公开(公告)号：EP2726503A1

公开(公告)日：2014-05-07

申请号：EP12804342.9

申请日：2012-07-01

申请人： Compugen Ltd.

发明人： HECHT, Iris ,  TOPORIK, Amir ,  ROSENBERG, Avi Yeshah ,  ROTMAN, Galit ,  LEVINE, Zurit

IPC分类号： C07K14/705 ,  C07K16/46 ,  A61K38/17 ,  A61P37/06

CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/74 ,  C12N5/0636 ,  Y02A50/401

摘要： This invention relates to C1ORF32 protein and its variants and fragments and fusion proteins thereof, pharmaceutical composition comprising same and methods of use thereof for treatment of immune related disorders and infections.

公开(公告)号：EP2064234B1

公开(公告)日：2011-11-02

申请号：EP07875175.7

申请日：2007-09-18

申请人： Compugen Ltd.

发明人： COHEN, Yossi ,  SHEMESH, Ronen ,  TOPORIK, Amir ,  LEVINE, Zurit ,  WOOL, Assaf ,  DAHARY, Dvir ,  HECHT, Iris ,  BEIMAN, Merav ,  ROTMAN, Galit ,  AYALON-SOFFER, Michal

IPC分类号： C07K14/43

CPC分类号： C07K14/47 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  C07K5/101 ,  C07K7/06 ,  C07K7/08

摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

公开(公告)号：EP2240196A2

公开(公告)日：2010-10-20

申请号：EP09703833.5

申请日：2009-01-22

申请人： Compugen Ltd.

发明人： KLIGER, Yossef ,  LEVY, Ofer ,  BORUKHOV, Itamar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TIRAN, Zohar ,  OREN, Anat ,  TOPORIK, Amir

IPC分类号： A61K38/17 ,  C07K14/775 ,  C07K16/18

CPC分类号： C07K14/775 ,  A61K38/00

摘要： The subject invention provides clusterin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

公开(公告)号：EP3202415A2

公开(公告)日：2017-08-09

申请号：EP17161149.4

申请日：2011-06-30

申请人： Compugen Ltd.

发明人： HECHT, Iris ,  ROTMAN, Galit ,  LEVINE, Zurit ,  MILLER, Stephen D. ,  PODOJIL, Joseph R.

IPC分类号： A61K38/17 ,  A61P25/28

CPC分类号： C07K14/4713 ,  A61K38/1709 ,  Y02A50/40 ,  Y02A50/401

摘要： This invention relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use therof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.

公开(公告)号：EP3043819A1

公开(公告)日：2016-07-20

申请号：EP14844096.9

申请日：2014-09-11

申请人： Compugen Ltd.

发明人： LEVINE, Zurit ,  ROTMAN, Galit ,  DASSA, Liat ,  LEVY, Ofer ,  COJOCARU, Gad S. ,  TOPORIK, Amir ,  KLIGER, Yossef ,  POW, Andrew ,  LIANG, Spencer

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  C07K16/30 ,  G01N33/564 ,  G01N33/569

CPC分类号： C07K16/28 ,  A61K31/664 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5154 ,  C07K14/705 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  G01N33/564 ,  G01N33/57492 ,  G01N2800/24 ,  G01N2800/26 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/416 ,  Y02A50/421 ,  Y02A50/466 ,  Y02A50/491 ,  Y02A50/492 ,  Y02A50/55 ,  Y02A50/58 ,  A61K31/675 ,  A61K2039/5152 ,  A61K38/1774

摘要： The present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same, for modulating (antagonizing or agonizing) one or more of the effects of VSTM5 expression on immunity. More specifically, the present invention relates to VSTM5-specific antibodies, antibody fragments, and VSTM5 polypeptides, conjugates and compositions comprising same for treating and aiding in the diagnosis of cancer, infectious diseases and immune related diseases, e.g., those associated with aberrant (higher or lower than normal) VSTM5 expression by diseased and/or immune cells and/or aberrant (increased or reduced) VSTM5-mediated effects on immunity.

公开(公告)号：EP2744830A1

公开(公告)日：2014-06-25

申请号：EP13806165.0

申请日：2013-06-19

申请人： Compugen Ltd.

