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1.发明公开METHODS AND SYSTEMS FOR IDENTIFYING NATURALLY OCCURRING ANTISENSE TRANSCRIPTS AND METHODS, KITS AND ARRAYS UTILIZING SAME 审中-公开方法和系统用于识别自然产生的反义转录和利用套件和数组这些方法
公开(公告)号：EP1451355A1
公开(公告)日：2004-09-01
申请号：EP02788472.5
申请日：2002-11-11
申请人： Compugen Ltd.
发明人： LEVANON, Erez , POLLOCK, Sarah , NEMZER, Sergey , SHOSHAN, Avi , KHOSRAVI, Rami , WALACH, Shira , LEVINE, Zurit , BERNSTEIN, Jeanne , DAHARI, Dvir , WASSERMAN, Alon , ROTMAN, Galit
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6837 , G06F19/20 , G06F19/22 , C12Q2525/149
摘要： A method of identifying putative naturally occurring antisense transcripts is provided. The method is effected by (a) computationally aligning a first database including sense-oriented polynucleotide sequences with a second database including expressed polynucleotide sequences; and (b) identifying expressed polynucleotide sequences from the second database being capable of forming a duplex with at least one sense-oriented polynucleotide sequence of the first database, thereby identifying putative naturally occurring antisense transcripts.
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公开(公告)号：EP1713900A2
公开(公告)日：2006-10-25
申请号：EP05703149.4
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： DIBER, Alex , POLLOCK, Sarah , LEVINE, Zurit , NEMZER, Sergey , GREBINSKY, Vladimir , MELON, Brian , OLSON, Andrew , ROSENBERG, Avi , HAVIV, Ami , ZEVIN, Shaul , ZEKHARIA, Tomer , SHAKED, Zipi , OLSHANSKY, Moshe , FARKASH, Ariel , PRIVMAN, Eyal , NOVIK, Amit , KEREN, Naomi , COJOCARU, Gad, S. , AKIVA, Pinchas , SHEMESH, Ronen , SELLA-TAVOR, Osnat , MINTZ, Liat , XIE, Hanqing , DAHARY, Dvir , LEVANON, Erez , FREILICH, Shiri , BECK, Nili , ZHU, Wei-Yong , WASSERMAN, Alon , CHERMESH, Chen , AZAR, Idit , SOREK, Rotem , BERNSTEIN, Jeanne , COHEN, Yossi
IPC分类号： C12N1/00
CPC分类号： C07K14/705 , G06F19/20 , G06F19/22 , G06F19/28
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
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公开(公告)号：EP3978929A1
公开(公告)日：2022-04-06
申请号：EP21188559.5
申请日：2016-02-19
申请人： Compugen Ltd.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPELTON, Lance , DRAKE, Andrew W. , GOZLAN, Yosi , VAKNIN, Ilan , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad S. , LEVY, Ofer , MACHLENKIN, Arthur , TOPORIK, Amir , KLIGER, Yossef , NEMZER, Sergey , NOVIK, Amit , BENITA, Yair
摘要： The present invention is directed to PVRIG polypeptides and their uses.
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公开(公告)号：EP3259597A2
公开(公告)日：2017-12-27
申请号：EP16711051.9
申请日：2016-02-19
申请人： Compugen Ltd.
发明人： WHITE, Mark , KUMAR, Sandeep , CHAN, Christopher , LIANG, Spencer , STAPLETON, Lance , DRAKE, Andrew W. , GOZLAN, Yosi , VAKNIN, Iian , SAMEAH-GREENWALD, Shirley , DASSA, Liat , TIRAN, Zohar , COJOCARU, Gad, S. , LEVY, Ofer , MACHLENKIN, Arthur , TOPORIK, Amir , KLIGER, Yossef , NEMZER, Sergey , NOVIK, Amit , BENITA, Yair
CPC分类号： C07K16/1009 , A61K2039/507 , C07K7/06 , C07K14/70503 , C07K16/2803 , C07K16/2818 , C07K2317/74 , C07K2319/30 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/502 , G01N33/505 , G01N33/574 , G01N2333/70596 , G01N2500/02 , G01N2500/10 , Y02A50/466
摘要： The present invention is directed to PVRIG polypeptides and their uses.
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5.发明授权Antibody specific for heparanase splice variant T5 and its use. 有权Heparanase Spice-Variante T5 spezifischerAntikörperund dessen Verwendung。
公开(公告)号：EP2507265B1
公开(公告)日：2016-05-11
申请号：EP10805501.3
申请日：2010-11-30
申请人： Compugen Ltd.
