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56 条记录 (耗时 0.017 秒)

    NOVEL ALLERGEN
    44.
    发明公开
    NOVEL ALLERGEN 审中-公开
    中毒过敏

    公开(公告)号：EP3171890A1

    公开(公告)日：2017-05-31

    申请号：EP15750835.9

    申请日：2015-07-20

    申请人： Phadia AB

    发明人： MATTSSON, Lars ,  OLSSON, Ulrica ,  LUNDGREN, Thomas ,  LIDHOLM, Jonas ,  LARSSON, Håkan

    IPC分类号： A61K39/35

    CPC分类号： G01N33/6854 ,  C07K14/47

    摘要： The invention relates to a novel horse allergen consisting of a heterodimeric protein having a first peptide chain and a second peptide chain together having an overall sequence identity of at least 70% with the combined sequences of SEQ ID NO:3 and SEQ ID NO: 4, as well as a single chain protein having an overall sequence identity of at least 70%, such as 75%, 80%, 85%, 90%, 95%, or 98%, with the combined amino acid sequences according to SEQ ID NO: 3 and SEQ ID NO: 4. The invention further relates to the use of the protein in methods of diagnosis and therapy of Type I allergy, and kits and compositions for use in such methods.

    摘要翻译： 本发明涉及由具有第一肽链和第二肽链的异二聚体蛋白组成的新型马过敏原，其总序列同一性与SEQ ID NO：3和SEQ ID NO：4的组合序列具有至少70％的总体序列同一性 ，以及具有至少70％，例如75％，80％，85％，90％，95％或98％的总体序列同一性的单链蛋白，其中根据SEQ ID NO.3和SEQ ID NO：4。本发明还涉及该蛋白在诊断和治疗I型变态反应的方法中的用途，以及用于此类方法的试剂盒和组合物。

    PROGNOSTIC METHOD FOR INDIVIDUALS WITH PROSTATE CANCER
    46.
    发明公开
    PROGNOSTIC METHOD FOR INDIVIDUALS WITH PROSTATE CANCER 有权
    PROGNOSEVERFAHRENFÜRPERSONEN MIT PROSTATAKREBS

    公开(公告)号：EP2922970A1

    公开(公告)日：2015-09-30

    申请号：EP13799501.5

    申请日：2013-11-20

    申请人： Phadia AB

    发明人： GRÖNBERG, Henrik ,  EKLUND, Martin

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/24

    摘要： The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to forecast if it is likely that the prostate cancer patient will require active therapy like radiation therapy or surgery. A method based on a redundantly designed combination of data is disclosed for estimating if prostate cancer is aggressive or indolent. Said method combines SNP data to form a composite value, wherein at least 5% of the SNPs can be disregarded.

    摘要翻译： 本发明一般涉及各种形式的遗传标记物的检测和鉴定以及各种形式的蛋白质，其具有潜在的用途作为诊断标记。 通过确定患者样本中的多个生物标志物和遗传标记的水平，并根据预先确定的公式组合获得的值，可以预测前列腺癌患者是否可能需要诸如放射治疗或 手术。 公开了一种基于冗余设计的数据组合的方法，用于估计前列腺癌是否具有侵略性或惰性。 所述方法将SNP数据组合以形成复合值，其中至少5％的SNP可被忽略。

    METHOD, COMPUTER PROGRAM PRODUCT AND SYSTEM FOR ENABLING CLINICAL DECISION SUPPORT
    47.
    发明公开
    METHOD, COMPUTER PROGRAM PRODUCT AND SYSTEM FOR ENABLING CLINICAL DECISION SUPPORT 审中-公开
    方法，计算机程序产品和系统用于实现对临床决策支持

    公开(公告)号：EP2255308A4

    公开(公告)日：2015-07-22

    申请号：EP09708942

    申请日：2009-02-06

    申请人： PHADIA AB

    发明人： ÖNELL ANNICA ,  WALL KERSTIN ,  FORSGREN PETER ,  KOBER ANITA

    IPC分类号： G06F19/00 ,  G01N33/564 ,  G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/564 ,  G01N2800/52 ,  G01N2800/56 ,  G16H50/20

    摘要： A method enables clinical decision support based on test results for a plurality of tested biomarkers. The method is executed by a data reduction module (15) and comprises the steps of receiving the test results from a testing facility (11); accessing a predefined structure in which available biomarkers are associated with hosts, at least one host being associated with a plurality of biomarkers; identifying a set of hosts by mapping the tested biomarkers to the structure; assigning a host value to each host in said set of hosts based on the test results of the tested biomarker(s) mapped to the host; and providing input data indicative of the set of hosts and the assigned host values for input to a computer-based decision engine (13) for generating the clinical decision support (12). The data reduction module (15) may be included in a system and implemented by computer-executable instructions running on a data processing device, such as a PC or a web server.

    METHOD FOR INDICATING THE PRESENCE OR NON-PRESENCE OF PROSTATE CANCER
    48.
    发明公开
    METHOD FOR INDICATING THE PRESENCE OR NON-PRESENCE OF PROSTATE CANCER 审中-公开
    VERFAHREN ZUR ANZEIGE DES VORHANDENSEINS ODER NICHTVORHANDENSEINS VON PROSTATAKREBS

    公开(公告)号：EP2850432A2

    公开(公告)日：2015-03-25

    申请号：EP13727408.0

    申请日：2013-05-16

    申请人： Phadia AB

    发明人： GRÖNBERG, Henrik ,  EKLUND, Martin

    IPC分类号： G01N33/574 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57434 ,  G01N2333/96441

    摘要： The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to determine if it is likely that the patient suffers from prostate cancer.

    摘要翻译： 本发明一般涉及各种形式的遗传标记物的检测和鉴定，以及各种形式的蛋白质，其具有潜在的用途作为诊断标记。 通过确定患者样品中的多个生物标志物和遗传标记的水平，并且根据预定义的公式组合获得的值，可以确定患者是否可能患有前列腺癌。

    CALIBRATION REAGENT AND METHOD
    49.
    发明公开
    CALIBRATION REAGENT AND METHOD 有权
    校准试剂和方法

    公开(公告)号：EP2756312A1

    公开(公告)日：2014-07-23

    申请号：EP12775854.8

    申请日：2012-09-14

    申请人： Phadia AB

    发明人： ELFVERSON, Göran ,  MATSSON, Per ,  NYSTRAND, Mats

    IPC分类号： G01N33/68 ,  G01N33/96 ,  C07K16/00

    CPC分类号： G01N33/5302 ,  C07K16/00 ,  G01N33/6854 ,  G01N33/96

    摘要： The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilised, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilised on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent.

    摘要翻译： 本发明涉及一种用于校准多重测定的方法，包括：将校准试剂添加到其上固定有多种捕捉剂的固相，加入具有结合校准试剂的能力的检测分子，检测结合 从而产生校准曲线，其中所述校准试剂包含至少两种不同的结合分子，其中每种结合分子具有与固定在固相上的捕获剂特异性结合的能力和结合到检测分子的能力。 还提供了包含这种校准试剂的多重测定系统。