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公开(公告)号：EP2016045B1
公开(公告)日：2014-10-29
申请号：EP07776245.8
申请日：2007-04-24
IPC分类号： C07C237/26 , C07C231/24
CPC分类号： C07C237/26
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42.发明公开SUNITINIB HEMI-L-MALATE, POLYMORPHS AND PREPARATION THEREOF, POLYMORPHS OF RACEMIC SUNITINIB MALATE, COMPOSITINS CONTAINING SUNITINIB BASE AND MALIC ACID AND PREPARATION THEREOF 审中-公开舒尼替尼半L-苍鹭，多晶型物及其生产多晶型外消旋舒尼替尼苍鹭，舒尼替尼碱和苹果酸组合物及其制备
公开(公告)号：EP2220071A2
公开(公告)日：2010-08-25
申请号：EP08851719.8
申请日：2008-11-21
发明人： JEGOROV, Alexandr , VRASPIR, Pavel , ARONHIME, Judith , GAVENDA, Ales , ANGIOLETTI, Paolo , MACDONALD,Peter, Lindsay , SCARPITTA, Francesca , VILLA, Marco , BIGATTI, Ettore , CANAVESI, Augusto
IPC分类号： C07D403/06 , A61K31/404 , A61P35/00
CPC分类号： C07D403/06
摘要： The invention provides Sunitinib hemi-L-malate, polymorphs thereof, polymorphs of racemic sunitinib malate, compositions containing sunitinib base and either L or racemic malic acid, processes for the preparation thereof, and pharmaceutical compositions thereof.
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公开(公告)号：EP2016045A2
公开(公告)日：2009-01-21
申请号：EP07776245.8
申请日：2007-04-24
IPC分类号： C07C237/26 , C07C231/24
CPC分类号： C07C237/26
摘要： The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof.
摘要翻译： 本发明涉及固体结晶替加环素及其结晶形式。
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公开(公告)号：EP1771414A1
公开(公告)日：2007-04-11
申请号：EP06737531.1
申请日：2006-03-08
IPC分类号： C07D209/14 , A61K31/404 , A61P1/00
CPC分类号： C07D209/14
摘要： Provided are amorphous and purely amorphous tegaserod maleate and processes for the preparation thereof. Also provided are pharmaceutical compositions comprising amorphous or purely amorphous tegaserod maleate and methods for the treatment of irritable bowel syndrome using the same. (I)
摘要翻译： 提供无定形和纯无定形的替加色罗马来酸盐及其制备方法。 还提供了包含无定形或纯无定形替加色罗马来酸盐的药物组合物以及使用该组合物治疗肠易激综合征的方法。 （一世）
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45.发明公开
公开(公告)号：EP1713489A2
公开(公告)日：2006-10-25
申请号：EP05791142.2
申请日：2005-08-23
IPC分类号： A61K31/663 , A61P19/10 , C07F9/38
CPC分类号： C07F9/3873
摘要： The present invention relates to solid amorphous and crystalline forms of ibandronate sodium.
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公开(公告)号：EP1633364A2
公开(公告)日：2006-03-15
申请号：EP05705020.5
申请日：2005-01-05
IPC分类号： A61K31/519 , A61P15/10 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04
摘要： Provided are processes for the preparation of sildenafil base and the citrate salt sildenafil. Also provided are sildenafil citrate water adduct and a method of preparing pharmaceutical compositions comprising combining the sildenafil citrate and/or sildenafil citrate water adduct with at least one pharmaceutically-acceptable excipient.
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公开(公告)号：EP1613598A2
公开(公告)日：2006-01-11
申请号：EP04815093.2
申请日：2004-12-16
发明人： ARONHIME, Judith , DOLITZKY, Ben-Zion , LUVCHICK, Eran , HILDESHEIM, Jean , EISEN-NEVO, Hagit , IZSAK, Reuven
IPC分类号： C07D215/22
CPC分类号： C07D215/227 , A61K31/496
摘要： The invention encompasses aripiprazole crystalline forms, methods of preparing the same, and pharmaceutical compositions having aripiprazole crystalline forms.
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48.发明授权ETHANOLATE OF AZITHROMYCIN, PROCESS FOR MANUFACTURE, AND PHARMACEUTICAL COMPOSITIONS THEREOF 有权阿奇霉素，HERSTLLUNGSVERFAHREN和乙醇及其药物组合物
公开(公告)号：EP1152765B1
公开(公告)日：2004-10-13
申请号：EP99965069.0
申请日：1999-11-30
发明人： SINGER, Claude , ARONHIME, Judith
摘要： A novel, non-hygroscopic form of azithromycin is disclosed, as well as a method for preparing it by the gradual crystallization of azithromycin from ethanol by the addition of a minimal amount of water to effect crystal formation. Pharmaceutical compositions containing this novel form of azithromycin are also disclosed.
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公开(公告)号：EP1453509A2
公开(公告)日：2004-09-08
申请号：EP02792238.4
申请日：2002-11-08
IPC分类号： A61K31/445 , C07D211/14
CPC分类号： C07D211/22
摘要： The present invention provides novel crystal forms of fexofenadine base and processes for their preparation. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.
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50.发明公开
公开(公告)号：EP1390355A2
公开(公告)日：2004-02-25
申请号：EP02706471.6
申请日：2002-02-27
发明人： GARTI, Nissim , BERKOVICH, Yana , DOLITZKY, Ben-Zion , ARONHIME, Judith , SINGER, Claude , LIEBERMAN, Anita , GERSHON, Neomi
IPC分类号： C07D253/075
CPC分类号： C07D253/075
摘要： The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.
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