61P25/00 , A61K48/005 , A61K48/0066 , A61K48/0083
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公开(公告)号：EP4416273A1
公开(公告)日：2024-08-21
申请号：EP22881889.4
申请日：2022-10-17
申请人： Cellibre, Inc.
发明人： KAMBOURAKIS, Spiros , KOMOR, Russell, Scott , KEUL, Nicholas, Donald , CAIAZZA, Nicky, Christopher , URANO, Jun , NGUYEN, Diep Minh, Ngoc
CPC分类号： C12N15/52 , C12N15/815 , C12P7/42 , C12P17/06 , C12N9/0004 , C12R2001/64520210501 , C07K2319/0220130101 , C07K2319/0020130101 , C12R2001/0120210501
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10.发明授权
公开(公告)号：EP3153574B1
公开(公告)日：2024-08-21
申请号：EP15802588.2
申请日：2015-06-05
CPC分类号： C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N15/52 , C12Y102/01011 , C12Y203/01031 , C12Y206/01001 , C12Y207/01039 , C12Y207/02004 , C12Y401/01031 , C12Y402/01022 , C12P13/06 , C12R2001/1220210501 , C12N1/205
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