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1.发明公开
公开(公告)号：EP3442901A1
公开(公告)日：2019-02-20
申请号：EP17783312.6
申请日：2017-04-14
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公开(公告)号：EP4433037A1
公开(公告)日：2024-09-25
申请号：EP22896533.1
申请日：2022-11-18
CPC分类号： A61K33/16 , A61P1/02 , A61K9/5161
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3.发明公开
公开(公告)号：EP3455348A1
公开(公告)日：2019-03-20
申请号：EP17796855.9
申请日：2017-05-11
发明人： RAMCHARAN, Stacy , SOLORIO, Luis , JORDAHL, Jacob , LAHANN, Joerg
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公开(公告)号：EP3365028A1
公开(公告)日：2018-08-29
申请号：EP16858371.4
申请日：2016-10-21
发明人： LAHANN, Joerg , CHANG, Sywe-Ren , CLARKSON, Brian , JONES, Nathan A. , CZAJKA-JAKUBOWSKA, Agata
CPC分类号： A61K49/0054 , A61K8/0241 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/55 , A61K8/64 , A61K8/72 , A61K8/732 , A61K8/736 , A61K49/0043 , A61K49/0063 , A61K2800/413 , A61K2800/434 , A61K2800/5426 , A61K2800/654 , A61K2800/81 , A61K2800/92 , A61Q11/00
摘要： Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.
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公开(公告)号：EP1809719A2
公开(公告)日：2007-07-25
申请号：EP05858311.3
申请日：2005-11-10
发明人： LAHANN, Joerg , MARTIN, David , ROH, Kyung-ho
CPC分类号： D01D5/0069 , B82Y10/00 , B82Y30/00 , C08J3/12 , C08J3/20 , C08J3/246 , C08J2371/12 , D01D5/32 , D01F8/00 , Y10S977/906
摘要： A method of forming multi-phasic nano-objects involves the jetting of two or more different liquids in side-by-side capillaries thereby generating a composite liquid stream. The composite then exposed to a force field which causes the composite liquid stream to at least partially solidify into a nano-object. The method forms a nano-object having a number of morphologies such as rods, spheres, and fibers.
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公开(公告)号：EP2582288B1
公开(公告)日：2018-02-28
申请号：EP11796450.2
申请日：2011-06-16
发明人： KIPKE, Daryl R. , KOZAI, Takashi Daniel Yoshida , LANGHALS, Nick , LAHANN, Joerg , KOTOV, Nicholas A. , DENG, Xiaopei , PATEL, Paras
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/05 , A61N1/0529 , A61N1/0551 , B82Y5/00
摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.
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公开(公告)号：EP2582288A2
公开(公告)日：2013-04-24
申请号：EP11796450.2
申请日：2011-06-16
发明人： KIPKE, Daryl R. , KOZAI, Takashi Daniel Yoshida , LANGHALS, Nick , LAHANN, Joerg , KOTOV, Nicholas A. , DENG, Xiaopei , PATEL, Paras
IPC分类号： A61B5/0215 , A61B5/0478 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/05 , A61N1/0529 , A61N1/0551 , B82Y5/00
摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.
摘要翻译： 本公开提供了可用于各种医疗装置中的坚固的可植入微型部件电极。 例如，医疗装置可以是可以监控或刺激生物体的脑，脊柱，神经或器官中的神经活动的神经探针。 微元件电极具有小的物理外形，具有超薄尺寸，同时具有高强度和柔性。 微电极具有导电芯材料，例如碳。 核心材料的表面包括涂覆有导电材料的一个或多个导电区域和具有不导电的生物相容性聚合物涂层的一个或多个非导电区域。 具有这种微型部件的可植入装置能够植入生物体很长的时间。
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公开(公告)号：EP1809719B1
公开(公告)日：2013-01-16
申请号：EP05858311.3
申请日：2005-11-10
发明人： LAHANN, Joerg , MARTIN, David , ROH, Kyung-ho
CPC分类号： D01D5/0069 , B82Y10/00 , B82Y30/00 , C08J3/12 , C08J3/20 , C08J3/246 , C08J2371/12 , D01D5/32 , D01F8/00 , Y10S977/906
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公开(公告)号：EP4088744A1
公开(公告)日：2022-11-16
申请号：EP22183087.0
申请日：2016-10-21
发明人： LAHANN, Joerg , CHANG, Sywe-Ren , CLARKSON, Brian , JONES, Nathan A. , CZAJKA-JAKUBOWSKA, Agata
IPC分类号： A61K49/18 , A61P1/02 , A61K8/21 , A61K49/00 , A61K8/24 , A61Q11/00 , A61K8/73 , A61B5/00 , A61K8/02 , A61K47/50
摘要： Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.
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公开(公告)号：EP3596175A1
公开(公告)日：2020-01-22
申请号：EP18767010.4
申请日：2018-03-16
发明人： MALLERY, Susan R. , LAHANN, Joerg
IPC分类号： C09D11/00
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