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41.发明公开Process for preparing ibuprofen and its alkyl esters 失效维他命Zur Herstellung von Ibuprofen und dessen烷基酯。
公开(公告)号：EP0434343A1
公开(公告)日：1991-06-26
申请号：EP90313782.6
申请日：1990-12-17
Applicant: ALBEMARLE CORPORATION
IPC: C07C51/10 , C07C57/30 , C07C67/36 , C07C69/612
Abstract: A new process for preparing ibuprofen or its alkyl esters is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted with carbon monoxide in the presence of water or an alcohol at a temperature between 10°C and 200°C. An excess of several moles of water or alcohol is preferred. An acid such as hydrochloric acid may also be added. As catalyst, a palladium compound and at least one acid-stable ligand are present; and an excess of ligand over palladium is advantageous.
Abstract translation: 提供了一种制备布洛芬或其烷基酯的新方法。 1-卤代-1-（4-异丁基苯基）乙烷在水或醇的存在下，在10℃至200℃的温度下与一氧化碳反应。优选过量的几摩尔水或醇。 还可以加入酸如盐酸。 作为催化剂，存在钯化合物和至少一种酸稳定配体; 并且过量的配体在钯上是有利的。
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公开(公告)号：EP0341961A2
公开(公告)日：1989-11-15
申请号：EP89304645.8
申请日：1989-05-08
Applicant: Merck & Co., Inc.
Inventor： Thompson, Wayne J. , Thompson, David D. , Anderson, Paul S. , Rodan, Gideon A.
IPC: C07C121/50 , C07C101/20 , C07C103/84 , C07C101/447 , C07C79/38 , C07C69/612 , C07C69/767 , C07J1/00 , C07D333/34 , A61K31/215 , A61K31/275
CPC classification number: C07J41/0072 , C07C205/44 , C07C205/56 , C07C229/34 , C07C233/87 , C07C255/57 , C07C271/34 , C07D333/34 , C07J51/00
Abstract: The invention relates to novel polymalonic acids which act as bone-affinity agents. Compounds of the formula
have a high affinity for bone and are useful in the treatment and prevention of diseases involving bone resorption, particularly osteoporosis, Paget's disease, and malignant hypercalcemia, by delivering a bone resorption or formation active-drug directly to the bone target site.Abstract translation: 本发明涉及作为骨亲和剂的新型聚丙二酸。 式
的化合物对骨具有高亲和力，可用于治疗和预防涉及骨吸收的疾病，特别是骨质疏松症，佩吉特氏病和恶性高钙血症，通过将骨吸收或形成活性药物直接递送至 骨靶点。 -
43.发明公开Diethylenglykolmonoester, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel 失效Diethylenglykolmonoester，Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel。
公开(公告)号：EP0336147A2
公开(公告)日：1989-10-11
申请号：EP89104496.8
申请日：1989-03-14
Applicant: Merckle GmbH
Inventor： Metz, Gunter, Dr. , Räuchle, Kurt, Dr. , Erdmann, Manfred
IPC: C07D231/12 , C07C101/453 , C07C69/738 , C07C69/612 , C07C69/65 , C07C67/08 , A61K31/415 , A61K31/25
CPC classification number: C07D231/12 , C07C229/42
Abstract: Diethylenglykolmonoester von antirheumatisch wirksamen Säuren wie z.B. Lonazolac und Diclofenac u.ä. sind neue Verbindungen und besitzen gegenüber den Säure-Grundkörpern bessere entzündungshemmende Eigenschaften. Sie können durch direkte Veresterung ohne Wasserauskreisung hergestellt werden und sind zur Bekämpfung von Krankheiten des rheumatischen Formenkreises geeignet.