发明人： COJOCARU, Gady S. ,  DASSA, Liat ,  ROTMAN, Galit ,  LEVY, Ofer ,  POW, Andrew ,  SAMEACH-GREENWALD, Shirley ,  LEVINE, Zurit

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K31/675 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/507 ,  C07K14/70503 ,  C07K16/28 ,  C07K16/2818 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/734 ,  C07K2319/30 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N2800/24 ,  G01N2800/26 ,  Y02A50/412 ,  Y02A50/423 ,  A61K2300/00

摘要： This invention relates to antibodies and antigen binding fragments and conjugates containing same, and/or alternative scaffolds, specific for LSR molecules, which are suitable drugs for immunotherapy and treatment of specific cancer.

公开(公告)号：EP2167534B1

公开(公告)日：2012-07-04

申请号：EP08826161.5

申请日：2008-07-11

申请人： Compugen Ltd.

发明人： SHEMESH, Ronen ,  LEVINE, Zurit ,  TOPORIK, Amir ,  HERMESH, Chen ,  KLIGER, Yossef ,  GOFER, Eyal ,  WOOL, Assaf ,  DAHARY, Dvir ,  COHEN, Yossi

IPC分类号： C07K14/47 ,  A61K38/17 ,  C07K16/18 ,  C12N15/12

CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K7/06 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C07K2317/34

摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

公开(公告)号：EP2167534A2

公开(公告)日：2010-03-31

申请号：EP08826161.5

申请日：2008-07-11

申请人： Compugen Ltd.

发明人： SHEMESH, Ronen ,  LEVINE, Zurit ,  TOPORIK, Amir ,  HERMESH, Chen ,  KLIGER, Yossi ,  GOFER, Eyal ,  WOOL, Assaf ,  DAHARY, Dvir ,  COHEN, Yossi

IPC分类号： C07K14/47 ,  A61K38/17 ,  C07K16/18 ,  C12N15/12

CPC分类号： C07K14/472 ,  A61K38/00 ,  C07K7/06 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C07K2317/34

摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

公开(公告)号：EP1713900A2

公开(公告)日：2006-10-25

申请号：EP05703149.4

申请日：2005-01-27

申请人： Compugen Ltd.

发明人： DIBER, Alex ,  POLLOCK, Sarah ,  LEVINE, Zurit ,  NEMZER, Sergey ,  GREBINSKY, Vladimir ,  MELON, Brian ,  OLSON, Andrew ,  ROSENBERG, Avi ,  HAVIV, Ami ,  ZEVIN, Shaul ,  ZEKHARIA, Tomer ,  SHAKED, Zipi ,  OLSHANSKY, Moshe ,  FARKASH, Ariel ,  PRIVMAN, Eyal ,  NOVIK, Amit ,  KEREN, Naomi ,  COJOCARU, Gad, S. ,  AKIVA, Pinchas ,  SHEMESH, Ronen ,  SELLA-TAVOR, Osnat ,  MINTZ, Liat ,  XIE, Hanqing ,  DAHARY, Dvir ,  LEVANON, Erez ,  FREILICH, Shiri ,  BECK, Nili ,  ZHU, Wei-Yong ,  WASSERMAN, Alon ,  CHERMESH, Chen ,  AZAR, Idit ,  SOREK, Rotem ,  BERNSTEIN, Jeanne ,  COHEN, Yossi

IPC分类号： C12N1/00

CPC分类号： C07K14/705 ,  G06F19/20 ,  G06F19/22 ,  G06F19/28

摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.

公开(公告)号：EP2507265B1

公开(公告)日：2016-05-11

申请号：EP10805501.3

申请日：2010-11-30

申请人： Compugen Ltd.

发明人： SHEMESH, Ronen ,  AYALON-SOFFER, Michal ,  LEVINE, Zurit ,  NEMZER, Sergey ,  ZEKHARYA, Tomer ,  COJOCARU, Gad S. ,  BARASH, Uri ,  ILAN, Neta ,  VLODAVSKY, Israel ,  HECHT, Iris

IPC分类号： C07K16/40 ,  C07K16/30 ,  C12N9/24 ,  C12N15/113

CPC分类号： C07K16/30 ,  C07K16/40 ,  C12N9/2402 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12Y302/01166