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公开(公告)号：EP1147183A1
公开(公告)日：2001-10-24
申请号：EP00900795.6
申请日：2000-01-19
申请人： Compugen Ltd.
发明人： MINTZ, Liat , SAVITZKY, Kinneret
IPC分类号： C12N15/00 , C07K14/705 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/70571 , G01N33/566 , G01N2333/70571
摘要： The invention concerns novel nucleic acid sequences which have homology to the serotonin receptor. The invention also concerns amino acid sequences encoded by the nucleic acid sequence.
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公开(公告)号：EP4245374A3
公开(公告)日：2024-07-10
申请号：EP23162663.1
申请日：2023-03-17
申请人： Compugen Ltd.
发明人： Granit, Roy Z. , Cojocaru, Gad S. , Ophir, Eran , Novik, Amit , Sabath, Niv , Alteber, Zoya
IPC分类号： A61P35/00 , C07K16/28 , G01N33/574
CPC分类号： A61P35/00 , C07K16/28 , C07K2317/7620130101 , G01N33/57492 , Y02A50/30 , G01N2333/7059620130101
摘要： The present invention provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.
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公开(公告)号：EP4245374A2
公开(公告)日：2023-09-20
申请号：EP23162663.1
申请日：2023-03-17
申请人： Compugen Ltd.
发明人： Granit, Roy Z. , Cojocaru, Gad S. , Ophir, Eran , Novik, Amit , Sabath, Niv , Alteber, Zoya
IPC分类号： A61P35/00 , C07K16/28 , G01N33/574
摘要： The present invention provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.
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公开(公告)号：EP4129320A1
公开(公告)日：2023-02-08
申请号：EP22180817.3
申请日：2016-02-19
申请人： Compugen Ltd.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPELTON, Lance , DRAKE, Andrew W. , GOZLAN, Yosi , VAKNIN, Ilan , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad S. , PRESTA, Leonard , THEOLIS, Richard
IPC分类号： A61K38/00 , C07K14/00 , C07K16/28 , C12N15/113 , A61P35/00
摘要： The present invention is directed to anti-PVRIG antibodies and methods of using same.
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公开(公告)号：EP3802605A1
公开(公告)日：2021-04-14
申请号：EP19733259.6
申请日：2019-05-31
申请人： Compugen Ltd.
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公开(公告)号：EP3630180A1
公开(公告)日：2020-04-08
申请号：EP18749490.1
申请日：2018-06-01
申请人： Compugen Ltd.
发明人： LIANG, Spencer , LEUNG, Ling , WHELAN, Sarah , KOTTURI, Maya , MACHLENKIN, Arthur , OPHIR, Eran , ALTEBER, Zoya , AZULAY, Meir , LOGRONIO, Kathryn , KUMAR, Sandeep , DESAI, Radhika , CHAN, Christopher
IPC分类号： A61K39/395 , C07K16/28
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公开(公告)号：EP3347379B9
公开(公告)日：2020-03-25
申请号：EP17797429.2
申请日：2017-08-17
申请人： Compugen Ltd.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPLETON, Lance , DRAKE, Andrew, W. , GOZLAN, Yosi , VAKNIN, Ilan , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad., S. , KOTTURI, Maya , CHENG, Hsin-Yuan , HANSEN, Kyle , GILADI, David, Nisim , SAFYON, Einav , OPHIR, Eran , PRESTA, Leonard , THEOLIS, Richard , DESAI, Radhika , WALL, Patrick
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48.发明公开POLYPEPTIDES AND USES THEREOF AS A DRUG FOR TREATMENT OF AUTOIMMUNE DISORDERS 审中-公开多肽及其用作治疗自身免疫性疾病的药物
公开(公告)号：EP3185885A1
公开(公告)日：2017-07-05
申请号：EP15836989.2
申请日：2015-08-26
申请人： Compugen Ltd.
IPC分类号： A61K38/17 , A61P37/06 , C07K14/705 , C07K16/46
摘要： This invention, in at least some embodiments, relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.
摘要翻译： 在至少一些实施方案中，本发明涉及蛋白质C1ORF32及其变体和片段及其融合蛋白，以及用于免疫疗法和药物开发的方法，包括但不限于免疫调节剂和用于免疫疗法，包括 用于自身免疫性疾病。
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49.发明公开ANTI-VSTM5 ANTIBODIES AND THE USE THEREOF IN THERAPY AND DIAGNOSIS 审中-公开诊断中的VERM5-ANTIKÖRPER在DER THERAPIE UND VERWENDUNG DAVON
公开(公告)号：EP3043819A4
公开(公告)日：2017-04-05
申请号：EP14844096
申请日：2014-09-11
申请人： COMPUGEN LTD
发明人： LEVINE ZURIT , ROTMAN GALIT , DASSA LIAT , LEVY OFER , COJOCARU GAD S , TOPORIK AMIR , KLIGER YOSSEF , POW ANDREW , LIANG SPENCER
IPC分类号： A61K39/395 , A61P31/00 , A61P35/00 , C07K16/18 , C07K16/30 , G01N33/564 , G01N33/569 , G01N33/574
CPC分类号： C07K16/28 , A61K31/664 , A61K38/00 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/5154 , C07K14/705 , C07K16/2803 , C07K16/2818 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/564 , G01N33/57492 , G01N2800/24 , G01N2800/26 , G01N2800/50 , G01N2800/52 , G01N2800/54 , G01N2800/56 , A61K31/675 , A61K2039/5152 , A61K38/1774
摘要： The present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same, for modulating (antagonizing or agonizing) one or more of the effects of VSTM5 expression on immunity. More specifically, the present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same for treating and aiding in the diagnosis of cancer, infectious diseases and immune related diseases, e.g., those associated with aberrant (higher or lower than normal) VSTM5 expression by diseased and/or immune cells and/or aberrant (increased or reduced) VSTM5-mediated effects on immunity.
摘要翻译： 本发明涉及VSTM5特异性抗体，抗体片段和VSTM5多肽，包含其的缀合物和组合物，用于调节（拮抗或激动）VSTM5表达对免疫的一种或多种作用。 更具体地，本发明涉及VSTM5特异性抗体，抗体片段和VSTM5多肽，包含其的组合物和组合物，用于治疗和辅助诊断癌症，感染性疾病和免疫相关疾病，例如与异常（更高 或低于正常）VSTM5表达通过患病和/或免疫细胞和/或异常（增加或减少）VSTM5介导的对免疫的作用。
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50.发明授权Antibody specific for heparanase splice variant T5 and its use. 有权Heparanase Spice-Variante T5 spezifischerAntikörperund dessen Verwendung。
公开(公告)号：EP2507265B1
公开(公告)日：2016-05-11
申请号：EP10805501.3
申请日：2010-11-30
申请人： Compugen Ltd.
发明人： SHEMESH, Ronen , AYALON-SOFFER, Michal , LEVINE, Zurit , NEMZER, Sergey , ZEKHARYA, Tomer , COJOCARU, Gad S. , BARASH, Uri , ILAN, Neta , VLODAVSKY, Israel , HECHT, Iris
IPC分类号： C07K16/40 , C07K16/30 , C12N9/24 , C12N15/113
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
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