Abstract translation: 抗风湿酸的二甘醇单酯，例如，咪唑烷和双氯芬酸等是新型化合物，与碱性酸结构相比具有更好的抗炎特性。 它们可以通过直接酯化而不从循环中除去水来制备，并且适用于控制风湿型疾病。
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公开(公告)号：EP0271240A3
公开(公告)日：1989-10-11
申请号：EP87310219.8
申请日：1987-11-17
Applicant: ZENECA LIMITED
Inventor： Robson, Michael John
IPC: C07C69/74 , C07C69/743 , C07C69/747 , C07C69/65 , C07C69/612 , C07C33/48 , A01N53/00
CPC classification number: A01N53/00 , C07C33/483
Abstract: The invention provides novel insecticidally and acaricidally active compounds of formula (I) :
wherein X represents the residue of any carboxylic acid X-COOH which forms an insecticidally active ester with a 3-phenoxybenzyl alcohol, and R, R⁶ and R⁷ are each selected from hydrogen, halogen, and alkyl of up to four carbon atoms, provided that at least one of R, R⁶ and R⁷ represents halogen, and further provided that R and R⁶ are not both bromine when R⁷ is hydrogen. The invention also provides processes for the preparation of compounds of formula (I), compositions comprising them, and methods of combating insect and acarine pests therewith. The invention provides intermediates for the preparation of the compounds of formula (I), those intermediates having the formula :
and processes for their preparation.-
公开(公告)号：EP0271240A2
公开(公告)日：1988-06-15
申请号：EP87310219.8
申请日：1987-11-17
Applicant: ZENECA LIMITED
Inventor： Robson, Michael John
IPC: C07C69/74 , C07C69/743 , C07C69/747 , C07C69/65 , C07C69/612 , C07C33/48 , A01N53/00
CPC classification number: A01N53/00 , C07C33/483
Abstract: The invention provides novel insecticidally and acaricidally active compounds of formula (I) :
wherein X represents the residue of any carboxylic acid X-COOH which forms an insecticidally active ester with a 3-phenoxybenzyl alcohol, and R, R⁶ and R⁷ are each selected from hydrogen, halogen, and alkyl of up to four carbon atoms, provided that at least one of R, R⁶ and R⁷ represents halogen, and further provided that R and R⁶ are not both bromine when R⁷ is hydrogen. The invention also provides processes for the preparation of compounds of formula (I), compositions comprising them, and methods of combating insect and acarine pests therewith. The invention provides intermediates for the preparation of the compounds of formula (I), those intermediates having the formula :
and processes for their preparation.Abstract translation: 本发明提供新的杀虫杀螨活性的式（I）化合物：其中X代表与3-苯氧基苄醇形成杀虫活性酯的任何羧酸X-COOH的残基，R，R 6， R 7和R 7各自选自氢，卤素和至多4个碳原子的烷基，条件是R，R 6和R 7中的至少一个表示卤素，并且进一步地，R和R' 6>当R 7是氢时不同时为溴。 本发明还提供了制备式（I）化合物，包含它们的组合物和与其相抗的昆虫和螨类害虫的方法。 本发明提供制备式（I）化合物，具有下式的那些中间体的中间体：＆lt; CHEM＆gt;及其制备方法。 Ť
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Patent Agency Ranking46.发明授权
公开(公告)号：EP0143381B1
公开(公告)日：1988-03-09
申请号：EP84113576.7
申请日：1984-11-10
Applicant: Dr. L. ZAMBELETTI S.p.A.
IPC: C07C69/612 , C07C69/616 , C07C67/26
CPC classification number: C07C69/616
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47.发明公开
公开(公告)号：EP0189129A3
公开(公告)日：1987-09-23
申请号：EP86100541
申请日：1986-01-17
Applicant: BASF Aktiengesellschaft
Inventor： Menig, Helmuth, Dr. , Halbritter, Klaus, Dr.
