利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.011 秒)

    METHOD AND APPARATUS FOR MEASURING PROTEIN POST-TRANSLATIONAL MODIFICATION
    1.
    发明公开
    METHOD AND APPARATUS FOR MEASURING PROTEIN POST-TRANSLATIONAL MODIFICATION 审中-公开
    方法和设备测量翻译后的蛋白质修饰

    公开(公告)号：EP2201353A4

    公开(公告)日：2011-01-26

    申请号：EP08833371

    申请日：2008-09-26

    申请人： CALDERA PHARMACEUTICALS INC

    发明人： BIRNBAUM EVA R ,  WARNER BENJAMIN P ,  BALDWIN SHARON M ,  BERGER JENNIFER A ,  PETERSON-COURT LORI J ,  HARRIS MICHAEL N ,  MILLER REBECCA L E

    IPC分类号： G01N23/223 ,  G01N33/68

    CPC分类号： C12Q1/485 ,  C12Q1/37 ,  G01N21/75 ,  G01N23/223 ,  G01N33/20 ,  G01N33/6842 ,  G01N2223/076 ,  G01N2333/91215 ,  G01N2333/96441 ,  Y10T436/17 ,  Y10T436/200833

    摘要： The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

    PROSTASIN PARTIAL PEPTIDE AND ANTI-PROSTASIN ANTIBODY
    2.
    发明公开
    PROSTASIN PARTIAL PEPTIDE AND ANTI-PROSTASIN ANTIBODY 审中-公开
    前列腺素部分肽和抗前列腺素抗体

    公开(公告)号：EP2020417A1

    公开(公告)日：2009-02-04

    申请号：EP07743225.0

    申请日：2007-05-01

    申请人： Hitachi Chemical Company, Ltd. ,  Tomita, Kimio ,  Kitamura, Kenichiro

    发明人： TOMITA, Kimio ,  KITAMURA, Kenichiro ,  IIJIMA, Hiromi ,  OHTA, Noriya

    IPC分类号： C07K7/08 ,  C07K16/40 ,  C12N15/09 ,  G01N21/78 ,  G01N33/574 ,  C12P21/08

    CPC分类号： C07K16/40 ,  C07K16/28 ,  C12N9/6424 ,  G01N33/57484 ,  G01N33/6893 ,  G01N2333/96441 ,  G01N2800/321 ,  Y10S436/811 ,  Y10S436/813

    摘要： An object of the present invention is to provide an antibody that can be stably supplied and can react with prostasin under non-denaturation and denaturation conditions, and an antigen peptide for preparation of the antibody. The present invention relates to a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a peptide consisting of an amino acid sequence that has a deletion, a substitution, or an addition of one or several amino acids with respect to the amino acid sequence shown in SEQ ID NO: 1 and having antigenicity of prostasin. Furthermore, the present invention relates to an antibody prepared using the peptide as an antigen.

    摘要翻译： 本发明的目的在于提供一种抗体，其能够在非变性和变性条件下稳定地供应并且能够与前列腺素反应，并且提供用于制备该抗体的抗原肽。 本发明涉及由序列号1所示的氨基酸序列构成的肽或由相对于该氨基酸序列具有1个或数个氨基酸的缺失，取代或添加的氨基酸序列构成的肽 氨基酸序列如SEQ ID NO：1所示，具有prostasin的抗原性。 此外，本发明涉及使用该肽作为抗原制备的抗体。

    METHOD FOR INDICATING THE PRESENCE OR NON-PRESENCE OF PROSTATE CANCER
    5.
    发明公开
    METHOD FOR INDICATING THE PRESENCE OR NON-PRESENCE OF PROSTATE CANCER 审中-公开
    VERFAHREN ZUR ANZEIGE DES VORHANDENSEINS ODER NICHTVORHANDENSEINS VON PROSTATAKREBS

    公开(公告)号：EP2850432A2

    公开(公告)日：2015-03-25

    申请号：EP13727408.0

    申请日：2013-05-16

    申请人： Phadia AB

    发明人： GRÖNBERG, Henrik ,  EKLUND, Martin

    IPC分类号： G01N33/574 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57434 ,  G01N2333/96441

    摘要： The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to determine if it is likely that the patient suffers from prostate cancer.

    摘要翻译： 本发明一般涉及各种形式的遗传标记物的检测和鉴定，以及各种形式的蛋白质，其具有潜在的用途作为诊断标记。 通过确定患者样品中的多个生物标志物和遗传标记的水平，并且根据预定义的公式组合获得的值，可以确定患者是否可能患有前列腺癌。