公开(公告)号：EP2588222A2

公开(公告)日：2013-05-08

申请号：EP11738844.7

申请日：2011-07-01

申请人： Covaris, Inc.

发明人： BECKETT, Carl ,  LAUGHARN, James, A, Jr. ,  KAKUMANU, Srikanth

IPC分类号： B01F11/02 ,  B01J2/18 ,  B01J19/10

CPC分类号： B01F11/0283 ,  B01F3/0807 ,  B01F2215/0431 ,  B01F2215/0454 ,  B01F2215/0477 ,  B01J2/18 ,  B01J2219/00932

摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents. A formulation may also include a suspension of micron or submicron sized particles dispersed within a solvent. Or, a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent (e.g., liposome/micelle containing a pharmaceutical, polynucleotide, etc.). In some cases, the polydispersity index of the particle size distribution in a formulation is less than 0.1. Formulations may be suitably prepared using focused acoustic energy that results in a reduction of the average particle size of a mixture. Alternatively, suitable formulations may be prepared using focused acoustics in a manner that does not reduce the average particle size of the mixture.

公开(公告)号：EP2588222B1

公开(公告)日：2016-09-07

申请号：EP11738844.7

申请日：2011-07-01

申请人： Covaris, Inc.

发明人： BECKETT, Carl ,  LAUGHARN, James, A, Jr. ,  KAKUMANU, Srikanth

IPC分类号： B01F3/08 ,  B01F11/02 ,  B01J2/18 ,  B01J19/10

CPC分类号： B01F11/0283 ,  B01F3/0807 ,  B01F2215/0431 ,  B01F2215/0454 ,  B01F2215/0477 ,  B01J2/18 ,  B01J2219/00932