IPC: C07C69/34 , C07C31/125 , C07D307/20 , C07C33/025 , C07C69/612 , C07C69/708 , C07C69/80 , C07D307/32 , C07D307/60
CPC classification number: C07D307/33 , C07C29/44 , C07C51/567 , C07D307/20 , C07C33/025 , C07C31/125
Abstract: Addition von H und einem Rest I′ (R¹ = org. C-Rest; R² = H, R¹; R³ = C₁-C₄-Alkyl) an olefinisch oder acetylenisch ungesättigte Verbindungen II (Y = H oder zusammen eine weitere Bindung; n = 0 oder 1; A, B = -CO-O-; -O-CO-; -CRR-O-; -CR-NR-; R = H, C₁-C₄-Alkyl, gleich oder verschieden; R⁴, R⁵ = H, org. Rest; A + B (n = 1) bzw. A + B (n = 0) können zu 5- oder 6-Ring verbunden sein) unter Bildung von IIIa und IIIb in dem man Aldehyde I
Abstract translation: （R 1 =有机碳基团; R 2 = H，R 1; R 3 = C 1 -C 4烷基）加成到烯属或炔属不饱和基团上 （Y = H或一起为另一个键; n = 0或1; A，B = -CO-O-; -O-CO-; -CRR-O-; -CR-NR-; R = H，C 1 -C 4 - 烷基，相同或不同; R 4，R 5 = H，有机基团; A + B（n = 1）或A + B（n = 得到5-或6-元环）与IIIa和IIIb的形成通过使醛I与有机自由基形成剂反应。
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公开(公告)号：EP0139252A3
公开(公告)日：1987-06-24
申请号：EP84111517
申请日：1984-09-27
Applicant: HOECHST AKTIENGESELLSCHAFT
Inventor： Nestler, Hans Jürgen, Dr.
IPC: C07C67/03 , C07C67/08 , C07C69/614 , C07C69/612 , C07C69/78
CPC classification number: C07C67/08 , C07C69/732 , C07C69/84
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49.发明公开Enzymatische Herstellung optischer Isomere von 2-Halopropionsäuren. 失效Enzymatische Herstellung optischer Isomere von 2-Halopropionsäuren。
公开(公告)号：EP0206436A2
公开(公告)日：1986-12-30
申请号：EP86201209
申请日：1986-02-26
Applicant: MASSACHUSETTS INST TECHNOLOGY
Inventor： KLIBANOV ALEXANDER M , KIRCHNER GEROLD
IPC: C07B55/00 , C07B57/00 , C07C53/122 , C07C53/15 , C07C53/19 , C07C69/612 , C12P7/62 , C12P41/00 , C12P7/40
CPC classification number: C12P41/005 , C12P7/62
Abstract: A method of resolving racemic 2-halopropionic acids by lipase-catalyzed asymmetric esterification in an organic medium is disclosed.
Abstract translation: 公开了通过在有机介质中通过脂肪酶催化的不对称酯化来拆分外消旋2-卤代丙酸的方法。
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公开(公告)号：EP0202737A2
公开(公告)日：1986-11-26
申请号：EP86301891.7
申请日：1986-03-14
Applicant: Tamura, Yasumitsu
Inventor： Tamura, Yasumitsu , Haruta, Junichi
IPC: C07C67/42 , C07C69/612 , C07C69/734 , C07C69/65 , C07C149/40
CPC classification number: C07C323/00
Abstract: Alpha-arylalkanoic esters are prepared by reacting a trivalent iodine compound represented by the general formula:
wherein Ar is an aromatic hydrocarbon group, with a carbonyl compound represented by the general formula
wherein Ar' is an aromatic hydrocarbon, R is a hydrogen atom or an alkyl group and R 1 is a hydrogen atom or an alkyl group, in the presence of an orthocarboxylic ester.Abstract translation: α-芳基链烷酸酯通过如下制备：使由以下通式表示的三价碘化合物：其中Ar是芳族烃基与由以下通式表示的羰基化合物反应其中Ar'是芳族烃，R是氢原子或 烷基，并且R 1是氢原子或烷基，在邻羧酸酯的存在下。
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