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1.发明授权CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES 有权骑自行车，CXCR4受体结合肽和相关的中位数和诊断用途
公开(公告)号：EP2528936B9
公开(公告)日：2014-12-31
申请号：EP11710271.5
申请日：2011-01-20
申请人： Consiglio Nazionale Delle Ricerche , IRCCS- Istituto Nazionale Per Lo Studio E La Cura Dei Tumori "Fondazione Giovanni Pascale"
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公开(公告)号：EP2112154B1
公开(公告)日：2013-07-24
申请号：EP09162737.2
申请日：2003-05-28
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
发明人： Marzi, Mauro , Alloatti, Domenico , Pisano, Claudio , Tinti, Maria Ornella , Vesci, Loredana , Zunino, Franco
IPC分类号： C07D491/22 , A61K31/4375 , A61P35/00 , A61P31/12 , A61P33/00
CPC分类号： C07D491/22
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公开(公告)号：EP1509529B1
公开(公告)日：2009-08-12
申请号：EP03730481.3
申请日：2003-05-28
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
发明人： MARZI, Mauro Sigma-Tau Ind. Farmaceutiche Riunite , ALLOATTI, Domenico Sigma-Tau Ind. Farmac. Riunite , PISANO, Claudio Sigma-Tau Ind. Farmac. Riunite , TINTI, Maria Ornella Sigma-Tau Ind. Farmac. Riunit , VESCI, Loredana Sigma-Tau Ind. Farmac. Riunite SPA , ZUNINO, Franco Ist.N. per lo Studio e la Cura Tumo
IPC分类号： C07D491/22 , A61K31/4375 , A61P35/00 , A61P31/12 , A61P33/00
CPC分类号： C07D491/22
摘要： Formula (I) compounds are described: (I) where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.
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公开(公告)号：EP1576187A1
公开(公告)日：2005-09-21
申请号：EP03785912.1
申请日：2003-12-22
发明人： SOZZI, Gabriella
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6818 , C12Q1/6851 , C12Q2600/118
摘要： A method for the early diagnosis, prognosis or clinical monitoring of cancer disease based on the quantitation of DNA in a plasma sample from a cancer patient, a subject with cancer susceptibility or an individual at risk of developing cancer.
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5.发明公开USE OF 4'-IODO-4'-DEOXYDOXORUBICIN FOR THE TREATMENT OF AMYLOIDOSIS 失效4'-IODO-4'-DEOXYDOXORRININ在治疗淀粉样病变中的应用
公开(公告)号：EP0663832A1
公开(公告)日：1995-07-26
申请号：EP94924299.0
申请日：1994-07-29
申请人： POLICLINICO SAN MATTEO, ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO DI DIRITTO PUBBLICO , ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
发明人： MERLINI, Giampaolo , GIANNI, Luca
CPC分类号： A61K31/70 , Y10S514/908
摘要： The use of 4'-iodo-4'-deoxydoxorubicin and its pharmaceutically acceptable salts in the treatment of amyloidosis is described.
摘要翻译： 描述了4'-碘-4'-脱氧多柔比星及其药学上可接受的盐在治疗淀粉样变性病中的用途。
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6.发明授权
公开(公告)号：EP0231005B1
公开(公告)日：1992-12-30
申请号：EP87101016.1
申请日：1987-01-24
发明人： Silvestrini, Rosella
IPC分类号： C12Q1/06
CPC分类号： C12Q1/06 , G01N33/5005 , Y10S435/81
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公开(公告)号：EP0316776A3
公开(公告)日：1991-05-22
申请号：EP88118771.0
申请日：1988-11-11
摘要： Monoclonal antibodies able to selectively bind to doxorubicin and its analogues and derivatives are disclosed.
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公开(公告)号：EP0316776A2
公开(公告)日：1989-05-24
申请号：EP88118771.0
申请日：1988-11-11
摘要： Monoclonal antibodies able to selectively bind to doxorubicin and its analogues and derivatives are disclosed.
摘要翻译： 公开了能够选择性结合多柔比星及其类似物和衍生物的单克隆抗体。
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9.发明公开CYCLIC PEPTIDES BINDING CXCR4 RECEPTOR AND RELATIVE MEDICAL AND DIAGNOSTIC USES 有权骑自行车，CXCR4受体结合肽和相关的中位数和诊断用途
公开(公告)号：EP2528936A1
公开(公告)日：2012-12-05
申请号：EP11710271.5
申请日：2011-01-20
申请人： Consiglio Nazionale Delle Ricerche , IRCCS- Istituto Nazionale Per Lo Studio E La Cura Dei Tumori "Fondazione Giovanni Pascale"
发明人： AMODEO, Pietro , VITALE, Rosamaria , DE LUCA, Stefania , SCALA, Stefania , CASTELLO, Giuseppe , SIANI, Alfredo
IPC分类号： C07K7/06
摘要： The present invention relates to the identification of new peptides and peptidomimetics which bind the CXCR4 receptor, capable of forming complexes with receptors for chemokines, in particular with CXCR4. The invention also relates to the use of these peptides for the treatment, prevention and diagnosis of diseases which involve chemokine receptors (i.e. neoplasias, metastases, HIV-I virus infections), and also the mobilization of stem cells of hemopoietic precursors in the case of autologous transplants. Finally, the invention comprises pharmaceutical compositions and diagnostic kits comprising said peptides.
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10.发明公开BROAD-SPECTRUM ANTI-CANCER TREATMENT BASED ON IMINOCAMPTOTHECIN DERIVATIVES 审中-公开基于IMINOCAMPTOTHECINDERIVATEN用行动范围广癌症治疗
公开(公告)号：EP2120948A1
公开(公告)日：2009-11-25
申请号：EP08707589.1
申请日：2008-02-07
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
发明人： PISANO, Claudio , VESCI, Loredana , ZUNINO, Franco
IPC分类号： A61K31/4745 , A61P35/00
CPC分类号： A61K31/4745
摘要： A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of a cancer or tumor pathology selected from the group consisting of head and neck carcinoma, pancreas carcinoma, melanoma, bladder carcinoma, mesothelioma and epidermoid skin carcinoma.
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