公开(公告)号：EP2753362A4

公开(公告)日：2015-04-15

申请号：EP12830863

申请日：2012-09-10

申请人： UNIV FLORIDA

发明人： BRUSKO TODD ,  KESELOWSKY BENJAMIN ,  CSERNY JUDIT

IPC分类号： A61K47/48 ,  A61K9/16 ,  A61K9/48 ,  A61K9/51 ,  A61K38/20 ,  A61P3/10 ,  A61P29/00

CPC分类号： A61K31/436 ,  A61K9/5153 ,  A61K31/453 ,  A61K31/4704 ,  A61K38/2013 ,  A61K38/28 ,  A61K38/51 ,  A61K47/48776 ,  A61K47/48915 ,  A61K47/6901 ,  A61K47/6937 ,  C12Y401/01015 ,  A61K2300/00

摘要： The present invention provides nanoparticle-coupled tolerogenic Treg cell therapy for treatment of immune and/or autoimmune disorders. In certain specific embodiments, the present invention can be used in the prevention and/or treatment of autoimmune diseases including, but not limited to, type 1 diabetes, lupus erythematosus (SLE), multiple sclerosis (MS), inflammatory bowel disease (IBD), rheumatoid arthritis, oophoritis, and autoimmune pathology associated with Graft versus Host Disease (GvHD) following hematopoietic stem cell transplantation.

公开(公告)号：EP2670395B1

公开(公告)日：2015-03-25

申请号：EP12705203.3

申请日：2012-02-03

申请人： Novartis AG

发明人： WEERS, Jeffry ,  RAO, Nagaraja ,  TARARA, Thomas E. ,  HUANG, Daniel ,  MILLER, Danforth

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61P11/00 ,  A61K45/06 ,  A61M15/00 ,  A61K9/16 ,  A61K9/50 ,  A61K31/40 ,  A61K31/56 ,  A61K31/58 ,  A61K31/4704

CPC分类号： A61K9/50 ,  A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/501 ,  A61K9/5015 ,  A61K31/40 ,  A61K31/4704 ,  A61K31/56 ,  A61K31/58 ,  A61K45/06 ,  A61M15/00

公开(公告)号：EP2736336A4

公开(公告)日：2015-03-04

申请号：EP12817547

申请日：2012-07-27

申请人： TEVA PHARMA

发明人： GILGUN YOSSI ,  TARCIC NORA

IPC分类号： A61K31/47 ,  A61K31/4704 ,  A61K38/21 ,  A61P25/00

CPC分类号： A61K38/215 ,  A61J1/03 ,  A61J1/14 ,  A61K9/0019 ,  A61K31/47 ,  A61K31/4704 ,  A61K45/06 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K2300/00

公开(公告)号：EP2276740B8

公开(公告)日：2015-02-18

申请号：EP09738481.2

申请日：2009-04-27

申请人： Actavis Group PTC ehf

发明人： DIXIT, Girish ,  SHARMA, Krishnadatt ,  SHEKHAWAT, Kundan, Singh ,  PRADHAN, Nitin, Sharadchandra ,  VALGEIRSSON, Jon

IPC分类号： C07D215/22

CPC分类号： C07D215/56 ,  A61K31/4704 ,  C07D215/22

公开(公告)号：EP2830623A1

公开(公告)日：2015-02-04

申请号：EP13768294.4

申请日：2013-03-26

申请人： Teva Pharmaceutical Industries Ltd.

发明人： KAYE, Joel, Flaxman

IPC分类号： A61K31/4704

CPC分类号： A61K31/4704 ,  A61K31/225 ,  A61K31/47 ,  A61K45/06 ,  A61K2300/00

摘要： This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on therapy to or in combination with DMF. This invention also provides a package comprising laquinimod and DMF for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides laquinimod for use as an add-on therapy or in combination with DMF in treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides a pharmaceutical composition comprising laquinimod and DMF for use in treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention further provides use of laquinimod and DMF in the preparation of a combination for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome.

