公开(公告)号：EP3454891A1

公开(公告)日：2019-03-20

申请号：EP17796763.5

申请日：2017-05-10

申请人： The Regents of The University of Michigan ,  Nanobio Corporation

发明人： BAKER, JR., James R. ,  SMITH, Douglas M. ,  CIOTTI, Susan

IPC分类号： A61K39/00 ,  A61K9/107 ,  A61K39/39

公开(公告)号：EP3442976A1

公开(公告)日：2019-02-20

申请号：EP17717993.4

申请日：2017-04-06

申请人： The Regents of The University of Michigan

发明人： WANG, Shaomeng ,  ZHOU, Bing ,  XU, Fuming ,  HU, Jiantao ,  BAI, Longchuan ,  YANG, Chao-Yie

IPC分类号： C07D487/04 ,  A61K31/4745 ,  A61P35/00

公开(公告)号：EP3442901A1

公开(公告)日：2019-02-20

申请号：EP17783312.6

申请日：2017-04-14

申请人： The Regents of The University of Michigan ,  Wisconsin Alumni Research Foundation

发明人： BEDOLLA PANTOJA, Marco A. ,  ABBOTT, Nicholas L. ,  CHENG, Kenneth ,  LAHANN, Joerg

IPC分类号： B82Y30/00 ,  D01F6/00

公开(公告)号：EP3429585A1

公开(公告)日：2019-01-23

申请号：EP17767444.7

申请日：2017-03-15

申请人： Kura Oncology, Inc. ,  The Regents of The University of Michigan

发明人： WU, Tao ,  LI, Liansheng ,  WANG, Yi ,  REN, Pingda ,  GREMBECKA, Jolanta ,  CIERPICKI, Tomasz ,  KLOSSOWSKI, Szymon ,  POLLOCK, Jonathan ,  BORKIN, Dmitry

IPC分类号： A61K31/445 ,  C07D401/12

公开(公告)号：EP2482716B1

公开(公告)日：2019-01-23

申请号：EP10821337.2

申请日：2010-10-01

申请人： The Regents of The University of Michigan

发明人： HARTE, Steven E. ,  KRUGER, Grant H. ,  CLAUW, Daniel

IPC分类号： A61B5/00 ,  A61B5/22

公开(公告)号：EP3423001A1

公开(公告)日：2019-01-09

申请号：EP17760818.9

申请日：2017-03-02

申请人： The Regents of The University of Michigan

发明人： LARKIN, Lisa, M. ,  ARRUDA, Ellen, M. ,  SMIETANA, Michael ,  BEDI, Asheesh ,  NOVAKOVA, Stoyna

IPC分类号： A61F2/08 ,  A61B17/04 ,  A61B17/06 ,  A61B17/56 ,  A61F2/30 ,  A61K35/12

公开(公告)号：EP3069098B1

公开(公告)日：2019-01-09

申请号：EP14881432.0

申请日：2014-11-14

申请人： The Regents Of The University Of Michigan

发明人： THOULESS, Michael ,  ARRUDA, Ellen M. ,  RAHIMZADEH, Tanaz ,  WAAS, Anthony M.

IPC分类号： F41H1/04

公开(公告)号：EP2475859B1

公开(公告)日：2018-12-05

申请号：EP10816164.7

申请日：2010-09-10

申请人： The Regents of the University of Michigan

发明人： DAHM, Werner, J.A.

IPC分类号： F02K7/10 ,  F02K9/66 ,  F23R3/40 ,  F02C7/22 ,  F02C3/14 ,  F02C3/16 ,  F02C5/04

CPC分类号： F02C7/22 ,  F02C3/14 ,  F02C3/165 ,  F02C5/04 ,  F02K7/10 ,  F02K9/66 ,  F23R3/40

摘要： A method for improving interpenetration, mixing, and combustion between a fuel and oxidizer reactant mixture and combustion product gases in engines having a combustor includes the step of providing an engine having a combustor in which the reaction mixture and product gases are subjected to acceleration directed transverse to a direction along which the reactant mixture flows through the combustor during combustion. One or more catalyst elements are positioned within the combustor to generate Rayleigh-Taylor instability and thereby enhance interpenetration of the reactant mixture and product gases within the combustor chamber during combustion.

公开(公告)号：EP3400073A1

公开(公告)日：2018-11-14

申请号：EP17736443.7

申请日：2017-01-06

申请人： The Regents of The University of Michigan

发明人： SHEA, Lonnie, D. ,  RAO, Shreyas, S. ,  AZARIN, Samira ,  JERUSS, Jacqueline, S. ,  BUSHNELL, Grace

IPC分类号： A61P35/04 ,  A61K31/00 ,  A61K31/74 ,  A61K31/765 ,  A61L31/00 ,  A61L31/16

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/252 ,  C08L67/04 ,  C08L71/02

摘要： The present disclosure relates generally to techniques for capturing cancer cells and, more particularly, to techniques for capturing metastatic cancer cells in vivo.

公开(公告)号：EP3389648A2

公开(公告)日：2018-10-24

申请号：EP16823220.5

申请日：2016-12-16

申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) ,  The Regents of The University of Michigan ,  Iowa State University Research Foundation, Inc.

发明人： ZISCHKA, Hans ,  LICHTMANNEGGER, Josef ,  DISPIRITO, Alan, Angelo ,  SEMRAU, Jeremy, David

IPC分类号： A61K31/30 ,  A61K38/00 ,  A61K31/315 ,  A61K31/4166 ,  A61P1/16

CPC分类号： A61K31/30 ,  A61K31/315 ,  A61K31/4166 ,  A61K38/164

摘要： The present invention relates to the field of (bio-)medicine, and more particularly to the treatment of copper-related diseases. Novel means and methods for depleting (excess) copper from organs and/or the circulation are provided. Agents with a high copper binding affinity and stabilized forms thereof are provided, as well as a novel treatment regimen. The means and methods of the present invention are particularly useful for treatment of Wilson Disease, but also for treatment of other conditions.