公开(公告)号：EP0034304A3

公开(公告)日：1982-03-31

申请号：EP81100791

申请日：1981-02-05

申请人： SORIN BIOMEDICA S.p.A.

发明人： Callegaro, Lanfranco ,  Boniolo, Antonio ,  Denti, Ennio ,  Rosa, Umberto ,  Rossi, Valdano

IPC分类号： C12N11/12 ,  A61M01/03 ,  B01D13/00

CPC分类号： B01D67/0093 ,  A61M1/3679 ,  B01D69/141 ,  C12N11/12 ,  F16L27/04

摘要： The object of the method is to immobilize a desired enzyme on the lumen surfaces of the dialyzer fibres typically having an inner diameter of 200-300 microns and wall thickness of 10-20 microns, without prejudice to the chemico-physical, dialyzing and bio-compatibility properties of the fibres. The enzyme is anchored directly or indirectly through covalent bonds upon activation of the lumen surfaces by circulation through the lumens of an aqueous solution of sodium periodate at a concentration of 0.7 - 21 mg/mi, at a circulation rate of 300-500 mm 3 /minute referred to 1 mm 2 of cross-sectional area of the lumen, at 15-30°C for a time not exceeding 70 minutes.

公开(公告)号：EP0045515A3

公开(公告)日：1982-02-17

申请号：EP81106106

申请日：1981-08-04

申请人： Kuraray Co., Ltd.

发明人： Sato, Takashi ,  Mukai, Makoto ,  Nagata, Shiro ,  Harada, Yoshimichi ,  Kirita, Yasuzo

IPC分类号： A61M01/00 ,  A61M01/03 ,  B01D31/00

CPC分类号： A61M1/34 ,  A61M1/3603 ,  A61M2202/0401 ,  A61M2202/0492 ,  B01D61/145 ,  B01D61/147 ,  B01D61/18 ,  B01D63/02 ,  B01D2313/28 ,  Y10S128/03 ,  A61M2230/005

摘要： An apparatus for treating body cavity fluids such as ascitic fluid and pleural fluid comprises a concentrator for increasing the concentration of proteins in cavity fluids, a filter for filtering the concentrated cavity fluids and thereby removing bacteria or cells contained therein and a pump. The apparatus is characterized in that it is simpler in construction and easier in operation as compared with conventional apparatus.

公开(公告)号：EP0006030A3

公开(公告)日：1980-01-02

申请号：EP79301052

申请日：1979-06-04

申请人： MONSANTO COMPANY

发明人： Carden, Joseph Albert ,  McKinney, J., Ray

IPC分类号： B01D13/04 ,  A61M01/03 ,  C08G69/44

摘要： Permselective membranes are provided consisting of lactam-polyol-polyacyl lactam block terpolymers having from 35 to 75% by weight polylactam blocks and 25 to 65% by weight polyalkylene ether blocks. The membranes are particularly suitable as blood dialysis membranes having improved permeability to solutes in the medium range of molecular weights while maintaining acceptable ultrafiltration rates and permeability to low molecular weight solutes. The membranes are provided both as planar films and hollow fibers, have high hydrolytic stability under hot wet sterilization conditions and good mechanical properties under hemodialysis conditions.

公开(公告)号：EP0003914A3

公开(公告)日：1979-09-19

申请号：EP79300293

申请日：1979-02-26

申请人： PURDUE RESEARCH FOUNDATION

发明人： Ash, Stephen Richard

IPC分类号： A61M01/03 ,  B01D13/00 ,  B01D15/00

CPC分类号： B01D61/30 ,  A61M1/1696 ,  B01D2311/06 ,  B01D2311/2626

摘要： A dialysis composition for adsorption of uremic substances in an artificial kidney is described, comprising a cation exchanger suspended in a suspending agent, A more particular example of such a composition comprises a surface adsorptive agent capable of adsorption of uremic substances; an enzyme to serve as a catalyst for urea degradation; a suspending agent; and a cation exchanger capable of being suspended in said suspending agent. A method for removing uremic substances from blood during hemodialysis with the above dialysis compositions is also described.

