公开(公告)号：EP0885230B1

公开(公告)日：2002-07-24

申请号：EP97905057.2

申请日：1997-02-19

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： MERLINI, Lucio ,  PENCO, Sergio ,  ZUNINO, Franco

IPC分类号： C07D491/22 ,  A61K31/435

CPC分类号： C07D491/22

摘要： Compounds of formula (I), wherein: R1 is -CN, -CH(CN)-R4, -CH=C(CN)-R4, -CH2-CH(CN)-R4, -C(=NOH)-NH2, -C(=NH)-NH2, -CH=C(NO2)-R4, -CH(CN)-R5, -CH(CH2NO2)-R5; 5-tetrazolyl, 2-(4,5-dihydrooxazolyl), 1,2,4-oxadiazolin-3-yl-5-one; R2 is hydrogen; R3 is hydrogen, OR6; R4 is hydrogen, C1-C6 linear or branched alkyl, CN, COOR7; R5 is hydrogen, OR8; R6 is hydrogen, C1-C6 linear or branched alkyl, (C6-C12) aryl (C1-C4) alkyl, (C1-C4) alkoxy (C1-C4) alkyl, (C1-C4) alkyl (C6-C12) aryl, (C6-C12) aryl (C2-C4) acyl, (C2-C4) acyl, amino (C1-C4) alkyl, amino (C2-C4) acyl, glycosyl; R7 is hydrogen, C1-C6 linear or branched alkyl, (C6-C12) aryl (C1-C4) alkyl, (C1-C4) alkoxy (C1-C4) alkyl, (C1-C4) alkyl (C6-C12) aryl; R8 has the same meanings of R6, independently of the latter. These compounds are active as topoisomerase I inhibitors and can be used as antitumor drugs.

公开(公告)号：EP0623351B1

公开(公告)日：1999-06-23

申请号：EP94106642.5

申请日：1994-04-28

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Ghione, Mario ,  Balsari, Andrea ,  Colnaghi, Maria Ines ,  Menard, Sylvie

IPC分类号： A61K39/395

CPC分类号： A61K31/70 ,  A61K8/14 ,  A61K8/64 ,  A61K9/127 ,  A61K38/00 ,  A61K39/395 ,  A61Q7/00 ,  B82Y5/00 ,  C07K16/44 ,  A61K2300/00

公开(公告)号：EP0698096B1

公开(公告)日：1997-03-26

申请号：EP94917613.5

申请日：1994-05-10

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： GRECO, Angela ,  PIEROTTI, Marco, A.

IPC分类号： C12N15/12 ,  C12N5/10 ,  G01N33/50

CPC分类号： C07K14/71

摘要： The present invention provides an in vitro cell culture system, based on neuronal cells comprising oncogenic derivatives of the NGF-receptor gene NTRK1, and exhibiting NGF-independent neuronal differentiation closely resembling NGF-induced cellular responses in normal cells, but differing from these responses by displaying cellular degeneration after prolonged culture periods. The present invention furthermore provides eukaryotic expression vectors containing cDNAs coding for the NTRK1-derived oncoprotein TRK-T1, and a method to obtain said neuronal cells by transformation with eukaryotic expression vectors coding for oncogenic derivatives of NTRK1.

公开(公告)号：EP0439048B1

公开(公告)日：1996-01-03

申请号：EP91100426.5

申请日：1991-01-16

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Balsari, Andrea ,  Colnaghi, Maria Ines ,  Ghione, Mario

IPC分类号： C12P21/08

CPC分类号： C07K16/44

公开(公告)号：EP0439048A3

公开(公告)日：1991-09-11

申请号：EP91100426.5

申请日：1991-01-16

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Balsari, Andrea ,  Colnaghi, Maria Ines ,  Ghione, Mario

IPC分类号： C12P21/08 ,  C12N5/20

CPC分类号： C07K16/44

摘要： A monoclonal antibody against Doxorubicin and other anthracycline derivatives, being said monoclonal antibody able to selectively recognize epitopes located in correspondence or in proximity of the aromatic D ring of the anthracycline molecule, is described.

