摘要:
Method of spray-drying a high-viscosity fluid, e.g. comprising a food product. The method comprises providing a nozzle plate wherein at least one nozzle is provided, said nozzle plate having an inner main surface and an outer main surface. The method comprises providing the high-viscosity fluid in a reservoir that is in fluidum connection with the at least one nozzle. The method comprises pressurizing the high-viscosity fluid in the reservoir, wherein the fluid flows, as a result of said pressurizing, towards the nozzle plate, thus creating a pressure difference over the at least one nozzle so that the fluid flows out of the at least one nozzle, thereby passing the outer main surface after passing the inner main surface. A cross-sectional area of the at least one nozzle in the inner main surface exceeds a cross-sectional area of the at least one nozzle in the outer main surface.
摘要:
Die vorliegende Erfindung betrifft Vorrichtungen und Verfahren zur Schmelzekonfektionierung mittels laminaren Strahlzerfalls. Insbesondere betrifft die vorliegende Erfindung Vorrichtungen zur Herstellung von Partikeln aus Schmelzen innerhalb eines Gasraumes, umfassend mindestens einen Schmelzeverteilerkörper mit mindestens einer Schmelzezuführung, mindestens einem Schmelzekanal und einer Verteilerplatte mit einem oder mehreren Löchern. Die vorliegende Erfindung betrifft ferner Verfahren zur Herstellung von Partikeln aus Schmelzen innerhalb eines Gasraumes unter Einsatz der erfindungsgemäßen Vorrichtungen.
摘要:
A particulate material production apparatus (1) is disclosed. The particulate material production apparatus (1) includes a droplet ejector (2; 105) to eject droplets of a particulate material composition liquid or a melted particulate material composition in a droplet ejection direction from nozzles (19); a solidifying device (60) to solidify the droplets; a first airflow forming device (7) to form a first airflow to feed the ejected droplets to the solidifying device (60) with the first airflow; and a second airflow forming device (108; 108-2, 106;108-3, 106; 108-4) to form a second airflow to apply the second airflow the droplets before the droplets are fed by the first airflow. The second airflow forming device (108; 108-2, 106;108-3, 106; 108-4) forms the second airflow by supplying a pressed gas from a slit (103), and the traveling direction of the first airflow is substantially perpendicular to the droplet ejection direction.
摘要:
An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
摘要:
Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents. A formulation may also include a suspension of micron or submicron sized particles dispersed within a solvent. Or, a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent (e.g., liposome/micelle containing a pharmaceutical, polynucleotide, etc.). In some cases, the polydispersity index of the particle size distribution in a formulation is less than 0.1. Formulations may be suitably prepared using focused acoustic energy that results in a reduction of the average particle size of a mixture. Alternatively, suitable formulations may be prepared using focused acoustics in a manner that does not reduce the average particle size of the mixture.
摘要:
The present invention relates to a method for the production of micro-particles of polysaccharides. The method includes preparing a feeding solution and a gelifying liquid to collect nebulized jets of the feeding solution. The feeding solution contains at least one polymer capable of forming micro-particle structures and at least one biologically active substance. The feeding solution is pressurized inside an air-less nebulizing unit and then nebulized through the unit itself so as to generate nebulized jets impacting the surface of the gelifying liquid.
摘要:
The spray head (104) of the apparatus comprises a motor (16) of which the vertical hollow shaft (12) is secured, at its lower end, to a centrifugal ejection disc (11). The substance to be sprayed, coming from a tank (106) via a metering pump (107), passes through the hollow shaft (12) to expand as a layer on the lower surface of the disc forming a centrifugal ejection face. Means are provided to vibrate the peripheral edge of the disc and thus control the spraying of the substance, in particular its particle size. A fan (124) and a distributor (109) form a gaseous treatment flow (111) which meets the droplets and entrains them to a collection zone (112), thereby solidifying them by drying or coagulation. Typically, the substance is a mixture of at least one active ingredient and a microencapsulation component. Use in particular for obtaining very fine and/or very homogeneous particle sizes, for manufacturing powders intended for agro-food, nutritional, cosmetic, pharmaceutical and fine chemistry applications. The head can be used separately for producing aerosols.
摘要:
A system for making agglomerates from material like wet chopped glass fiber strand segments is disclosed. Agglomerates, made by feeding wet chopped fiber strand segments into a wave chamber having a vibrating curved surface supporting a curved, dimpled liner working surface have improved density and flow characteristics compared with dry chopped strands, but it was discovered that the dimpled liner flexes during operation during vibration causing undesirable variation in properties like agglomerate size. In the invention the dimpled liner is backed up with a substantially non-compressible material and this results in agglomerates that have even better uniformity of flow and agglomerate diameters. Typical backing materials include a particulate material, an elastomer, a rigidized elastomer, slurry or liquid, or wire or slivers of metal.