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    COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY
    44.
    发明公开
    COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY 审中-公开
    组合类固醇和糖皮质激素受体拮抗剂治疗

    公开(公告)号：EP2661175A1

    公开(公告)日：2013-11-13

    申请号：EP12732354.1

    申请日：2012-01-06

    申请人： Corcept Therapeutics, Inc.

    发明人： BELANOFF, Joe ,  LOCKEY, Peter

    IPC分类号： A01N43/42 ,  A61K31/44

    CPC分类号： A61K31/437 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides compositions of an anti-inflammatory glucocorticosteroid and a glucocorticoid receptor (GR) modulator useful for inhibiting glucocorticoid receptor induced transactivation without substantially inhibiting glucocorticoid receptor induced transrepression. Also provided are methods of treating a disorder or condition and reducing the side effects of glucocorticosteroid treatment, using the compositions of the present invention.

    摘要翻译： 本发明提供了用于抑制糖皮质激素受体诱导的反式激活而基本上不抑制糖皮质激素受体诱导的反式抑制的抗炎糖皮质激素和糖皮质激素受体（GR）调节剂的组合物。 还提供了使用本发明的组合物治疗障碍或病症并减轻糖皮质激素治疗的副作用的方法。

    METHODS FOR TREATING STRESS DISORDERS USING GLUCOCORTICOID RECEPTOR-SPECIFIC ANTAGONISTS
    49.
    发明授权
    METHODS FOR TREATING STRESS DISORDERS USING GLUCOCORTICOID RECEPTOR-SPECIFIC ANTAGONISTS 有权
    法与压力有关的疾病的治疗中使用糖皮质激素REZEPTO特异性拮抗剂

    公开(公告)号：EP1370268B1

    公开(公告)日：2009-07-15

    申请号：EP02725270.9

    申请日：2002-03-19

    申请人： Corcept Therapeutics, Inc.

    发明人： BELANOFF, Joseph, K.

    IPC分类号： A61K31/59 ,  A61K31/56 ,  A61P25/18

    CPC分类号： A61K31/59 ,  A61K31/56 ,  A61K31/57

    摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating stress disorders. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating stress disorders in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME
    50.
    发明授权
    METHODS FOR INHIBITING COGNITIVE DETERIORATION IN ADULTS WITH DOWN'S SYNDROME 有权
    一种抑制效率的认知功能减退的成年人患有唐氏综合症

    公开(公告)号：EP1432379B1

    公开(公告)日：2008-10-15

    申请号：EP02770441.0

    申请日：2002-08-27

    申请人： Corcept Therapeutics, Inc.

    发明人： BELANOFF, Joseph, K.

    IPC分类号： A61K31/00 ,  A61K31/569 ,  A61K31/573 ,  A61K31/05 ,  A61P25/28

    CPC分类号： A61K31/573 ,  A61K31/56 ,  A61K31/567 ,  A61K31/575

    摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can be used in methods for preventing or reversing cognitive deterioration in adults with Down's syndrome. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for preventing or reversing cognitive deterioration in a DS patient including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.