公开(公告)号：EP0079221A3

公开(公告)日：1986-01-22

申请号：EP82305913

申请日：1982-11-05

申请人： Baylor College of Medicine

发明人： Terman, David Stephen

IPC分类号： A61K39/385 ,  A61K39/395 ,  C12N11/12 ,  C12N11/04 ,  G01N33/54 ,  A61M01/03

CPC分类号： A61M1/3472 ,  A61M1/3486

摘要： Significantly increased removal of immunal complexes and tumor specific antibody generation are achieved by extracorporeal plasma perfusion over a therapeutic immobilized protein A (staphylococcal). SPA. The perfused plasma is returned to the host or can be taken off one person and used to treat another and stored in perfused plasma banks. Immobilized protein A quantities, volumes of plasma perfused and the rate of administration based on clinical and toxicity evaluations are set forth. A non-toxic drug infusion, such as cytosine arabinoside, during the immediate postperfusion period obtains an observed tumoricidal response far exceeding those due to the extracorporeal plasma perfusion or drug infusion alone representing an in vivo synergism between tumor specific antibody and the drug. Also disclosed are the therapeutic protein A cartridge, its loading and delivery system, a miniaturized immunoabsorbent apparatus enabling the processing of serum samples for testing small quanitities of plasma, and a radioimmuno-assay for detecting and measuring tumor specific antibodies in the serum samples for profiling and screening of patients for treatment and assessment. The United States government has rights in these inventions pursuant to U.S. Public Health Service Grants or Awards 5K04A100302 and 5R01GM23517.

摘要翻译： 通过在治疗性固定化蛋白A（葡萄球菌），SPA上的体外血浆灌注实现显着增加的免疫复合物的去除和肿瘤特异性抗体产生。 将灌注的血浆返回主体，或者将其从一个人中取出并用于治疗另一个并存储在灌注的血浆库中。 固定化蛋白质A量，血浆灌注体积和基于临床和毒性评估的给药速率。 在直接灌注后期间，无毒药物输注如阿糖胞苷获得了远远超过体外等离子体灌注或药物输注的观察到的杀肿瘤反应，代表肿瘤特异性抗体与药物之间的体内协同作用。 还公开了治疗性蛋白A盒，其装载和递送系统，能够处理血清样品以测试血浆的小量的微型免疫吸收装置，以及用于检测和测量血清样品中的肿瘤特异性抗体的放射免疫分析 并筛查患者的治疗和评估。 美国政府根据美国公共卫生服务补助金或奖励5K04AI00302和5R01GM23517对这些发明有权利。

公开(公告)号：EP0128683A3

公开(公告)日：1986-01-15

申请号：EP84303509

申请日：1984-05-24

申请人： BAXTER TRAVENOL LABORATORIES, INC.

发明人： Bilstad, Arnold C. ,  Brown, Richard I. ,  Kruger, Robert J.

IPC分类号： A61M01/03

CPC分类号： A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M5/16845 ,  A61M2205/3382 ,  A61M2205/3386

摘要： A single needle batch-type blood fractionation system for separating plasma from whole blood includes a disposable flow system having a single-lumen phlebotomy needle and associated donor conduit, a flow-through plasma separation filter, and an in-process fluid reservoir. During an initial draw cycle whole blood is pumped through the filter to the in-process reservoir by a peristaltic-type inlet pump operating at a predetermined draw rate. When a predetermined volume of filtered plasma-deficient blood has been collected in the reservoir, as sensed by the weight of the reservoir the system reverts to a return cycle wherein a portion of the plasma deficient blood in the reservoir is pumped back to the donor conduit by a peristaltic-type return pump operating at a predetermined return rate higher than the draw rate of the inlet pump. Depending on the relative operating speeds of the inlet and return pumps, an operator-controlfable portion of the plasma-deficient blood from the in-process reservoir is returned to the donor through the phlebotomy needle, and the remaining portion is recirculated through the filter. The partial recirculation of plasma-deficient blood through the filter during the return mode reduces the processing time of the system, provides for improved accommodation of whole blood of unusually high or low hematocrit, and enables the use of a smaller and less expensive filter.

公开(公告)号：EP0111696A3

公开(公告)日：1984-07-25

申请号：EP83110796

申请日：1983-10-28

申请人： Gambro Lundia AB

发明人： Larsson, Lars-Ake Lennart ,  Nilsson, Ake Wallys ,  Johansson, Bo Ingemar Willy ,  Nauclér, Lars Olof Vilhelm