公开(公告)号：EP2790698A1

公开(公告)日：2014-10-22

申请号：EP12857218.7

申请日：2012-12-13

申请人： IO Therapeutics, Inc. ,  Trustees of Dartmouth College

发明人： CHANDRARATNA, Roshantha, A. ,  DMITROVSKY, Ethan ,  NOWAK, Elizabeth ,  NOELLE, Randolph

IPC分类号： A61K31/435 ,  A61K31/353 ,  A61K31/35 ,  A61K31/34 ,  A61P37/00

CPC分类号： A61K31/192 ,  A61K9/0073 ,  A61K31/201 ,  A61K31/216 ,  A61K31/343 ,  A61K31/353 ,  A61K31/47 ,  A61K31/4704

摘要： The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.

摘要翻译： 本说明书提供RXR激动剂化合物，包含这种RXR激动剂的组合物，以及使用这些化合物和组合物治疗自身免疫性疾病，与自身免疫性疾病相关的炎症和/或移植排斥的方法以及使用这种RXR激动剂来制造 这些化合物和组合物的药物和用途，用于治疗自身免疫性疾病，与自身免疫性疾病相关的炎症和/或移植排斥反应。

公开(公告)号：EP2766020A1

公开(公告)日：2014-08-20

申请号：EP12840715.2

申请日：2012-10-11

申请人： Teva Pharmaceutical Industries Ltd.

发明人： HALLAK, Hussein ,  TARCIC, Nora ,  FLAXMAN KAYE, Joel

IPC分类号： A61K31/47 ,  A61K31/135

CPC分类号： A61K31/47 ,  A61J1/035 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/28 ,  A61K9/48 ,  A61K31/137 ,  A61K31/4704 ,  A61K45/06 ,  A61K47/02 ,  A61K47/26 ,  A61K2300/00

摘要： This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on therapy to or in combination with fingolimod. This invention also provides a package and a pharmaceutical composition comprising laquinimod and fingolimod for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides laquinimod for use as an add-on therapy or in combination with fingolimod in treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention further provides use of laquinimod and fingolimod in the preparation of a combination for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome.

公开(公告)号：EP2749284A3

公开(公告)日：2014-08-20

申请号：EP14162113.6

申请日：2012-02-17

申请人： Cipla Limited

发明人： Malhotra, Geena ,  Purandare, Shrinivas Madhukar

IPC分类号： A61K31/40 ,  A61K31/4704 ,  A61K31/57 ,  A61K31/58 ,  A61P11/06 ,  A61P11/00

CPC分类号： A61K31/40 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/135 ,  A61K31/138 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/538 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58 ,  A61K47/06 ,  A61K47/26 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions for inhalation comprising glycopyrronium and carmoterol; to a process for preparing such compositions and to the use of such compositions for the prevention and/or treatment of respiratory, inflammatory or obstructive airway disease.

摘要翻译： 本发明涉及用于吸入的药物组合物，其包含格隆铵和卡莫特罗; 涉及用于制备这种组合物的方法以及这种组合物用于预防和/或治疗呼吸，炎症或阻塞性气道疾病的用途。

公开(公告)号：EP2566487A4

公开(公告)日：2014-06-18

申请号：EP11778244

申请日：2011-05-04

申请人： SENJU USA INC

发明人： INOUE JUN ,  SHAH TAPAN

IPC分类号： A61K31/74 ,  A61K9/00 ,  A61K31/138 ,  A61K31/382 ,  A61K31/433 ,  A61K31/4704 ,  A61K31/5377 ,  A61K31/542 ,  A61K47/34

CPC分类号： A61K31/382 ,  A61K9/0048 ,  A61K31/138 ,  A61K31/433 ,  A61K31/4704 ,  A61K31/5377 ,  A61K31/542 ,  A61K47/34 ,  A61K2300/00

公开(公告)号：EP2682102A3

公开(公告)日：2014-05-07

申请号：EP13175159.6

申请日：2013-07-04

申请人： Arven Ilac Sanayi Ve Ticaret A.S.

发明人： Cifter, Ümit ,  Türkyilmaz, Ali ,  Mutlu, Onur

IPC分类号： A61K9/14 ,  A61K31/12 ,  A61K31/56

CPC分类号： A61K47/26 ,  A61K9/0075 ,  A61K9/14 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/46 ,  A61K31/4704 ,  A61K31/538 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61M15/0025 ,  A61M15/003 ,  A61M15/0045 ,  A61M2202/064 ,  A61K2300/00

摘要： The invention relates to pharmaceutical powder compositions administered by means of inhalers. More particularly, it relates to pharmaceutical powder compositions having the content uniformity and the desired stability used in inhaler devices.