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公开(公告)号：EP2672999A2
公开(公告)日：2013-12-18
申请号：EP12704250.5
申请日：2012-02-07
申请人： Roche Glycart AG
发明人： GERDES, Christian , KLEIN, Christian , MOESSNER, Ekkehard , NICOLINI, Valeria G. , UMANA, Pablo
CPC分类号： C07K16/32 , A61K38/00 , A61K38/2013 , A61K45/06 , A61K47/6813 , C07K14/52 , C07K19/00 , C07K2319/33 , A61K2300/00
摘要： The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.
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公开(公告)号：EP2483310A1
公开(公告)日：2012-08-08
申请号：EP10757604.3
申请日：2010-09-27
申请人： Roche Glycart AG
发明人： BRUENKER, Peter , FERRARA KOLLER, Claudia , GRAU, Sandra , HERTER, Sylvia , LAMPERT, Christoph , MOESSNER, Ekkehard , UMANA, Pablo , WALDHAUER, Inja
CPC分类号： C07K16/2878 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP2467165A2
公开(公告)日：2012-06-27
申请号：EP10744911.8
申请日：2010-08-13
申请人： Roche Glycart AG
CPC分类号： C07K16/00 , A61K47/48423 , A61K47/48538 , A61K47/48646 , A61K47/6813 , A61K47/6843 , A61K47/6871 , A61K2039/505 , C07K16/18 , C07K16/40 , C07K16/468 , C07K2317/73 , C07K2317/74 , C07K2317/92
摘要： The present invention relates to immunoconjugates. In particular embodiments, the present invention relates to immunoconjugates comprising at least one single-chain effector moiety and two or more antigen binding moieties. In addition, the present invention relates to nucleic acid molecules encoding such immunoconjugates, vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
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公开(公告)号：EP3708584A1
公开(公告)日：2020-09-16
申请号：EP19217855.6
申请日：2014-02-24
申请人： Roche Glycart AG
发明人： BACAC, Marina , HOFER, Thomas , HOSSE, Ralf , NEUMANN, Christiane , KLEIN, Christian , MOESSNER, Ekkehard , UMAÑA, Pablo , WEINZIERL, Tina
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP2961771B1
公开(公告)日：2020-01-01
申请号：EP14708507.0
申请日：2014-02-24
申请人： Roche Glycart AG
发明人： BACAC, Marina , HOFER, Thomas , HOSSE, Ralf , NEUMANN, Christiane , KLEIN, Christian , MOESSNER, Ekkehard , UMANA, Pablo , WEINZIERL, Tina
IPC分类号： A61K39/00 , C07K16/28 , C07K16/30 , A61K39/395 , A61P35/00
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46.发明授权
公开(公告)号：EP2981552B1
公开(公告)日：2019-02-13
申请号：EP14714275.6
申请日：2014-04-01
申请人： Roche Glycart AG
发明人： BRUENKER, Peter , DAOUTI, Sherif , FENG, Ningping , FERRARA KOLLER, Claudia , GEORGES, Guy , GRAU-RICHARDS, Sandra , HOSSE, Ralf , KLEIN, Christian , KOENIG, Maximiliane , MOELLEKEN, Joerg , MOESSNER, Ekkehard , NIU, Huifeng , PACKMAN, Kathryn E. , RUNZA, Valeria , SEEBER, Stefan , UMANA, Pablo , WALDHAUER, Inja , WANG, Huisheng , WEISER, Barbara
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47.发明授权
公开(公告)号：EP2414391B1
公开(公告)日：2018-11-28
申请号：EP10711847.3
申请日：2010-03-30
申请人： Roche Glycart AG
发明人： BRINKMANN, Ulrich , BRUENKER, Peter , CROASDALE-WOOD, Rebecca , KLEIN, Christian , KOPETZKI, Erhard , MOESSNER, Ekkehard , REGULA, Joerg Thomas , SCHANZER, Juergen Michael , STRACKE, Jan Olaf , UMANA, Pablo
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
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公开(公告)号：EP2702074B1
公开(公告)日：2018-11-21
申请号：EP12717674.1
申请日：2012-04-26
申请人： Roche Glycart AG
发明人： AST, Oliver , BRUENKER, Peter , HOFER, Thomas U. , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , UMANA, Pablo
IPC分类号： C07K16/28 , C07K16/30 , C07K16/40 , A61K39/00 , A61K38/20 , A61K47/68 , C07K14/52 , C07K14/55 , C07K14/54 , A61K39/395 , C07K16/46 , C07K16/18
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
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公开(公告)号：EP2882775B1
公开(公告)日：2018-02-14
申请号：EP13745419.5
申请日：2013-08-06
申请人： Roche Glycart AG
发明人： HOFER, Thomas , JI, Changhua , MOESSNER, Ekkehard , UMANA, Pablo
CPC分类号： C07K16/2851 , A61K2039/505 , C07K14/56 , C07K2317/33 , C07K2317/52 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/92 , C07K2319/00 , C07K2319/01
摘要： The present invention generally relates to antibodies specific for asialoglycoprotein receptor (ASGPR) and their use for selectively delivering effector moieties that influence cellular activity. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies of the invention, and to methods of using them in the treatment of disease.
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50.发明授权
公开(公告)号：EP2473532B1
公开(公告)日：2017-06-21
申请号：EP10745651.9
申请日：2010-08-27
申请人： Roche Glycart AG
IPC分类号： C07K16/30
CPC分类号： C07K16/3007 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/92
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