摘要:
The present invention provides a composition capable of hermetically sealing a PCR reaction vessel without using a closure member or adhesive seal. Disclosed is a composition for preventing evaporation of a nucleic acid amplification reaction solution during nucleic acid amplification reaction, which is a liquid during the reaction and becomes a solid through chemical or thermal changes after completion of the reaction. Also disclosed is a composition for preventing evaporation of a nucleic acid amplification reaction solution during nucleic acid amplification reaction, wherein the melting point of the composition is 0-15°C. Also disclosed is a composition for preventing evaporation of a nucleic acid amplification reaction solution during nucleic acid amplification reaction, wherein the melting point of the composition is 5-10°C.
摘要:
A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
摘要:
A sample preparation device (12) for handling a biological sample, comprising a multicapillary element (14) comprising a plurality of capillary tubes (16), each capillary tube comprising first and second openings and a wall having an inner surface for retaining a stationary phase (18), and a housing of substantially cylindrical or conical configuration (20) that retains the multicapillary element, wherein the housing comprises a pipette tip, pipette, micropipette, or syringe.
摘要:
An apparatus for punching and extracting analytes from a dried biological fluid spot includes a tube and a sorbent bed. The tube includes a proximal tube opening, a distal tube opening, and a distal section. The distal section includes a tube wall having a tapered diameter that reduces down to the distal tube opening. The apparatus may also include a tube extension that includes an extension wall having a tapered diameter that reduces from a proximal extension opening to a distal extension opening. The tube extension is movable between an attached position and a detached position. At the attached position, the tube extension is secured to the tube by frictional contact between the extension wall and the tube at the distal tube opening. At the detached position the tube extension is physically separate from the tube. The sorbent bed is disposed at an axial distance from the distal tube opening and in the tube or the tube extension. The sorbent bed has a composition configured for solid phase extraction.
摘要:
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
摘要:
A stackable pipette tip tray (10) is described. The pipette tip tray (10) includes a deck (14) having first and second opposing longitudinal side edges (28, 30). A plurality of shaft apertures (24) is arranged into a plurality of longitudinal rows on the deck (14). Each of the shaft apertures (24) has a first size or shape configured to receive a shaft (20) of a pipette tip (22). The deck (14) also includes a plurality of tip apertures (34) that is also arranged into a plurality of longitudinal rows such that at least one of the longitudinal rows of tip apertures (34) is located between an adjacent pair of longitudinal rows of shaft apertures (24). Each of the plurality of tip apertures (34) has a second size or shape, different from the first size or shape, and is configured to receive a distal tip end (32) of a pipette tip (22) when one tray of pipette tips (22) is stacked above another tray of pipette tips (22). The plurality of longitudinal rows of shaft apertures (24) is further arranged such that an outer one of the plurality of longitudinal rows of shaft apertures (24) adjacent the first side edge (28) of the deck (14) is positioned closer to the first side edge (28) than an outer one of the plurality of longitudinal rows of shaft apertures (24) adjacent the second side edge (30) of the deck (14) is positioned relative to the second side edge (30).
摘要:
Die vorliegende Erfindung betrifft eine Pipettierspitze (10) zur Aspiration und Dispensation von Pipettierfluid, welche sich längs einer Pipettierspitzenlängsachse (L) erstreckt, wobei ein erster axialer Längsendbereich (16) der Pipettierspitze (10) als Pipettier-Längsendbereich (16) eine betriebsmäßig von Pipettierfluid durchströmbare Pipettieröffnung (12) aufweist und wobei ein dem Pipettier-Längsendbereich (16) in axialer Richtung entgegengesetzter zweiter axialer Längsendbereich (18) der Pipettierspitze (10) als Kopplungs-Längsendbereich (18) eine Kopplungsgeometrie zur, vorzugsweise lösbaren, Ankopplung an eine Kopplungsgegengeometrie einer Pipettiervorrichtung aufweist, wobei die Pipettierspitze (10) auf ihrer Außenseite (30) einen Außen-Hydrophobiebereich (32) sowie auf ihrer Innenseite (28) einen Innen-Hydrophobiebereich (26) jeweils mit einer quadratischen Rauheit in einem Bereich von 100 nm bis 1000 nm, bevorzugt von 150 nm bis 750 nm und besonders bevorzugt von 200 nm bis 500 nm, und mit einer Peak-to-Peak-Rauheit in einem Bereich von 800 nm bis 5500 nm, bevorzugt von 1750 nm bis 4500 nm und besonders bevorzugt von 2500 nm bis 3700 nm aufweist, wobei sich der axiale Erstreckungsbereich des Außen-Hydrophobiebereichs (32) und der axiale Erstreckungsbereich des Innen-Hydrophobiebereichs (26) voneinander unterscheiden.