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公开(公告)号：EP2698383A1
公开(公告)日：2014-02-19
申请号：EP12180486.8
申请日：2012-08-14
发明人： Fitzgerald, Stephen Peter , Innocenzi, Paul John , McConnell, Ivan Robert , Lowry, Philip Andrew , Benchikh, Elouard
CPC分类号： C07K16/44 , C07K2317/33 , C07K2317/92 , G01N33/948
摘要： The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the CP family. Unique antibodies derived from immunogens enable said methods and kits.
摘要翻译： 本发明描述了用于从CP家族中检测和确定当前和未来合成大麻素的方法和试剂盒。 来源于免疫原的独特抗体能够实现所述方法和试剂盒。
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公开(公告)号：EP2631231A1
公开(公告)日：2013-08-28
申请号：EP13156414.8
申请日：2013-02-22
IPC分类号： C07D295/096 , C07D295/155
CPC分类号： C07D295/155 , C07D241/04 , C07D295/096 , C07K14/47 , C07K14/765 , C07K16/44 , C07K2317/76 , G01N33/5308
摘要： The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity.
摘要翻译： 本发明描述了新型免疫原，其用于生产具有独特结合特性的新型抗体，因为它们与各种苯基哌嗪衍生物交叉反应。 这些抗体使得方法和试剂盒能够在体外样品中检测和/或测定苯基哌嗪衍生物（例如mCPP，TFMPP和MeOPP），这在成本，易用性，速度和灵敏度方面优于目前可用的分析方法。
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公开(公告)号：EP2418492A1
公开(公告)日：2012-02-15
申请号：EP10172415.1
申请日：2010-08-10
CPC分类号： G01N33/948 , C07K16/44
摘要： Carisoprodol is a centrally-acting prescription drug of known abuse. Upon ingestion it is rapidly metabolised to meprobamate, also a prescription drug with abuse potential. Current immunoassays are specific for carisoprodol and therefore have a short window of detection and, furthermore, are ineffective at detecting meprobamate. The current invention, underpinned by an antibody specific for meprobamate, overcomes these deficiencies.
摘要翻译： Carisoprodol是一种中枢作用的已知滥用药物。 摄入后，它迅速代谢为甲基磺酸盐，也是具有滥用潜力的处方药。 目前的免疫测定法是特异性的，因此，对于二十二烷酮，因此具有短的检测窗口，此外，在检测甲基磺酸盐时无效。 由针对甲基磺酸盐的抗体支持的本发明克服了这些缺点。
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公开(公告)号：EP2402761A1
公开(公告)日：2012-01-04
申请号：EP10168015.5
申请日：2010-06-30
CPC分类号： G01N33/948 , C07K16/44 , C07K2317/33
摘要： The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific for the chloral hydrate metabolite trichloroethanol glucuronide. Detection and quantification of trichloroethanol glucuronide has important applications in clinical toxicology, drug facilitated crime, water testing and solvent exposure.
摘要翻译： 本发明涉及用于间接检测水合氯醛的免疫测定方法和试剂盒。 本发明由新型免疫原支持，该新型免疫原产生对水合氯醛代谢物三氯乙醇葡萄糖醛酸苷特异的抗体。 三氯乙醇葡萄糖醛酸苷的检测和定量在临床毒理学，药物促进的犯罪，水测试和溶剂暴露方面具有重要应用。
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公开(公告)号：EP2246703A1
公开(公告)日：2010-11-03
申请号：EP09159094.3
申请日：2009-04-29
CPC分类号： G01N33/94 , C07K16/16 , G01N33/946
摘要： The present invention describes the first immunoassay methods and kits for detecting or determining salvinorin A, its analogues and metabolites. Also described are antibodies for use in the immunoassay methods and kits for the detection and / or determination of salvinorin A, its analogues and metabolites..
摘要翻译： 本发明描述了用于检测或测定盐菌素A及其类似物和代谢物的第一种免疫测定方法和试剂盒。 还描述了用于检测和/或测定salvinorin A及其类似物和代谢物的免疫测定方法和试剂盒中的抗体。
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公开(公告)号：EP1988398B1
公开(公告)日：2009-12-16
申请号：EP07075322.3
申请日：2007-05-02
IPC分类号： G01N33/94 , C07C217/74
CPC分类号： G01N33/9486
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公开(公告)号：EP3002291B1
公开(公告)日：2019-08-07
申请号：EP15186902.1
申请日：2015-09-25
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48.发明授权
公开(公告)号：EP2950103B1
公开(公告)日：2018-10-17
申请号：EP15168737.3
申请日：2015-05-21
IPC分类号： G01N33/94
CPC分类号： G01N33/948 , A61K39/385 , C07D231/56 , C07K16/44 , C07K2317/30 , C07K2317/33 , C07K2317/92
摘要： An immunoassay method for detecting and determining adamantane substituted indazole and indole synthetic cannabinoids is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies.
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公开(公告)号：EP3366706A1
公开(公告)日：2018-08-29
申请号：EP18158077.0
申请日：2018-02-22
摘要： Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[2-(dimethylamino)cylohexyl]-N-methylbenzamide and 3,4,-dichloro-N-[2-(methylamino)cylohexyl]-N-methylbenzamide, as well as the precursory immunogens, are described.
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公开(公告)号：EP2716659B1
公开(公告)日：2018-08-29
申请号：EP13187592.4
申请日：2013-10-07
IPC分类号： C07K16/44 , A61K31/485 , G01N33/94 , A61K47/64
CPC分类号： G01N33/94 , A61K47/643 , A61K47/646 , C07K16/44 , C07K2317/33
摘要： Haptens and immunogens for the preparation of novel monoclonal antibodies, which detect the synthetic opioid meperidine and its active metabolite normeperidine. These antibodies enable methods and kits, which are useful in an immunoassay for therapeutic drug monitoring (TDM) and in extending the window of detection for cases of abuse and drug-facilitated sexual assault (DFSA).
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