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41.发明公开
公开(公告)号：EP2406675A1
公开(公告)日：2012-01-18
申请号：EP10720310.1
申请日：2010-03-12
CPC分类号： G02B6/4292 , G02B6/3821 , G02B6/3853 , G02B6/389 , G02B6/3893 , G02B6/40 , G02B6/4204 , G02B6/4226
摘要： A connector to connect a fiber bundle probe to a light injection module including a tightening cam having an opening of a specified shape adapted to receive the fiber bundle probe, a cam driving coupled to the tightening cam, wherein the tightening cam is configured to translate in response to rotation of the cam driving until the tightening cam is blocked, at least one spring extending between the tightening cam and the cam driving, wherein the at least one spring is configured to resist when the cam driving is actuated by rotation and the tightening cam is blocked, and a locking mechanism to lock the cam driving into a selected position.
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42.发明授权
公开(公告)号：EP1523270B1
公开(公告)日：2010-05-19
申请号：EP03755595.0
申请日：2003-07-11
CPC分类号： H04N1/0281 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0084 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/0072 , G02B21/0076 , G02B21/0084 , G02B23/26 , G02B26/101
摘要： The invention concerns a method using an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of said guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by said fiber, then detected and digitized to form an image element. According to a first aspect of the invention, the method provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. According to a second aspect, the method provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface. The invention is characterized in that the method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The invention enables in vivo, in situ and real time imaging.
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43.发明公开
公开(公告)号：EP2024774A1
公开(公告)日：2009-02-18
申请号：EP07731440.9
申请日：2007-05-11
发明人： LACOMBE, François , VIELLEROBE, Bertrand , BOULAROT, Nicolas , DOUSSOUX, François , PERCHANT, Aymeric
CPC分类号： G02B23/26 , A61B1/00165 , A61B1/043 , A61B1/313 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G02B6/06
摘要： The present invention relates to an endoscopy device comprising several light guides (1, 2, 3), each light guide comprising one or more optical fibres. The light guides are coupled with a sweeping system (4) arranged to direct an excitation light beam in alternation in one of the fibres of the guides from the proximal end of the guide comprising said one of the fibres. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal (10) under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.
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公开(公告)号：EP2005143A1
公开(公告)日：2008-12-24
申请号：EP07731179.3
申请日：2007-03-23
发明人： ABRAT, Benjamin , CAVE, Charlotte , LOISEAU, Alexandre , LOPEZ, Jérôme , OSDOIT, Anne , VIELLEROBE, Bertrand
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/07 , A61B5/0068 , A61B5/0084 , G01N21/6428 , G01N21/6458 , G01N2021/6484
摘要： The invention relates to a method for the acquisition of in-vivo fluorescence imaging from a fabric using an acquisition system that includes at least one optical fibre exciting the fabric by scanning light beam. According to the invention, the system is used to detect fluorescence signals emitted by the Methylene Blue present in the fabric.
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">45.发明公开PROCEDE ET SYSTEME D"IMAGERIE MICROSCOPIQUE DE FLUORESCENCE FIBREE MULTIMARQUAGE 有权荧光显微图像系统和方法纤维和多打标
公开(公告)号：EP1766373A1
公开(公告)日：2007-03-28
申请号：EP05777324.4
申请日：2005-06-09
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6417 , G01N2021/6423
摘要： The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophors contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophors. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.
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46.发明公开
公开(公告)号：EP1523270A1
公开(公告)日：2005-04-20
申请号：EP03755595.0
申请日：2003-07-11
CPC分类号： H04N1/0281 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0084 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/0072 , G02B21/0076 , G02B21/0084 , G02B23/26 , G02B26/101
摘要： The invention concerns a method using an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of said guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by said fiber, then detected and digitized to form an image element. According to a first aspect of the invention, the method provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. According to a second aspect, the method provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface. The invention is characterized in that the method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The invention enables in vivo, in situ and real time imaging.
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公开(公告)号：EP2725961B1
公开(公告)日：2020-09-02
申请号：EP12730914.4
申请日：2012-06-25
申请人： Université Pierre et Marie Curie (Paris 6) , Centre National de la Recherche Scientifique , Mauna Kea Technologies , Endocontrol
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48.发明授权
公开(公告)号：EP1523731B1
公开(公告)日：2018-06-27
申请号：EP03750802.5
申请日：2003-07-11
IPC分类号： G06T5/00
CPC分类号： G06T5/008 , G06T2207/10056
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公开(公告)号：EP2459101B8
公开(公告)日：2014-11-19
申请号：EP10768547.1
申请日：2010-07-19
CPC分类号： A61B5/0084 , A61B1/00154 , A61B1/313 , A61B5/0068 , A61B5/0071 , A61B5/6814 , A61B5/6864 , A61B5/6868 , A61B5/6882 , A61B90/11 , A61B2503/40 , A61B2560/063 , A61B2562/0238 , G02B23/26
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50.发明授权PROCEDE ET SYSTEME D'IMAGERIE MICROSCOPIQUE DE FLUORESCENCE FIBREE MULTIMARQUAGE 有权荧光显微图像系统和方法纤维和多打标
公开(公告)号：EP1766373B1
公开(公告)日：2013-01-02
申请号：EP05777324.4
申请日：2005-06-09
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6417 , G01N2021/6423
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