公开(公告)号：EP1511752B3

公开(公告)日：2010-03-10

申请号：EP03730480.5

申请日：2003-05-28

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： MARZI, Mauro ,  MARASTONI, Elena ,  PENCO, Sergio ,  PISANO, Claudio ,  TINTI, Maria O. ,  VESCI, Loredana ,  ZUNINO, Franco ,  VERGANI, Domenico ,  DANELLI, Tamara ,  CABRI, Walter ,  ALPEGIANI, Marco ,  PATRICIO, Martin Gomez

IPC分类号： C07D491/22 ,  C07D471/14 ,  A61K31/47

CPC分类号： C07D491/22

摘要： Compounds of formula (I) or (II) are described: where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.

公开(公告)号：EP2061813A1

公开(公告)日：2009-05-27

申请号：EP07802280.3

申请日：2007-09-12

申请人： Dompe PHA.R.MA S.p.A. ,  Istituto Nazionale Per Lo Studio E La Cura Dei Tumori

发明人： MARTIN, Franck ,  CATTOZZO, Margherita ,  MAURIZI, Giovanni ,  DI CIOCCIO, Vito ,  FIGINI, Mariangela ,  CANEVARI, Silvana

IPC分类号： C07K16/30

CPC分类号： C07K16/3069 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/92

摘要： Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRα), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences : - RASESVSFLGINLIH (SEQ ID NO: 3), - QASNKDT (SEQ ID NO: 4), - LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region.

摘要翻译： 抗体或其片段，其特异性结合叶酸受体-α（FR±），worin所述抗体或其片段包含轻链谁的可变区包括至少一个下列的氨基酸序列组成： - RASESVSFLGINLIH（SEQ ID NO：3 ） - （QASNKDT SEQ ID NO：4）， - LQSKNFPPYT（SEQ ID NO：5），和worin所述轻链的恒定区是κ恒定区。

公开(公告)号：EP1719775B1

公开(公告)日：2008-08-06

申请号：EP06116366.3

申请日：2003-05-28

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Marzi, Mauro ,  Marastoni, Elena ,  Penco, Sergio ,  Pisano, Claudio SIGMA-TAU Inds.Far,a Riunite S.p.A ,  Tinti, Maria Ornella ,  Vesci, Loredana ,  Zunino, Franco ,  Vergani, Domenico SIGMA-TAU Inds.Farma.Riunite ,  Cabri, Walter ,  Alpegiani, Marco ,  Patricio, Martin ,  Danelli, Tamara SIGMA-TAU Inds.Farma Riunite S.p.A

IPC分类号： C07D491/22 ,  C07D471/14 ,  A61K31/47 ,  C07D307/00 ,  C07D221/00 ,  C07D209/00 ,  C07D313/00

CPC分类号： C07D491/22

公开(公告)号：EP1900752A1

公开(公告)日：2008-03-19

申请号：EP06019399.2

申请日：2006-09-15

申请人： DOMPE' pha.r.ma S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Martin, Franck ,  Cattozzo, Margherita ,  Maurizi, Giovanni ,  Di Cioccio, Vito ,  Figini, Mariangela ,  Canevari, Silvana

IPC分类号： C07K16/28 ,  C07K16/30

CPC分类号： C07K16/3069 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/92

摘要： Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRα), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences :
- RASESVSFLGINLIH (SEQ ID NO: 3),
- QASNKDT (SEQ ID NO: 4),
- LQSKNFPPYT (SEQ ID NO: 5),
and wherein the constant region of said light chain is a kappa constant region.

摘要翻译： 其特异性结合叶酸受体-α（FR±）的抗体或其片段，其中所述抗体或其片段包含轻链，其可变区包含以下氨基酸序列中的至少一个： - RASESVSFLGINLIH（SEQ ID NO：3 ）， - QASNKDT（SEQ ID NO：4）， - LQSKNFPPYT（SEQ ID NO：5），并且其中所述轻链的恒定区是κ恒定区。

公开(公告)号：EP1044977A1

公开(公告)日：2000-10-18

申请号：EP99830124.6

申请日：1999-03-09

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Penco, Sergio

IPC分类号： C07D491/22 ,  A61K31/435

CPC分类号： C07D491/22

摘要： Derivatives of camptothecin of formula (I)
wherein the groups R 1 , R 2 and R 3 are as defined in the description are disclosed.
The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index.
Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors are also disclosed.

摘要翻译： 式（I）喜树碱的衍生物其中基团R 1，R 2和R 3如说明书中所定义。 式（I）化合物具有抗肿瘤活性，显示出良好的治疗指标。 还公开了制备式（I）化合物及其在制备可用于治疗肿瘤的药物中的用途的方法。