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103 条记录 (耗时 0.142 秒)

    DETECTION OF ALPHA, BETA-DICARBONYL COMPOUNDS WITH FLUOROGENIC PROBES
    44.
    发明公开
    DETECTION OF ALPHA, BETA-DICARBONYL COMPOUNDS WITH FLUOROGENIC PROBES 审中-公开
    NACHWEIS VON ALPHA，BETA-DICARBONYLVERBINDUNGEN MIT FLUORGENEN SONDEN

    公开(公告)号：EP3030904A1

    公开(公告)日：2016-06-15

    申请号：EP13750122.7

    申请日：2013-08-09

    申请人： The University Of Warwick

    发明人： THORNALLEY, Paul ,  RABBANI, Naila

    IPC分类号： G01N33/52 ,  G01N33/50

    CPC分类号： G01N33/64 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/52 ,  G01N33/582 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/102 ,  G01N2800/16 ,  G01N2800/166 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/2871 ,  G01N2800/301 ,  G01N2800/302 ,  G01N2800/32 ,  G01N2800/321 ,  G01N2800/323 ,  G01N2800/347 ,  G01N2800/368 ,  G01N2800/7042

    摘要： The disclosure relates to a fluorescence based assay for the detection of alpha, beta-dicarbonyl containing compounds, for example alpha-oxoaldehyde compounds such as glyoxal, methylglyoxal, hydroxypyruvaldehyde, erythrosone, 3-deoxyerythrosone, ribosone, 3- deoxyribosone, glucosone, 3-deoxyglucosone and stereoisomers thereof and butan-2,3- dione that uses a fluorogenic probe which is stable under ambient conditions. The fluorogenic probes comprise a 1,2-diaminophenyl moiety. The diaminophenyl probes yield a 20-fold increase in quantum yield when they are a derivative of fluorescein (DAF), rhodamine (DAR), BODIPY or cyanine. The assay is preferably carried out at pH 4-8. Corresponding screening methods for modulators of alpha, beta-dicarbonyl compound concentrations are also disclosed.

    摘要翻译： 本公开涉及用于检测α，β-二羰基化合物的荧光基测定法，例如α-氧代醛化合物，例如乙醛酸，甲基乙二醛，羟基吡喃甲醛，赤藓酮，3-脱氧 - 赤藓酮，核糖，3-脱氧核糖，葡萄糖， 3-脱氧葡萄糖酮及其立体异构体和丁-2,3-二酮，其使用在环境条件下稳定的荧光探针。 荧光探针包含1,2-二氨基苯基部分。 当它们是荧光素（DAF），罗丹明（DAR），BODIPY或花青的衍生物时，二氨基苯基探针的量子产率增加20倍。 该测定优选在pH 4-8下进行。 还公开了α，β-二羰基化合物浓度调节剂的相应筛选方法。

    SCANNING ELECTROCHEMICAL MICROSCOPY
    45.
    发明公开
    SCANNING ELECTROCHEMICAL MICROSCOPY 审中-公开
    ELEKTROCHEMISCHE RASTERMIKROSKOPIE

    公开(公告)号：EP2558871A1

    公开(公告)日：2013-02-20

    申请号：EP11716297.4

    申请日：2011-04-14

    申请人： The University Of Warwick

    发明人： UNWIN, Patrick ,  MCKELVEY, Kim Martin

    IPC分类号： G01Q60/60

    CPC分类号： G01Q60/60 ,  B22D19/14 ,  C23C26/02 ,  E21C35/183 ,  E21C2035/1806 ,  E21C2035/1809 ,  E21C2035/1813 ,  Y10T428/12937 ,  Y10T428/12965

    摘要： A new scanning electrochemical microscopy tip positioning method that allows topography and surface activity to be resolved independently is presented. A SECM tip is oscillated relative to the surface of interest. Changes in the oscillation amplitude, caused by the intermittent contact of the SECM tip with the surface of interest, are used to detect the surface of interest, and as a feedback signal for various types of imaging.

    摘要翻译： 提出了一种能够独立解决地形和表面活动的新型扫描电化学显微镜尖端定位方法。 SECM尖端相对于感兴趣的表面振荡。 由SECM尖端与感兴趣的表面的间歇接触引起的振荡幅度的变化用于检测感兴趣的表面，并且用作各种成像的反馈信号。

    NANOTUBE ELECTROCHEMISTRY
    48.
    发明公开
    NANOTUBE ELECTROCHEMISTRY 审中-公开
    碳纳米管电化学

    公开(公告)号：EP2384433A1

    公开(公告)日：2011-11-09

    申请号：EP09799680.5

    申请日：2009-12-11

    申请人： The University Of Warwick

    发明人： MACPHERSON, Julie, V. ,  UNWIN, Patrick, R. ,  DUMITRESCU, Ioanna ,  EDGEWORTH, Jonathan, P.

    IPC分类号： G01N27/30

    CPC分类号： G01N27/308 ,  B82Y30/00

    摘要： An electrode for electrochemical analysis is described, the electrode comprising: an insulating surface; a three-dimensional network of carbon nanotubes situated on the insulating surface; and an electrically conducting material in electrical contact with the carbon nanotubes; wherein the carbon nanotubes are oriented substantially parallel to the insulating surface. Also described is a method of manufacturing the electrode, and a method of electrochemically analysing a solution using electrodes of this type, and an associated assay device or kit.

    BORON-DOPED DIAMOND
    49.
    发明公开
    BORON-DOPED DIAMOND 审中-公开
    BOR-掺杂金刚石

    公开(公告)号：EP2350631A1

    公开(公告)日：2011-08-03

    申请号：EP09784518.4

    申请日：2009-01-06

    申请人： The University Of Warwick

    发明人： UNWIN, Patrick ,  MACPHERSON, Julie ,  NEWTON, Mark

    IPC分类号： G01N27/30 ,  G01N27/49 ,  C04B41/88 ,  C30B33/00

    CPC分类号： C04B41/5122 ,  C04B41/009 ,  C04B41/88 ,  C30B29/04 ,  C30B33/005 ,  G01N27/308 ,  G01N27/404 ,  C04B41/4549 ,  C04B41/4564 ,  C04B41/5353 ,  C04B35/52

    摘要： The invention relates to a method for preparing metal nanoparticle-modified boron-doped diamond the method comprising generating a strong oxidising agent by acid treating a front surface of the boron-doped diamond prior to deposition of the metal nanoparticles onto the front surface of the boron-doped diamond. The metal nanoparticle-modified boron-doped diamond resulting from the acid wash has a front surface which is oxygen terminated. The metal nanoparticle-modified boron-doped diamond may be used in electrodes as an oxygen sensor, the electrode may be made by preparing a boron-doped diamond column; insulating the column so that only a front surface of the column is exposed; polishing the front surface of the column; acid-treating the front surface of the column; and depositing metal nanoparticles onto the front surface of the column.