IPC分类号： A61M01/03

CPC分类号： A61M1/3679 ,  A61M1/3472 ,  A61M1/3486 ,  A61M2205/707 ,  A61M2205/7554 ,  A61M2205/7581

摘要： An arrangement forthe removal of one or more fractions out of whole blood, plasma or other similar body fluids with the help of adsorption on an adsorption column (23,24) comprising means for the feed of the said fluid of the column and means for the removal of the same. In accordance with the invention the said means for the removal of the fluid comprise at least one analysing device (31,32) for the coarse analysis of the fluid and a valve device (33,34) which is adapted so as to conduct the fluid flow from the column (23,24) as a function of the analysis carried out either to a second analysing device (38,46,47) for the fine analysis of the fluid or back to the source (1) of the same, e.g. a patient, or to a drain (36). The arrangement can be eluated with the help of a regenerating liquid which is adapted so as to tower the pH of the column gradually during a certain period. Preferably means are adapted so that at the start of the period a rapid loweing is achieved so as to accelerate the starting of the regeneration, whereupon the lowering is adapted so as to occur slowly during the actual regeneration, and appropriately to be terminated rapidly during the finish of the said period.

公开(公告)号：EP0106940A3

公开(公告)日：1984-07-18

申请号：EP83106547

申请日：1983-07-05

申请人： Gambro Lundia AB

发明人： Gummesson, Bengt-Ake Göran ,  Holmberg, Bengt Magnus ,  Jönsson, Sven Anders ,  Mattisson, Ulf Kenneth

IPC分类号： G01F01/58 ,  A61M01/03

CPC分类号： A61M1/16 ,  F02P5/152 ,  G01F1/58 ,  G01L23/225 ,  Y02T10/46

摘要： An arrangement for the measurement of the difference between two flows in two separate ducts with the help of one or more monitoring electrodes or the like arranged in respective ducts. The flow in the one duct is adapted so that it is capable of being transferred to the other duct. This can be done, for example, with the help of means for the alternate change-over of the flows from the respective ducts to the opposite duct, so that ultimately all the electrodes and/ or duct walls are acted upon to a substantially equal extent. Alternatively this may be achieved with the help of means for conducting one and the same flow through both ducts when the flow difference becomes zero and the measured value can be used as a new zero value for the continued measurement.

公开(公告)号：EP0097863A3

公开(公告)日：1984-04-18

申请号：EP83105769

申请日：1983-06-13

申请人： Gambro Lundia AB

发明人： Shaldon, Stanley ,  Beau, Marie Claude

IPC分类号： A61M01/03 ,  A61M05/00 ,  B01D13/00 ,  A61L02/02

CPC分类号： B01D61/142 ,  A61L2/022 ,  A61M1/1656 ,  A61M1/1672 ,  A61M1/1676 ,  B01D69/081 ,  B01F5/06 ,  B01F13/00

摘要： Methods for mixing fluids in a filter member including a filtration membrane are disclosed. The methods include supplying a first fluid through an inlet to one side of the filtration membrane, supplying a second fluid through a second inlet to that same side of the filtration membrane, and withdrawing the mixture of those fluids from the other or filtrate side of the filtration membrane through a fluid outlet. The method has particular application in the medical field, such as in connection with the mixing of blood components and related fluids.

公开(公告)号：EP0098392A3

公开(公告)日：1984-03-07

申请号：EP83105534

申请日：1983-06-06

申请人： GAMBRO DIALYSATOREN K.G. ,  Gambro Lundia AB

发明人： Göhl, Hermann Joseph ,  Geiling, Günther Friedrich ,  Mayer, Georg Bernhard ,  Gullberg, Claes-Ake

IPC分类号： B01D13/04 ,  A61M01/03

CPC分类号： D01D5/24 ,  B01D69/02 ,  B01D69/08 ,  B01D71/56

摘要： Filtration membrane, especially adapted for use in hemofiltration as well as filtration of infusion solutions. The membrane, preferably in the form of a hollow fiber, is made of a polymer which is soluble in a polar, non-protonic organic solvent. The most preferred polymer for the membrane material is polyamide. Characterizing for the membrane is high ultrafiltration rates (permeabilities to water) of up to 500 x 10- 4 ml/sec. x cm2 x atm., and impermeability to albumin (M w 68,000). The membrane is prepared by extruding a polymer solution with a center liquid under conditions such that the volume of polymer solution to volume of center liquid ratio is within the range of from 2 : 1 to 4 : 1. Simultaneously, the inner diameter to wall thickness ratio of the hollow fiber is preferably correlated to the polymer concentration and is set to 150:75 to 280:75 at a polymer concentration of 5-20%. The most preferred such correlation is 220 : 75 at a polymer concentration of 11 %.