发明人： SHEMESH, Ronen , AYALON-SOFFER, Michal , LEVINE, Zurit , NEMZER, Sergey , ZEKHARYA, Tomer , COJOCARU, Gad S. , BARASH, Uri , ILAN, Neta , VLODAVSKY, Israel , HECHT, Iris
IPC分类号： C07K16/40 , C07K16/30 , C12N9/24 , C12N15/113
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
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6.发明授权POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 有权多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
公开(公告)号：EP2190469B1
公开(公告)日：2015-02-25
申请号：EP08829443.4
申请日：2008-09-03
申请人： Compugen Ltd.
发明人： LEVINE, Zurit , ROSENBERG, Avi , ROTMAN, Galit , NOVIK, Amit , TOPORIK, Amir , KINAR, Yaron , NEMZER, Sergey , KOIFMAN, Cynthia , BEIMAN, Merav , DASSA, Liat , WALACH, Shira , MONTIA, Eve , SAMEACH-GREENWALD, Shirley , PERGAM, Tania , MILO, Dalit , COHEN-DAYAG, Anat , LEVY, Ofer , BUBIS, Marina
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.
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公开(公告)号：EP2507265A2
公开(公告)日：2012-10-10
申请号：EP10805501.3
申请日：2010-11-30
申请人： Compugen Ltd.
发明人： SHEMESH, Ronen , AYALON-SOFFER, Michal , LEVINE, Zurit , NEMZER, Sergey , ZEKHARYA, Tomer , COJOCARU, Gad S. , BARASH, Uri , ILAN, Neta , VLODAVSKY, Israel , HECHT, Iris
IPC分类号： C07K16/40
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
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8.发明公开POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 有权多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
公开(公告)号：EP2190469A2
公开(公告)日：2010-06-02
申请号：EP08829443.4
申请日：2008-09-03
申请人： Compugen Ltd.
发明人： LEVINE, Zurit , ROSENBERG, Avi , ROTMAN, Galit , NOVIK, Amit , TOPORIK, Amir , KINAR, Yaron , NEMZER, Sergey , KOIFMAN, Cynthia , BEIMAN, Merav , DASSA, Liat , WALACH, Shira , MONTIA, Eve , SAMEACH-GREENWALD, Shirley , PERGAM, Tania , MILO, Dalit , COHEN-DAYAG, Anat , LEVY, Ofer , BUBIS, Marina
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.
摘要翻译： 本发明涉及一个新的目标生产免疫和非免疫的疗法和用于疾病的诊断。 更具体地，本发明提供针对抗原C1ORF32，被预测的共刺激家庭成员和其中在癌症，包括肺癌，卵巢癌和结肠癌，以及诊断和治疗用途被差分过表达的治疗性抗体。 因此提供了一种用于合成调制B7共刺激抗体的使用。 本发明进一步涉及药物开发C1ORF32的胞外结构域及其变种awhich是用于癌症治疗的合适的目标，和的发现。
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9.发明公开NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开NEW的核苷酸和氨基酸序列和它们在诊断试验和方法
公开(公告)号：EP1716256A2
公开(公告)日：2006-11-02
申请号：EP05805030.3
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： AYALON-SOFFER, Michal , POLLOCK, Sarah , SHEMESH, Ronen , SOREK, Rotem , ZURIT, Levine , SHAQED, Zipi , TOPORIK, Amir , COJOCARU, Gad, S. , DAHARY, Dvir , KOL, Guy , AKIVA, Pinchas , NOVIK, Amit , NEMZER, Sergey , DIBER, Alexander , SHKLAR, Maxim , SELLA-TAVOR, Osnat , BAZAK, Lily , FARKASH, Arial , COHEN, Yossi
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6883
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
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10.发明公开METHODS OF IDENTIFYING PUTATIVE GENE PRODUCTS BY INTERSPECIES SEQUENCE COMPARISON AND BIOMOLECULAR SEQUENCES UNCOVERED THEREBY 审中-公开一种用于识别假定基因BY种间的序列比较和THAT DISCOVERED生物分子序列
公开(公告)号：EP1716227A2
公开(公告)日：2006-11-02
申请号：EP05703150.2
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： SOREK, Rotem , POLLOCK, Sarah , DIBER, Alex , LEVINE, Zurit , NEMZER, Sergey , KOL, Guy , WOOL, Assaf , HAVIV, Ami , COHEN, Yuval , COHEN, Yossi , SHEMESH, Ronen , SAVITSKY, Kinneret
IPC分类号： C12N1/00
CPC分类号： G06F19/22
摘要： A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced exons, thereby identifying the alternatively spliced exons.
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